| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 7535 |
Name | ZAP70 |
Synonym | SRK|STD|TZK|ZAP-70;zeta-chain (TCR) associated protein kinase 70kDa;ZAP70;zeta-chain (TCR) associated protein kinase 70kDa |
Definition | 70 kDa zeta-associated protein|70 kDa zeta-chain associated protein|syk-related tyrosine kinase|tyrosine-protein kinase ZAP-70|zeta-chain associated protein kinase, 70kD |
Position | 2q12 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | lck and fyn tyrosine kinases in initiation of tcr activation;PID BioCarta;100023 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor;PID BioCarta;100196 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | TCR signaling;PID Reactome;500478 |
Pathway | role of mef2d in t-cell apoptosis;PID BioCarta;100109 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | Generation of second messenger molecules;PID Reactome;500481 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | Translocation of ZAP-70 to Immunological synapse;PID Reactome;500480 |
Pathway | Primary immunodeficiency;KEGG PATHWAY;hsa05340 |
Disease | Combined immunodeficiencies;KEGG DISEASE;H00093 |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Selective T-cell defect;OMIM |
Disease | Primary immunodeficiency;KEGG DISEASE |
External Links | |
Links to Entrez Gene | 7535 |
Links to all GeneRIF Items | 7535 |
Links to iHOP | 7535 |
Sequence Information | |
Nucleotide Sequence | >7535 : length: 1860 atgccagaccccgcggcgcacctgcccttcttctacggcagcatctcgcgtgccgaggcc gaggagcacctgaagctggcgggcatggcggacgggctcttcctgctgcgccagtgcctg cgctcgctgggcggctatgtgctgtcgctcgtgcacgatgtgcgcttccaccactttccc atcgagcgccagctcaacggcacctacgccattgccggcggcaaagcgcactgtggaccg gcagagctctgcgagttctactcgcgcgaccccgacgggctgccctgcaacctgcgcaag ccgtgcaaccggccgtcgggcctcgagccgcagccgggggtcttcgactgcctgcgagac gccatggtgcgtgactacgtgcgccagacgtggaagctggagggcgaggccctggagcag gccatcatcagccaggccccgcaggtggagaagctcattgctacgacggcccacgagcgg atgccctggtaccacagcagcctgacgcgtgaggaggccgagcgcaaactttactctggg gcgcagaccgacggcaagttcctgctgaggccgcggaaggagcagggcacatacgccctg tccctcatctatgggaagacggtgtaccactacctcatcagccaagacaaggcgggcaag tactgcattcccgagggcaccaagtttgacacgctctggcagctggtggagtatctgaag ctgaaggcggacgggctcatctactgcctgaaggaggcctgccccaacagcagtgccagc aacgcctcaggggctgctgctcccacactcccagcccacccatccacgttgactcatcct cagagacgaatcgacaccctcaactcagatggatacacccctgagccagcacgcataacg tccccagacaaaccgcggccgatgcccatggacacgagcgtgtatgagagcccctacagc gacccagaggagctcaaggacaagaagctcttcctgaagcgcgataacctcctcatagct gacattgaacttggctgcggcaactttggctcagtgcgccagggcgtgtaccgcatgcgc aagaagcagatcgacgtggccatcaaggtgctgaagcagggcacggagaaggcagacacg gaagagatgatgcgcgaggcgcagatcatgcaccagctggacaacccctacatcgtgcgg ctcattggcgtctgccaggccgaggccctcatgctggtcatggagatggctgggggcggg ccgctgcacaagttcctggtcggcaagagggaggagatccctgtgagcaatgtggccgag ctgctgcaccaggtgtccatggggatgaagtacctggaggagaagaactttgtgcaccgt gacctggcggcccgcaacgtcctgctggttaaccggcactacgccaagatcagcgacttt ggcctctccaaagcactgggtgccgacgacagctactacactgcccgctcagcagggaag tggccgctcaagtggtacgcacccgaatgcatcaacttccgcaagttctccagccgcagc gatgtctggagctatggggtcaccatgtgggaggccttgtcctacggccagaagccctac aagaagatgaaagggccggaggtcatggccttcatcgagcagggcaagcggatggagtgc ccaccagagtgtccacccgaactgtacgcactcatgagtgactgctggatctacaagtgg gaggatcgccccgacttcctgaccgtggagcagcgcatgcgagcctgttactacagcctg gccagcaaggtggaagggcccccaggcagcacacagaaggctgaggctgcctgtgcctga |
Protein Sequence | >7535 : length: 619 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL ASKVEGPPGSTQKAEAACA |