| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 7153 |
Name | TOP2A |
Synonymous | TOP2|TP2A;topoisomerase (DNA) II alpha 170kDa;TOP2A;topoisomerase (DNA) II alpha 170kDa |
Definition | DNA gyrase|DNA topoisomerase (ATP-hydrolyzing)|DNA topoisomerase 2-alpha|DNA topoisomerase II, 170 kD|DNA topoisomerase II, alpha isozyme |
Position | 17q21-q22 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for TOP2A | ||
PCGP somatic mutation [Top] | ||
There is no record for TOP2A | ||
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.4268G>T; p.S1423I; |
large_intestine | carcinoma; adenocarcinoma |
c.3197-1G>C; p.?; |
pancreas | carcinoma |
c.3049G>C; p.D1017H; |
pancreas | carcinoma |
c.1455T>C; p.P485P; |
pancreas | carcinoma |
c.3401G>C; p.W1134S; |
liver | carcinoma |
c.1176C>T; p.C392C; |
liver | carcinoma |
c.1167A>G; p.G389G; 17:35820923-35820923 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.763G>A; p.V255I; 17:35822563-35822563 |
skin | malignant_melanoma |
c.2425A>G; p.M809V; |
large_intestine | carcinoma; adenocarcinoma |
c.1266G>A; p.Q422Q; 17:35818346-35818346 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.22-10_22-9insT; p.?; |
oesophagus | carcinoma; adenocarcinoma |
c.22-10delt; p.?; |
oesophagus | carcinoma; adenocarcinoma |
c.2175T>G; p.G725G; |
liver | carcinoma |
c.1176C>T; p.C392C; |
liver | carcinoma |
c.963+8T>C; p.?; |
liver | carcinoma |
c.2641G>A; p.D881N; |
liver | carcinoma |
c.4449G>A; p.S1483S; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.3325G>A; p.E1109K; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.3197-1G>C; p.?; |
pancreas | carcinoma; ductal_carcinoma |
c.3049G>C; p.D1017H; |
pancreas | carcinoma; ductal_carcinoma |
c.1455T>C; p.P485P; |
pancreas | carcinoma; ductal_carcinoma |
c.457G>A; p.D153N; |
lung | carcinoma; adenocarcinoma |
c.1012G>T; p.V338F; |
lung | carcinoma; adenocarcinoma |
c.137G>C; p.R46P; |
lung | carcinoma; adenocarcinoma |
c.2632C>A; p.R878S; |
lung | carcinoma; adenocarcinoma |
c.2920G>T; p.E974*; |
lung | carcinoma; adenocarcinoma |
c.1204-9C>T; p.?; |
breast | carcinoma |
c.1426G>T; p.V476F; |
prostate | carcinoma |
c.3380A>G; p.Y1127C; |
ovary | carcinoma; serous_carcinoma |
c.803G>A; p.R268H; |
liver | carcinoma |
c.2206C>A; p.R736R; |
liver | carcinoma |
c.3800A>G; p.K1267R; |
liver | carcinoma |
c.1474A>G; p.N492D; |
liver | carcinoma |
c.3693A>G; p.A1231A; |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.3693A>C; p.A1231A; |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.4065A>C; p.P1355P; |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.3498G>T; p.L1166F; 17:35808375-35808375 |
ovary | carcinoma; serous_carcinoma |
c.1343G>T; p.G448V; |
lung | carcinoma; adenocarcinoma |
c.2135A>T; p.E712V; |
lung | carcinoma; adenocarcinoma |
c.4065A>C; p.P1355P; |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.4065A>C; p.P1355P; |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.636_638delAGA; p.E212delE; |
ovary | carcinoma; serous_carcinoma |
c.605_606insCTGG; p.E203fs*2; |
ovary | carcinoma; serous_carcinoma |
c.1063C>G; p.Q355E; 17:35821134-35821134 |
ovary | carcinoma; serous_carcinoma |
c.921C>G; p.G307G; 17:35821465-35821465 |
ovary | carcinoma; serous_carcinoma |
c.581_582insACATG; p.W194fs*1; |
ovary | carcinoma; serous_carcinoma |
c.600_601delAG; p.R200fs*3; |
ovary | carcinoma; serous_carcinoma |
c.2737G>A; p.V913I; 17:35810369-35810369 |
ovary | carcinoma; serous_carcinoma |
c.4417G>T; p.D1473Y; |
ovary | carcinoma; serous_carcinoma |
c.3350C>G; p.S1117C; |
lung | carcinoma; squamous_cell_carcinoma |
c.4383G>A; p.K1461K; |
lung | carcinoma; adenocarcinoma |
c.4476G>A; p.K1492K; |
lung | carcinoma; adenocarcinoma |
c.2762T>C; p.I921T; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.39G>A; p.M13I; |
lung | carcinoma; squamous_cell_carcinoma |
c.3627A>C; p.E1209D; |
lung | carcinoma; adenocarcinoma |
c.3447T>G; p.N1149K; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.3134C>T; p.S1045F; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.772A>T; p.N258Y; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.570C>G; p.F190L; |
breast | carcinoma |
