| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3562 |
Name | IL3 |
Synonymous | IL-3|MCGF|MULTI-CSF;interleukin 3 (colony-stimulating factor, multiple);IL3;interleukin 3 (colony-stimulating factor, multiple) |
Definition | P-cell stimulating factor|P-cell-stimulating factor|hematopoietic growth factor|interleukin-3|mast cell growth factor|mast-cell growth factor|multilineage-colony-stimulating factor|multipotential colony-stimulating factor |
Position | 5q31.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IL3(h) --> IL-3(h) (expression). | IL-3(h) + IL-3Ralpha(h) + IL-5Rbeta(h) <==> IL-3(h):IL-3Ralpha(h):IL-5Rbeta(h) (binding) | IL-3(h) --> IL-5Rbeta-isoform1(h){pS601} (increase of phosphorylation) | IL-3(h) --> IL-5Rbeta(h){pS601} (increase of phosphorylation) | IL-3(h) --> ERK2(m){p} (increase of phosphorylation) | IL-3(h) --> STAT5(m){p} (increase of phosphorylation) | IL-3(h) --> AKT(m){p} (increase of phosphorylation) | IL-3(h) --> Jak2(m){pY} (increase of phosphorylation) | IL-3(h) --> IL-5Rbeta-isoform1(h):14-3-3(m) (increase of binding) | IL-3(h) --> IL-5Rbeta(h){pS601}:14-3-3(h) (increase of binding) | IL-3(h) --> IL-3Ralpha(h):IL-5Rbeta-isoform1(h) (increase of binding) | IL-3(h) + IL-5Rbeta-isoform1(h) <==> IL-3(h):IL-5Rbeta-isoform1(h) (binding) | IL-3(h) --> IL-5Rbeta-isoform1(h){pY} (increase of phosphorylation) | IL-3(h) --> ERK1(m){pT203} (increase of phosphorylation) | IL-3(h) --> ERK2(m){pY185} (increase of phosphorylation) | IL-3(h) --> AKT-1(m){pS473} (increase of phosphorylation) | IL-3(h) --> STAT5A(m){pY694} (increase of phosphorylation) | IL-3(h) --> Jak2(m){pY1007}{pY1008} (increase of phosphorylation) | IL-3(h) --> CREB1(h){pS133} (increase of phosphorylation) | IL3(h) --> IL-3(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 34 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 89 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr5 |
Promoter: 131422746 - 131424746 | GoldenGate_Methylation_Cancer_Panel_I |
chr5 |
Promoter: 131422746 - 131424746 | GSE27584 |