| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 836 |
Name | CASP3 |
Synonymous | CPP32|CPP32B|SCA-1;caspase 3, apoptosis-related cysteine peptidase;CASP3;caspase 3, apoptosis-related cysteine peptidase |
Definition | CASP-3|CPP-32|PARP cleavage protease|SREBP cleavage activity 1|Yama|apopain|caspase 3, apoptosis-related cysteine protease|caspase-3|cysteine protease CPP32|procaspase3|protein Yama |
Position | 4q34 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | proCaspase-3(h) --Caspase-9(h)--> Caspase-3(h) (processing) | proCaspase-3(h) --> Caspase-3-p12(h) + Caspase-3-p17(h) + protein remnants (processing) | proCaspase-3(h) --Caspase-8(h)--> Caspase-3(h) + protein remnants (processing) | proCaspase-3(h) --granzymeB(h)--> Caspase-3-p20(h) + Caspase-3-p12(h) (processing) | proCaspase-3(h) + Hsp10(h) + Hsp60(h) <==> proCaspase-3(h):Hsp10(h):Hsp60(h) (binding) | XIAP(h) + proCaspase-3(h) <==> XIAP(h):proCaspase-3(h) (binding) | proCaspase-3(h) --Caspase-9(h)--> Caspase-3(h) + protein remnants (processing) | Apaf-1(h) + proCaspase-9(h) + proCaspase-3(h) <==> Apaf-1(h):proCaspase-9(h):proCaspase-3(h) (binding) | proCaspase-3(h) --Caspase-6(h)--> Caspase-3-p20(h) + Caspase-3-p12(h) (processing) | p38alpha(h) + proCaspase-3(h) <==> p38alpha(h):proCaspase-3(h) (binding) | p38alpha(h){p} + proCaspase-3(h) <==> p38alpha(h){p}:proCaspase-3(h) (binding) | proCaspase-3(h) --granzymeB(r)--> Caspase-3-p17(h) + Caspase-3-p12(h) + protein remnants (processing) | proCaspase-3(h) + XIAP(h) + Cytochrome C(h) + Apaf-1(h) + proCaspase-9(h) <==> proCaspase-3(h):XIAP(h):Cytochrome C(h):Apaf-1(h):proCaspase-9(h) (binding) | Hsp60(h) + proCaspase-3(h) <==> Hsp60(h):proCaspase-3(h) (binding) | proCaspase-6(h) + Hsp60(h) + proCaspase-3(h) <==> proCaspase-6(h):Hsp60(h):proCaspase-3(h) (binding) | proCaspase-3(h) --Caspase-8(h)--> Caspase-3-p19(h) + Caspase-3-p12(h) + protein remnants (processing) | proCaspase-3(h) --Caspase-10(h)--> Caspase-3-p20(h) + Caspase-3-p12(h) + protein remnants (processing) | proCaspase-3(h) --Caspase-10a(h)--> Caspase-3-p17(h) + Caspase-3-p12(h) + Caspase-3-p20(h) + protein remnants (processing) | proCaspase-3(h) --Caspase-8a(h)--> Caspase-3-p17(h) + Caspase-3-p12(h) + Caspase-3-p20(h) + protein remnants (processing) | proCaspase-3(h) --Caspase-2(h)--> Caspase-3-p17(h) + protein remnants (cleavage) | proCaspase-3(h) --Caspase-2(h)--> Caspase-3-p20(h) + protein remnants (cleavage) | proCaspase-3(h) --> Caspase-3-p17(h) + protein remnants (processing) | proCaspase-3(h) --> Caspase-3-p19(h) + protein remnants (processing) | proCaspase-3(h) --> Caspase-3(h) + protein remnants (cleavage) | proCaspase-3(h) --> Caspase-3-p12(h) + protein remnants (processing) | proCaspase-3(h) + ATP --> proCaspase-3(h){p} + ADP (phosphorylation) | PKCdelta(h) + proCaspase-3(h) <==> PKCdelta(h):proCaspase-3(h) (binding) | proCaspase-3(h) --> Caspase-3-p21(h) + protein remnants (processing) | proCaspase-3(h) --> Caspase-3-p18(h) + protein remnants (processing) | proCaspase-3(h) --> Caspase-3-p17(h) + Caspase-3-p12(h) + protein remnants (processing) | proCaspase-3(h) --> Caspase-3-p20(h) + protein remnants (processing) | proCaspase-3(h) --> Caspase-3-p24(h) + protein remnants (cleavage) | proCaspase-2(h) + proCaspase-9(h) + Apaf-1(h) + proCaspase-3(h) <==> proCaspase-2(h):proCaspase-9(h):Apaf-1(h):proCaspase-3(h) (binding) | proCaspase-3(h) --> Caspase-3-p16(h) + protein remnants (processing) | proCaspase-3(h) --> protein remnants (processing) | proCaspase-3(h) --Caspase-8(h)--> protein remnants (processing) | proCaspase-3(h) --Caspase-10(h)--> protein remnants (processing) | proCaspase-3(h) --> Caspase3-p11(h) + protein remnants (cleavage) | proCaspase-3(h) --Caspase-8(h)--> Caspase-3-p18(h) + protein remnants (processing) | proCaspase-3(h) --Caspase-8(h)--> Caspase-3-p16(h) + protein remnants (processing) | proCaspase-3(h) + Hsp27(h) <==> proCaspase-3(h):Hsp27(h) (binding) | proCaspase-3(h) --> Caspase-3-p17(h) + protein remnants (cleavage) | proCaspase-3(h) --> Caspase-3-p17(h) + Caspase-3-p19(h) + protein remnants (cleavage) | proCaspase-3(h) --> Caspase-3-p17(h) + Caspase-3-p19(h) (cleavage) | proCaspase-3(h) --granzymeB(h)--> Caspase-3-p19(h) + Caspase-3-p17(h) (cleavage) | proCaspase-3(h) --> Caspase-3-p10(h) + protein remnants (cleavage) | Trx1(h){reC}2 --> proCaspase-3(h) (processing) | G{re} --> proCaspase-3(h) (activation; processing) | CASP3(h) --> proCaspase-3(h) (expression). | MST1(h) --> proCaspase-3(h) (activation) | Daxx(h) --> proCaspase-3(h) (increase of processing) | Fas(h) --> proCaspase-3(h) (increase of processing) | HCV-core-1B(HCV1B) --> proCaspase-3(h) (increase of cleavage) | Smac-delta(h) --> proCaspase-3(h) (increase of processing) | XIAP(m.s.) --> proCaspase-3(h) (decrease of processing) | Cdk5(h) --> proCaspase-3(h) (decrease of cleavage) | NADE-isoform1(m) --> proCaspase-3(h) (increase of cleavage) | E2F-7(h) --/ proCaspase-3(h) (decrease of abundance) | E2F-8(h) --/ proCaspase-3(h) (decrease of abundance) | rrp1b(h) --> proCaspase-3(h) (transactivation) | proCaspase-3(h) + ATP --PKCdelta(h)--> proCaspase-3(h){p} + ADP (phosphorylation) | CASP3(h) --> proCaspase-3(h) (expression). | GFAP(h) --proCaspase-3(h)--> GFAP-p20(h) + protein remnants (cleavage) | GFAP(h) --proCaspase-3(h)--> GFAP-p30(h) + protein remnants (cleavage) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 26 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 150 | Phosphoserine (MAPK14) | 14970175 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr4 |
Promoter: 185807123 - 185809123 | GoldenGate_Methylation_Cancer_Panel_I |
chr4 |
Promoter: 185807123 - 185809123 | GoldenGate_Methylation_Cancer_Panel_I |
chr4 |
Promoter: 185807123 - 185809123 | GSE27584 |
chr4 |
Promoter: 185807123 - 185809123 | GSE27584 |
chr4 |
Promoter: 185807123 - 185809123 | Agilent_014791_44K |
chr4 |
Promoter: 185807123 - 185809123 | Agilent_014791 |
chr4 |
Promoter: 185807123 - 185809123 | PMID:16435073 |
chr4 |
Promoter: 185807123 - 185809123 | PMID:16435073 |