| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 7099 |
Name | TLR4 |
Synonymous | ARMD10|CD284|TOLL|hToll;toll-like receptor 4;TLR4;toll-like receptor 4 |
Definition | homolog of Drosophila toll |
Position | 9q33.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | TLR4(h) + MD-2(h) <==> TLR4(h):MD-2(h) (binding) | LPS:LBP(rb):CD14(h) + TLR4(h) + MD-2(h) <==> LPS:LBP(rb):CD14(h):TLR4(h):MD-2(h) (binding) | CD14(h) + TLR4(h) <==> CD14(h):TLR4(h) (binding) | TLR4(h) + MyD88(h) <==> TLR4(h):MyD88(h) (binding) | TLR4(h) + TIRAP(h) <==> TLR4(h):TIRAP(h) (binding) | TLR4(h) + IRAK1(h) <==> TLR4(h):IRAK1(h) (binding) | TLR4(h) + IRAK-2(h) <==> TLR4(h):IRAK-2(h) (binding) | TLR4(h) + TRAM(h) <==> TLR4(h):TRAM(h) (binding) | TLR4(h) + TRAM(h) + TRIF(h) <==> TLR4(h):TRAM(h):TRIF(h) (binding) | TLR4(h) + Btk(h) <==> TLR4(h):Btk(h) (binding) | MD-2(h) + TLR4(h) <==> MD-2(h):TLR4(h) (binding) | TLR4(h) + NDP-Gly --> TLR4(h){gly} + NMP (glycosylation) | TLR4(h) + IRAK(h) <==> TLR4(h):IRAK(h) (binding) | TLR4(h) --> TLR4(h) (expression). | TLR4-isoform1(h) + tollip(m.s.) <==> tollip(m.s.):TLR4-isoform1(h) (binding) | TLR4-isoform1(h) + MyD88(h) <==> TLR4-isoform1(h):MyD88(h) (binding) | TIRAP(h) + TLR4-isoform1(h) <==> TIRAP(h):TLR4-isoform1(h) (binding) | TIRAP(m.s.) + TLR4-isoform1(h) <==> TIRAP(m.s.):TLR4-isoform1(h) (binding) | MyD88(m.s.) + TLR4-isoform1(h) <==> MyD88(m.s.):TLR4-isoform1(h) (binding) | TLR4-isoform1(h) + MD-2(h) <==> MD-2(h):TLR4-isoform1(h) (binding) | TLR2(h) + TLR4-isoform1(h) <==> TLR2(h):TLR4-isoform1(h) (binding) | TLR4-isoform1(h) + TRIAD3(h) <==> TRIAD3(h):TLR4-isoform1(h) (binding) | TLR4-isoform1(h) --> protein remnants (degradation) | TLR4-isoform1(h) --> TLR4-isoform1(h) (translocation) | TLR4(h) --> TLR4-isoform1(h) (expression). | TLR4-isoform1(h) --> TLR4-isoform1(h) (translocation) | TLR4(h) --> TLR4-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 35 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 173 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 205 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 282 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 309 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 497 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 526 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 575 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 624 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 630 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for TLR4 | ||