| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 7099 |
Name | TLR4 |
Synonymous | ARMD10|CD284|TOLL|hToll;toll-like receptor 4;TLR4;toll-like receptor 4 |
Definition | homolog of Drosophila toll |
Position | 9q33.1 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for TLR4 | ||
PCGP somatic mutation [Top] | ||
Variant (Variant; Chr; Position) | Genotype (MutationType; MutationClass; ReferenceAllele; Genotype; Origin) | Disease (CancerType; ValidationStatus; SequencingType) |
|---|---|---|
TLR4_L779L; chr9; 120476743 |
SUB; SILENT; C; C/A; SOMATIC | HYPO; PUTATIVE-HQ; EXOME |
TLR4_P214A; chr9; 120475046 |
SUB; MISSENSE; C; C/G; SOMATIC | RHB; VALID; WGS |
TLR4_P214A; chr9; 120475046 |
SUB; MISSENSE; C; C/G; SOMATIC | RHB; VALID; WGS |
TLR4_E4_exon; chr9; 120475046 |
SUB; EXON; C; C/G; SOMATIC | RHB; PUTATIVE-HQ; EXOME |
TLR4_E4_exon; chr9; 120475046 |
SUB; EXON; C; C/G; SOMATIC | RHB; PUTATIVE-HQ; WGS |
TLR4_E4_exon; chr9; 120475046 |
SUB; EXON; C; C/G; SOMATIC | RHB; PUTATIVE-HQ; EXOME |
TLR4_E4_exon; chr9; 120475046 |
SUB; EXON; C; C/G; SOMATIC | RHB; PUTATIVE-HQ; WGS |
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.2155G>T; p.A719S; |
liver | carcinoma; hepatocellular_carcinoma |
c.1515G>T; p.Q505H; |
lung | carcinoma; squamous_cell_carcinoma |
c.412C>A; p.L138I; |
lung | carcinoma; squamous_cell_carcinoma |
c.2274G>C; p.Q758H; |
lung | carcinoma; squamous_cell_carcinoma |
c.2383C>A; p.L795M; |
breast | carcinoma; ER-PR-positive_carcinoma |
c.1057C>T; p.L353F; |
skin; arm | malignant_melanoma |
c.1145G>T; p.R382I; |
lung | carcinoma; small_cell_carcinoma |
c.1610C>T; p.T537M; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1477A>G; p.T493A; |
lung | carcinoma; small_cell_carcinoma |
c.2233C>T; p.R745C; |
pancreas | carcinoma |
c.800G>A; p.G267E; |
lung | carcinoma; adenocarcinoma |
c.1895C>A; p.T632N; |
lung | carcinoma; adenocarcinoma |
c.1141A>T; p.S381C; |
lung | carcinoma; adenocarcinoma |
c.77G>T; p.W26L; |
lung | carcinoma; squamous_cell_carcinoma |
c.235G>C; p.E79Q; |
lung | carcinoma; adenocarcinoma |
c.487C>G; p.Q163E; |
lung | carcinoma; squamous_cell_carcinoma |
c.983A>T; p.Y328F; |
lung | carcinoma; small_cell_carcinoma |
c.337C>A; p.P113T; |
lung | carcinoma; undifferentiated_carcinoma |
c.973G>C; p.D325H; |
pancreas | carcinoma; acinar_carcinoma |
c.762A>C; p.E254D; |
oesophagus | carcinoma; adenocarcinoma |
c.1316A>G; p.E439G; |
oesophagus | carcinoma; adenocarcinoma |
c.1737T>C; p.N579N; |
oesophagus | carcinoma; adenocarcinoma |
c.2287C>T; p.R763C; |
oesophagus | carcinoma; adenocarcinoma |
c.1136A>G; p.D379G; |
oesophagus; lower_third | carcinoma; adenocarcinoma |
c.1459T>G; p.F487V; |
oesophagus | carcinoma; adenocarcinoma |
c.2456A>G; p.K819R; |
oesophagus; lower_third | carcinoma; adenocarcinoma |
c.1195A>G; p.T399A; |
oesophagus; lower_third | carcinoma; adenocarcinoma |
c.709T>G; p.F237V; |
oesophagus; lower_third | carcinoma; adenocarcinoma |
c.1243A>G; p.S415G; |
oesophagus | carcinoma; adenocarcinoma |
c.1877C>G; p.T626S; |
oesophagus | carcinoma; squamous_cell_carcinoma |
c.973G>T; p.D325Y; |
lung | carcinoma; adenocarcinoma |
c.660A>T; p.P220P; |
liver | carcinoma |
c.88G>A; p.V30M; |
