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Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7535

Name

ZAP70

Synonymous

SRK|STD|TZK|ZAP-70;zeta-chain (TCR) associated protein kinase 70kDa;ZAP70;zeta-chain (TCR) associated protein kinase 70kDa

Definition

70 kDa zeta-associated protein|70 kDa zeta-chain associated protein|syk-related tyrosine kinase|tyrosine-protein kinase ZAP-70|zeta-chain associated protein kinase, 70kD

Position

2q12

Gene Type

protein-coding

Gene Mutation:

PCGP germline mutation
PCGP somatic mutation
COSMIC somatic mutation

PCGP germline mutation   [Top]

There is no record for ZAP70

PCGP somatic mutation   [Top]

There is no record for ZAP70

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

c.188G>A; p.R63H;

lungcarcinoma; squamous_cell_carcinoma

c.1775G>A; p.R592H;

upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinoma

c.1484C>T; p.A495V; 2:97720653-97720653

 lungcarcinoma; adenocarcinoma

c.529C>T; p.L177F;

NSmalignant_melanoma

c.529C>T; p.L177F;

NSmalignant_melanoma

c.917G>A; p.R306Q;

large_intestine; coloncarcinoma; adenocarcinoma

c.673G>A; p.E225K;

large_intestine; coloncarcinoma; adenocarcinoma

c.1394G>A; p.R465H;

large_intestine; coloncarcinoma; adenocarcinoma

c.337G>A; p.G113R;

large_intestine; coloncarcinoma; adenocarcinoma

c.225A>C; p.K75N;

large_intestine; coloncarcinoma; adenocarcinoma

c.853G>A; p.D285N;

large_intestine; coloncarcinoma; adenocarcinoma

c.1541G>A; p.R514H;

large_intestine; coloncarcinoma; adenocarcinoma

c.1700A>C; p.E567A;

large_intestine; coloncarcinoma; adenocarcinoma

c.175delT; p.I61fs*108;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma

c.920C>T; p.P307L;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma

c.935C>T; p.T312M;

oesophaguscarcinoma; adenocarcinoma

c.1343G>A; p.G448E; 2:97720421-97720421

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinoma

c.1163A>T; p.Q388L;

lungcarcinoma; adenocarcinoma

c.1605C>T; p.Y535Y;

lungcarcinoma; adenocarcinoma

c.1290G>T; p.R430S;

lungcarcinoma; adenocarcinoma

c.573G>A; p.P191P;

central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastoma

c.249C>T; p.L83L; 2:97707180-97707180

 lungcarcinoma; non_small_cell_carcinoma

c.249C>T; p.L83L; 2:97707180-97707180

 lungcarcinoma; non_small_cell_carcinoma

c.692C>T; p.T231M;

prostateadenoma

c.828G>T; p.T276T;

lungcarcinoma; adenocarcinoma

c.356G>A; p.R119Q;

lungcarcinoma; squamous_cell_carcinoma

c.908A>G; p.D303G; 2:97717433-97717433

 ovarycarcinoma; serous_carcinoma

c.1068G>C; p.V356V;

lungcarcinoma; squamous_cell_carcinoma

c.1262C>A; p.P421Q;

lungcarcinoma; squamous_cell_carcinoma

c.1139C>A; p.T380K;

lungcarcinoma; squamous_cell_carcinoma

c.555C>A; p.G185G;

lungcarcinoma; squamous_cell_carcinoma

c.1453G>T; p.A485S;

lungcarcinoma; adenocarcinoma

c.1533C>A; p.I511I;

lungcarcinoma; adenocarcinoma

c.1111C>A; p.L371M;

lungcarcinoma; squamous_cell_carcinoma

c.536C>T; p.S179F;

lungcarcinoma; adenocarcinoma

c.1194C>A; p.I398I;

lung; right_upper_lobecarcinoma; adenocarcinoma

c.572C>T; p.P191L;

lungcarcinoma; squamous_cell_carcinoma

c.1388C>T; p.A463V;

lung; middle_lobecarcinoma; adenocarcinoma

c.1670G>A; p.R557Q;

breastcarcinoma

c.543G>A; p.A181A;

large_intestine; coloncarcinoma; adenocarcinoma

c.1708G>A; p.A570T;

large_intestine; coloncarcinoma; adenocarcinoma

c.413T>C; p.L138P;

large_intestine; coloncarcinoma; adenocarcinoma

c.479G>A; p.R160Q;

large_intestine; coloncarcinoma; adenocarcinoma

c.1540C>T; p.R514C;

large_intestine; coloncarcinoma; adenocarcinoma

c.507G>A; p.T169T;

large_intestine; coloncarcinoma; adenocarcinoma

c.1570A>G; p.S524G;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.1707C>T; p.Y569Y;

breastcarcinoma

c.1194C>T; p.I398I;

endometriumcarcinoma; endometrioid_carcinoma

c.1483-1G>T; p.?;

endometriumcarcinoma; endometrioid_carcinoma

c.1560C>T; p.S520S;

endometriumcarcinoma; endometrioid_carcinoma

c.1530C>T; p.C510C;

endometriumcarcinoma; endometrioid_carcinoma

c.1394G>A; p.R465H;

endometriumcarcinoma; endometrioid_carcinoma

c.1561G>A; p.D521N;

endometriumcarcinoma; endometrioid_carcinoma

c.1780C>T; p.R594*;

endometriumcarcinoma; endometrioid_carcinoma

c.121C>T; p.R41C;

large_intestine; caecumcarcinoma; adenocarcinoma

c.441G>A; p.P147P;

large_intestine; caecumcarcinoma; adenocarcinoma

c.1000C>T; p.R334C;

large_intestine; coloncarcinoma; adenocarcinoma

c.1548C>A; p.F516L;

endometriumcarcinoma; endometrioid_carcinoma

c.1237G>A; p.V413I;

endometriumcarcinoma; endometrioid_carcinoma

c.1525G>A; p.E509K;

endometriumcarcinoma; endometrioid_carcinoma

c.441G>A; p.P147P;

large_intestine; coloncarcinoma; adenocarcinoma

c.355C>T; p.R119*;

large_intestine; caecumcarcinoma; adenocarcinoma

c.121C>T; p.R41C;

large_intestine; caecumcarcinoma; adenocarcinoma

c.80C>T; p.A27V;

large_intestine; coloncarcinoma; adenocarcinoma

c.1124C>T; p.T375M;

large_intestine; coloncarcinoma; adenocarcinoma

c.1124C>T; p.T375M;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.1340T>C; p.M447T;

endometriumcarcinoma; endometrioid_carcinoma

c.1657G>A; p.E553K;

endometriumcarcinoma; endometrioid_carcinoma

c.216C>T; p.A72A;

urinary_tract; bladdercarcinoma

c.1669C>T; p.R557W;

breastcarcinoma

c.1038C>T; p.C346C;

prostatecarcinoma; adenocarcinoma

c.1637C>T; p.P546L;

large_intestine; coloncarcinoma; adenocarcinoma

c.1422C>T; p.Y474Y;

prostatecarcinoma

c.902C>T; p.S301F;

skinmalignant_melanoma

c.1822C>T; p.P608S;

skinmalignant_melanoma

c.551A>G; p.D184G;

skinmalignant_melanoma

c.1840G>A; p.A614T;

skin; scalpcarcinoma; squamous_cell_carcinoma

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