c.3613delA; p.T1205fs*19; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3861delA; p.G1288fs*82; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.4526G>T; p.R1509L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.464A>T; p.E155V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3498G>T; p.L1166F; 17:35808375-35808375 |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.3624T>C; p.A1208A; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3176T>C; p.I1059T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1064A>G; p.Q355R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3867G>T; p.K1289N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3324C>T; p.N1108N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1165G>A; p.G389R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1063C>A; p.Q355K; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3725A>G; p.E1242G; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.3693A>T; p.A1231A; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.525C>A; p.T175T; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.2766A>C; p.E922D; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.3103G>T; p.E1035*; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.769C>T; p.L257F; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.3624T>C; p.A1208A; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3103G>T; p.E1035*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2769C>T; p.I923I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1462G>T; p.G488*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3325G>A; p.E1109K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.4303delA; p.R1435fs*13; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.4448C>T; p.S1483L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.4327A>C; p.R1443R; |
endometrium | carcinoma; endometrioid_carcinoma |
c.764T>C; p.V255A; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.4354T>C; p.S1452P; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3870G>A; p.K1290K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1193T>G; p.F398C; |
endometrium | carcinoma; endometrioid_carcinoma |
c.484C>T; p.R162*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2620A>C; p.N874H; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1914C>T; p.F638F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.4539A>G; p.V1513V; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.2763T>C; p.I921I; |
cervix | carcinoma; squamous_cell_carcinoma |
c.3047T>C; p.L1016S; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3214G>T; p.E1072*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1667T>G; p.F556C; |
endometrium | carcinoma; endometrioid_carcinoma |
c.265C>A; p.L89I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.95G>T; p.R32I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.684G>A; p.M228I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3529G>A; p.E1177K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.4449G>A; p.S1483S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.4383G>T; p.K1461N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.75G>T; p.K25N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.51A>C; p.K17N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.4594delT; p.*1532fs?; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.3613delA; p.T1205fs*19; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.3613delA; p.T1205fs*19; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.2738T>C; p.V913A; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3613delA; p.T1205fs*19; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1264C>T; p.Q422*; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.4535C>T; p.S1512F; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.764T>C; p.V255A; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.570C>G; p.F190L; |
urinary_tract; bladder | carcinoma |
c.2843A>G; p.E948G; |
breast | carcinoma |
c.764T>C; p.V255A; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2863A>G; p.T955A; |
urinary_tract; bladder | carcinoma |
c.3733G>A; p.E1245K; |
urinary_tract; bladder | carcinoma |
c.1015G>A; p.D339N; |
urinary_tract; bladder | carcinoma |
c.1433G>C; p.R478T; |
urinary_tract; bladder | carcinoma |
c.1166G>A; p.G389E; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.3351C>A; p.S1117S; |
prostate | carcinoma; adenocarcinoma |
c.918A>G; p.K306K; |
prostate | carcinoma; adenocarcinoma |
c.1368G>A; p.T456T; |
prostate | carcinoma |