| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 7153 |
Name | TOP2A |
Synonymous | TOP2|TP2A;topoisomerase (DNA) II alpha 170kDa;TOP2A;topoisomerase (DNA) II alpha 170kDa |
Definition | DNA gyrase|DNA topoisomerase (ATP-hydrolyzing)|DNA topoisomerase 2-alpha|DNA topoisomerase II, 170 kD|DNA topoisomerase II, alpha isozyme |
Position | 17q21-q22 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | topoisomerase-II-alpha(h) + topoisomerase-II-alpha(h) <==> topoisomerase-II-alpha(h):topoisomerase-II-alpha(h) (binding) | topoisomerase-II-alpha(h) + HDAC1(h) <==> topoisomerase-II-alpha(h):HDAC1(h) (binding) | topoisomerase-II-alpha(h) + HDAC1(m.s.) <==> topoisomerase-II-alpha(h):HDAC1(m.s.) (binding) | CREB1(h) + topoisomerase-II-alpha(h) <==> topoisomerase-II-alpha(h):CREB1(h) (binding) | topoisomerase-II-alpha(h) + ATF-2-xbb4(h) <==> topoisomerase-II-alpha(h):ATF-2-xbb4(h) (binding) | 2 topoisomerase-II-alpha(h) <==> (topoisomerase-II-alpha(h))2 (oligomerization) | topoisomerase-II-alpha(h) + c-Jun(m.s.) <==> c-Jun(m.s.):topoisomerase-II-alpha(h) (binding) | topoisomerase-II-alpha(h) + ATP --Aurora-B(h)--> topoisomerase-II-alpha(h){p} + ADP (phosphorylation) | topoisomerase-II-alpha(h) + Ubc9(h) <==> topoisomerase-II-alpha(h):Ubc9(h) (binding) | topoisomerase-II-alpha(h) + sumo1(h) --> topoisomerase-II-alpha(h){sumo} (sumoylation) | pRb(m.s.) + topoisomerase-II-alpha(h) <==> pRb(m.s.):topoisomerase-II-alpha(h) (binding) | topoisomerase-II-alpha(h) + brca1(m.s.) <==> topoisomerase-II-alpha(h):brca1(m.s.) (binding) | topoisomerase-II-alpha(h) + n ubiquitin(h) --brca1(m.s.)--> topoisomerase-II-alpha(h){ub}n (ubiquitination) | topoisomerase-II-alpha(h) + n ubiquitin(h) --> topoisomerase-II-alpha(h){ub}n (ubiquitination) | topoisomerase-II-alpha(h) + MO15(h) <==> topoisomerase-II-alpha(h):MO15(h) (binding) | HMGB1(r) + topoisomerase-II-alpha(h) <==> HMGB1(r):topoisomerase-II-alpha(h) (binding) | topoisomerase-II-alpha(h) + NFBD1(m.s.) <==> topoisomerase-II-alpha(h):NFBD1(m.s.) (binding) | topoisomerase-II-alpha(h) + NFBD1(h) <==> topoisomerase-II-alpha(h):NFBD1(h) (binding) | topoisomerase-II-alpha(h) + ATP --> topoisomerase-II-alpha(h){pS1524} + ADP (phosphorylation) | TOP2A(h) --> topoisomerase-II-alpha(h) (expression). | topoisomerase-II-alpha-isoform1(h) + ATP --Aurora-B(h)--> topoisomerase-II-alpha-isoform1(h){p} + ADP (phosphorylation) | topoisomerase-II-alpha-isoform1(h) + Ubc9(h) <==> topoisomerase-II-alpha-isoform1(h):Ubc9(h) (binding) | NFBD1(m.s.) + topoisomerase-II-alpha-isoform1(h) <==> NFBD1(m.s.):topoisomerase-II-alpha-isoform1(h) (binding) | NFBD1(h) + topoisomerase-II-alpha-isoform1(h) <==> NFBD1(h):topoisomerase-II-alpha-isoform1(h) (binding) | topoisomerase-II-alpha-isoform1(h) + ATP --> topoisomerase-II-alpha-isoform1(h){pS1525} + ADP (phosphorylation) | TOP2A(h) --> topoisomerase-II-alpha-isoform1(h) (expression). | TOP2A(h) --> topoisomerase-II-alpha-isoform2(h) (expression). | TOP2A(h) --> topoisomerase-II-alpha-isoform3(h) (expression). | TOP2A(h) --> topoisomerase-II-alpha-isoform4(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 4 | Phosphoserine. | Swiss-Prot 53.0 | 29 | Phosphoserine. | Swiss-Prot 53.0 | 1106 | Phosphoserine. | Swiss-Prot 53.0 | 1213 | Phosphoserine. | Swiss-Prot 53.0 | 1247 | Phosphoserine. | Swiss-Prot 53.0 | 1295 | Phosphoserine. | Swiss-Prot 53.0 | 1297 | Phosphoserine. | Swiss-Prot 53.0 | 1332 | Phosphoserine. | Swiss-Prot 53.0 | 1337 | Phosphoserine. | Swiss-Prot 53.0 | 1343 | Phosphothreonine. | Swiss-Prot 53.0 | 1351 | Phosphoserine. | Swiss-Prot 53.0 | 1354 | Phosphoserine. | Swiss-Prot 53.0 | 1374 | Phosphoserine. | Swiss-Prot 53.0 | 1377 | Phosphoserine. | Swiss-Prot 53.0 | 1387 | Phosphoserine. | Swiss-Prot 53.0 | 1393 | Phosphoserine. | Swiss-Prot 53.0 | 1469 | Phosphoserine (by CK2). | Swiss-Prot 53.0 | 1470 | Phosphothreonine. | Swiss-Prot 53.0 | 1471 | Phosphoserine. | Swiss-Prot 53.0 | 1474 | Phosphoserine. | Swiss-Prot 53.0 | 1525 | Phosphoserine. | Swiss-Prot 53.0 | 1213 | Phosphoserine (CDK1;MAPK1;M) | 7635160;16565220;17081983 | Phospho.ELM 6.0 | 1247 | Phosphoserine (CDK1;MAPK1;M) | 7635160;16565220;17081983 | Phospho.ELM 6.0 | 1474 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 1354 | Phosphoserine (CDK1;MAPK1;M) | 7635160;16565220;17081983 | Phospho.ELM 6.0 | 1361 | Phosphoserine (CDK1;MAPK1;M) | 7635160 | Phospho.ELM 6.0 | 4 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1332 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1337 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1393 | Phosphoserine (CDK1;MAPK1;M) | 7635160;16565220;17081983 | Phospho.ELM 6.0 | 1106 | Phosphoserine | 16565220;17081983 | Phospho.ELM 6.0 | 1295 | Phosphoserine | 16565220 | Phospho.ELM 6.0 | 1297 | Phosphoserine | 16565220 | Phospho.ELM 6.0 | 1374 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1351 | Phosphoserine | 16565220;17081983 | Phospho.ELM 6.0 | 1387 | Phosphoserine | 16565220 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr17 |
Promoter: 35827195 - 35829195 | Agilent_014791 |
chr17 |
Promoter: 35827195 - 35829195 | GSE27584 |