| General information | Literature | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 3562 |
Name | IL3 |
Synonymous | IL-3|MCGF|MULTI-CSF;interleukin 3 (colony-stimulating factor, multiple);IL3;interleukin 3 (colony-stimulating factor, multiple) |
Definition | P-cell stimulating factor|P-cell-stimulating factor|hematopoietic growth factor|interleukin-3|mast cell growth factor|mast-cell growth factor|multilineage-colony-stimulating factor|multipotential colony-stimulating factor |
Position | 5q31.1 |
Gene type | protein-coding |
Cancer type | Abstract |
| Acute megakaryoblastic leukemia;Hematological | Multidrug resistance is a severe clinical problem in the chemotherapy of malignant disease. Acute megakaryoblastic leukemia (AMKL) is a rare form of childhood leukemia, and is often resistant to many anti-cancer chemotherapeutic drugs. Here we report the expression of the mdr-1/P-glycoprotein in a cell line,CMK, established from a patient with AMKL. expression of mdr-1 mRNA in CMK11-5 cells, a well differentiated subline, was higher than in CMK6 cells, a poorly differentiated subline. The level of P-glycoprotein was also higher in CMK11-5 cells. The cytokines interferon-gamma (IFN-gamma), GM-CSF and IL-3, which were shown to induce megakaryocytic differentiation of CMK cells, enhanced the expression of the mdr-1 mRNA and levels of P-glycoprotein. These results imply that differentiated megakaryocytic cells may have higher levels of the P-glycoprotein expression, suggesting a possible normal physiological function of P-glycoprotein in mature megakaryocytes. |