| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 7535 |
Name | ZAP70 |
Synonymous | SRK|STD|TZK|ZAP-70;zeta-chain (TCR) associated protein kinase 70kDa;ZAP70;zeta-chain (TCR) associated protein kinase 70kDa |
Definition | 70 kDa zeta-associated protein|70 kDa zeta-chain associated protein|syk-related tyrosine kinase|tyrosine-protein kinase ZAP-70|zeta-chain associated protein kinase, 70kD |
Position | 2q12 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
in same component |
B2M | NCI_NATURE; |
in same component |
CBL | NCI_NATURE; |
in same component |
CD247 | NCI_NATURE; |
in same component |
CD3D | NCI_NATURE; |
in same component |
CD3D | REACTOME; |
in same component |
CD3E | NCI_NATURE; |
in same component |
CD3E | REACTOME; |
in same component |
CD3G | NCI_NATURE; |
in same component |
CD3G | REACTOME; |
in same component |
CD4 | NCI_NATURE; |
in same component |
CD4 | REACTOME; |
in same component |
CD8A | NCI_NATURE; |
in same component |
CD8B | NCI_NATURE; |
in same component |
HLA-A | NCI_NATURE; |
in same component |
HLA-DRA | NCI_NATURE; |
in same component |
HLA-DRB1 | NCI_NATURE; |
in same component |
LCK | NCI_NATURE; |
in same component |
LCK | REACTOME; |
in same component |
SH3BP2 | NCI_NATURE; |
in same component |
SLA2 | NCI_NATURE; |
in same component |
VAV2 | IMID; |
interacts with |
ABL1 | BIOGRID; |
interacts with |
ACP1 | BIOGRID; |
interacts with |
CARD11 | HPRD; |
interacts with |
CBLB | BIOGRID; |
interacts with |
CBLB | HPRD; |
interacts with |
CBL | BIOGRID; |
interacts with |
CBL | HPRD; |
interacts with |
CD247 | BIOGRID; |
interacts with |
CD247 | HPRD; |
interacts with |
CD247 | MINT; |
interacts with |
Cd3e | BIOGRID; |
interacts with |
CD3E | BIOGRID; |
interacts with |
CD3E | HPRD; |
interacts with |
CD3E | MINT; |
interacts with |
CD4 | BIOGRID; |
interacts with |
CD5 | BIOGRID; |
interacts with |
CD5 | HPRD; |
interacts with |
CD79B | HPRD; |
interacts with |
CRK | BIOGRID; |
interacts with |
CRK | HPRD; |
interacts with |
CRK | MINT; |
interacts with |
DBNL | BIOGRID; |
interacts with |
DBNL | HPRD; |
interacts with |
DEF6 | HPRD; |
interacts with |
DUSP3 | HPRD; |
interacts with |
EGFR | MINT; |
interacts with |
ERBB3 | MINT; |
interacts with |
FCGR3A | HPRD; |
interacts with |
FCRL3 | BIOGRID; |
interacts with |
FCRL3 | HPRD; |
interacts with |
FYN | BIOGRID; |
interacts with |
FYN | HPRD; |
interacts with |
GAB2 | BIOGRID; |
interacts with |
GAB2 | HPRD; |
interacts with |
HSP90AA1 | MINT; |
interacts with |
IFNAR1 | HPRD; |
interacts with |
LAT | BIOGRID; |
interacts with |
LAT | HPRD; |
interacts with |
LAT | MINT; |
interacts with |
LAX1 | HPRD; |
interacts with |
LCK | BIOGRID; |
interacts with |
LCK | HPRD; |
interacts with |
LCK | MINT; |
interacts with |
LCP2 | BIOGRID; |
interacts with |
LCP2 | HPRD; |
interacts with |
NFAM1 | HPRD; |
interacts with |
PAG1 | BIOGRID; |
interacts with |
PAG1 | HPRD; |
interacts with |
PLCG1 | BIOGRID; |
interacts with |
PRLR | HPRD; |
interacts with |
PTK2B | HPRD; |
interacts with |
PTPN22 | HPRD; |
interacts with |
PTPN6 | BIOGRID; |
interacts with |
PTPN6 | HPRD; |
interacts with |
PTPRC | HPRD; |
interacts with |
RASA1 | BIOGRID; |
interacts with |
RASA1 | HPRD; |
interacts with |
SH2B3 | HPRD; |
interacts with |
SH3BP2 | BIOGRID; |
interacts with |
SH3BP2 | HPRD; |
interacts with |
SHB | BIOGRID; |
interacts with |
SHB | HPRD; |
interacts with |
SHC1 | BIOGRID; |
interacts with |
SHC1 | HPRD; |
interacts with |
SHC1 | MINT; |
interacts with |
SIT1 | BIOGRID; |
interacts with |
SIT1 | HPRD; |
interacts with |
SLA2 | BIOGRID; |
interacts with |
SLA2 | HPRD; |
interacts with |
SLA | BIOGRID; |
interacts with |
SLA | HPRD; |
interacts with |
SOS1 | HPRD; |
interacts with |
TUBA4A | HPRD; |
interacts with |
TUBB | HPRD; |
interacts with |
TYROBP | BIOGRID; |
interacts with |
TYROBP | HPRD; |
interacts with |
UBE2L3 | HPRD; |
interacts with |
VAV1 | BIOGRID; |
interacts with |
VAV1 | HPRD; |
interacts with |
VAV1 | MINT; |
interacts with |
WIPF1 | HPRD; |
Metabolic Interaction [Top] | ||
There is no record for ZAP70 | ||
Signaling Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
reacts with |
B2M | NCI_NATURE; |
reacts with |
CBL | NCI_NATURE; |
reacts with |
CD247 | NCI_NATURE; |
reacts with |
CD3D | NCI_NATURE; |
reacts with |
CD3D | REACTOME; |
reacts with |
CD3E | NCI_NATURE; |
reacts with |
CD3E | REACTOME; |
reacts with |
CD3G | NCI_NATURE; |
reacts with |
CD3G | REACTOME; |
reacts with |
CD4 | NCI_NATURE; |
reacts with |
CD4 | REACTOME; |
reacts with |
CD8A | NCI_NATURE; |
reacts with |
CD8B | NCI_NATURE; |
reacts with |
HLA-A | NCI_NATURE; |
reacts with |
HLA-DRA | NCI_NATURE; |
reacts with |
HLA-DRB1 | NCI_NATURE; |
reacts with |
LCK | NCI_NATURE; |
reacts with |
LCK | REACTOME; |
reacts with |
SH3BP2 | NCI_NATURE; |
reacts with |
SLA2 | NCI_NATURE; |
reacts with |
VAV2 | IMID; |
reacts with |
ZAP70 | IMID; |
reacts with |
ZAP70 | NCI_NATURE; |
reacts with |
ZAP70 | REACTOME; |
state change |
CD28 | NCI_NATURE; |
state change |
CD3D | REACTOME; |
state change |
CD3E | REACTOME; |
state change |
CD3G | REACTOME; |
state change |
CD4 | REACTOME; |
state change |
LCK | REACTOME; |
state change |
PTPN6 | NCI_NATURE; |
state change |
ZAP70 | REACTOME; |