| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 7535 |
Name | ZAP70 |
Synonymous | SRK|STD|TZK|ZAP-70;zeta-chain (TCR) associated protein kinase 70kDa;ZAP70;zeta-chain (TCR) associated protein kinase 70kDa |
Definition | 70 kDa zeta-associated protein|70 kDa zeta-chain associated protein|syk-related tyrosine kinase|tyrosine-protein kinase ZAP-70|zeta-chain associated protein kinase, 70kD |
Position | 2q12 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | beta3-integrin(h) + ZAP-70(h) <==> beta3-integrin(h):ZAP-70(h) (binding) | ZAP-70(h) + HIP-55(h) <==> ZAP-70(h):HIP-55(h) (binding) | ZAP-70(h) + ATP --> ZAP-70(h){pY} + ADP (phosphorylation) | ZAP-70(h) --> Syk(h) (binding) | ZAP-70(h) --> LAT(h) (binding) | ZAP-70(h) --> SLP-76(h) (binding) | ZAP-70(h) --> PLCgamma1(h) (binding) | ZAP-70(h) --> Shb(h) (binding) | ZAP-70(h) + ATP --> ZAP-70(h){pY493} + ADP (phosphorylation) | G-alpha-q(h) + ZAP-70(h) + Lck(h) + p110gamma(h) <==> G-alpha-q(h):ZAP-70(h):Lck(h):p110gamma(h) (binding) | ZAP-70(h) + cxcr4(m.s.) <==> ZAP-70(h):cxcr4(m.s.) (binding) | ezrin(h) + ZAP-70(h) <==> ezrin(h):ZAP-70(h) (binding) | ZAP-70(h) + ezrin(h){pT567} <==> ZAP-70(h):ezrin(h){pT567} (binding) | ZAP-70(h) + 2 ATP --> ZAP-70(h){pY319}{pY493} + 2 ADP (phosphorylation) | IFNAR1(h) + ZAP-70(h) + Lck(h) + CD45(h) <==> IFNAR1(h):ZAP-70(h):Lck(h):CD45(h) (binding) | IFNAR1(h) + ZAP-70(h) <==> IFNAR1(h):ZAP-70(h) (binding) | ZAP-70(h) --> IFNgamma(h) (increase of secretion) | ZAP-70(h) --> TNF-alpha(h) (increase of secretion) | ZAP-70(h) + PEP(h) <==> ZAP-70(h):PEP(h) (binding) | ZAP-70(h) + SLP-76(h) <==> ZAP-70(h):SLP-76(h) (binding) | ZAP-70(h) + ATP --> ZAP-70(h){pY319} + ADP (phosphorylation) | ZAP-70(h) + CD3zeta(h){pY} <==> ZAP-70(h):CD3zeta(h){pY} (binding) | ZAP-70(h) + CD3zeta-isoform1(h){pY}2 <==> ZAP-70(h):CD3zeta-isoform1(h){pY}2 (binding) | CD3zeta(h){pY72}{pY83} + ZAP-70(h) <==> CD3zeta(h){pY72}{pY83}:ZAP-70(h) (binding) | ZAP-70(h){p} --CD148(h)--> ZAP-70(h) + p (dephosphorylation) | ZAP70(h) --> ZAP-70(h) (expression). | ZAP-70(h){pY} --SHP-1L(h)--> ZAP-70(h) + p (dephosphorylation) | ZAP-70(h){pY} --SHP1-isoform1(h)--> ZAP-70(h) + p (dephosphorylation) | Lnk(m) + ATP --ZAP-70(h)--> Lnk(m){p} + ADP (phosphorylation) | HIP-55(h) + 2 ATP --ZAP-70(h)--> HIP-55(h){pY334}{pY344} + 2 ADP (phosphorylation) | SLP-76(h) + ATP --ZAP-70(h)--> SLP-76(h){pY} + ADP (phosphorylation) | SLP-76(h) + ATP --ZAP-70(h)--> SLP-76(h){pY} + ADP (phosphorylation) | MBP(m.s.) + ATP --ZAP-70(h)--> MBP(m.s.){p} + ADP (phosphorylation) | ErbB1-p170(h){pY998} + ZAP-70-isoform1(h) <==> ErbB1-p170(h){pY998}:ZAP-70-isoform1(h) (binding) | ErbB2(h) + ZAP-70-isoform1(h) <==> ErbB2(h):ZAP-70-isoform1(h) (binding) | ZAP-70-isoform1(h) + ErbB3-isoform1(h){pY1276} <==> ZAP-70-isoform1(h):ErbB3-isoform1(h){pY1276} (binding) | ZAP-70-isoform1(h) + 2 ATP --Lck-L(h){pY394}{pY505}--> ZAP-70-isoform1(h){pY319}{pY493} + 2 ADP (phosphorylation) | ZAP-70-isoform1(h) + ATP --> ZAP-70-isoform1(h){pY292} + ADP (phosphorylation) | ZAP-70-isoform1(h) + CD3zeta(h){pY72}{pY83} <==> ZAP-70-isoform1(h):CD3zeta(h){pY72}{pY83} (binding) | ZAP70(h) --> ZAP-70-isoform1(h) (expression). | ZAP-70-isoform1(h){pY493} --PEP(h)--> ZAP-70-isoform1(h) + p (dephosphorylation) | EMPB3(h) + ATP --ZAP-70-isoform1(h)--> EMPB3(h){p} + ADP (phosphorylation) | ZAP70(h) --> ZAP-70-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 248 | Phosphotyrosine. | Swiss-Prot 53.0 | 289 | Phosphoserine. | Swiss-Prot 53.0 | 292 | Phosphotyrosine. | Swiss-Prot 53.0 | 315 | Phosphotyrosine. | Swiss-Prot 53.0 | 319 | Phosphotyrosine. | Swiss-Prot 53.0 | 492 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 493 | Phosphotyrosine. | Swiss-Prot 53.0 | 292 | Phosphotyrosine (Lck;ZAP70) | 8756661;7961936;15144186;15592455;16094384;1565955 | Phospho.ELM 6.0 | 319 | Phosphotyrosine (Abl) | 10202147;10318843;12522270;15592455;16094384;10037 | Phospho.ELM 6.0 | 315 | Phosphotyrosine (ZAP70) | 11828374;7798261;12522270;15592455;16094384;100377 | Phospho.ELM 6.0 | 126 | Phosphotyrosine (ZAP70) | 7961936 | Phospho.ELM 6.0 | 289 | Phosphoserine | 15144186 | Phospho.ELM 6.0 | 248 | Phosphotyrosine | 15592455;15659558 | Phospho.ELM 6.0 | 474 | Phosphotyrosine (Lck) | 9685404 | Phospho.ELM 6.0 | 492 | Phosphotyrosine (Lck;ZAP70) | 8756661;7961936;7642520;12522270;15592455;11270871 | Phospho.ELM 6.0 | 493 | Phosphotyrosine (Lck;ZAP70) | 8756661;7961936;7642520;12522270;15144186;15592455 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 97715801 - 97717801 | Agilent_014791 |
chr2 |
Promoter: 97694963 - 97696963 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 97715801 - 97717801 | GSE27584 |
chr2 |
Promoter: 97694963 - 97696963 | GSE27584 |
chr2 |
Promoter: 97694963 - 97696963 | PMID:16079107 |
chr2 |
Promoter: 97715801 - 97717801 | PMID:16079107 |