upper_aerodigestive_tract; pharynx | carcinoma; squamous_cell_carcinoma |
c.1050C>G; p.L350L; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.891C>T; p.L297L; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.1673C>A; p.T558N; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.524C>A; p.T175N; |
upper_aerodigestive_tract; larynx | carcinoma; squamous_cell_carcinoma |
c.2233C>T; p.R745C; |
pancreas | carcinoma; ductal_carcinoma |
c.100C>T; p.P34S; |
skin; head_neck | malignant_melanoma; superficial_spreading |
c.1543G>A; p.A515T; |
skin; trunk | malignant_melanoma; nodular |
c.590T>A; p.V197D; |
lung | carcinoma; adenocarcinoma |
c.1498T>A; p.F500I; |
lung | carcinoma; adenocarcinoma |
c.1038C>A; p.P346P; |
lung | carcinoma; adenocarcinoma |
c.78G>T; p.W26C; |
lung | carcinoma; adenocarcinoma |
c.83C>A; p.P28H; |
lung | carcinoma; adenocarcinoma |
c.193C>A; p.P65T; |
lung | carcinoma; adenocarcinoma |
c.1256T>G; p.L419W; |
lung | carcinoma; adenocarcinoma |
c.433C>A; p.P145T; |
lung | carcinoma; adenocarcinoma |
c.2408G>A; p.G803E; |
lung | carcinoma; adenocarcinoma |
c.2025T>A; p.D675E; |
lung | carcinoma; adenocarcinoma |
c.477C>A; p.H159Q; |
lung | carcinoma; adenocarcinoma |
c.1439G>T; p.G480V; |
lung | carcinoma; adenocarcinoma |
c.1428G>T; p.L476F; |
lung | carcinoma; adenocarcinoma |
c.852C>A; p.T284T; |
lung | carcinoma; adenocarcinoma |
c.1135G>A; p.D379N; |
lung | carcinoma; adenocarcinoma |
c.1565T>C; p.L522P; |
lung | carcinoma; adenocarcinoma |
c.52C>T; p.L18F; |
lung | carcinoma; adenocarcinoma |
c.2411G>A; p.R804Q; |
lung | carcinoma; adenocarcinoma |
c.2191C>A; p.R731R; |
lung | carcinoma; adenocarcinoma |
c.1255T>A; p.L419M; |
lung | carcinoma; adenocarcinoma |
c.2411G>T; p.R804L; |
lung | carcinoma; adenocarcinoma |
c.405G>C; p.E135D; |
lung | carcinoma; adenocarcinoma |
c.835G>T; p.G279C; |
lung | carcinoma; adenocarcinoma |
c.1006G>T; p.E336*; |
lung | carcinoma; adenocarcinoma |
c.377C>T; p.S126L; |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma |
c.779T>C; p.L260P; |
lung | carcinoma; non_small_cell_carcinoma |
c.871G>A; p.A291T; |
breast | carcinoma; HER-positive_carcinoma |
c.235G>A; p.E79K; |
liver | carcinoma |
c.2382C>G; p.Y794*; |
lung | carcinoma; small_cell_carcinoma |
c.2142C>A; p.P714P; |
lung | carcinoma; small_cell_carcinoma |
c.1133T>G; p.L378R; |
central_nervous_system; brain | glioma |
c.845A>G; p.N282S; 9:119515072-119515072 |
ovary | carcinoma; serous_carcinoma |
c.2061G>A; p.W687*; |
lung | carcinoma; adenocarcinoma |
c.1974G>T; p.L658L; |
lung | carcinoma; adenocarcinoma |
c.1384G>C; p.A462P; |
lung | carcinoma; adenocarcinoma |
c.2392G>T; p.E798*; |
lung | carcinoma; adenocarcinoma |
c.337C>A; p.P113T; |
lung | carcinoma; adenocarcinoma |
c.2150_2151CC>AT; p.A717D; |
lung | carcinoma; adenocarcinoma |
c.1122C>A; p.S374R; |
lung | carcinoma; adenocarcinoma |
c.119G>T; p.C40F; 9:119510687-119510687 |
ovary | carcinoma; serous_carcinoma |
c.2440G>A; p.A814T; 9:119516667-119516667 |
ovary | carcinoma; serous_carcinoma |
c.659C>A; p.P220Q; |
lung | carcinoma; squamous_cell_carcinoma |
c.655C>A; p.Q219K; |
lung | carcinoma; squamous_cell_carcinoma |
c.161T>G; p.F54C; |
lung | carcinoma; squamous_cell_carcinoma |
c.1347C>T; p.L449L; |
lung | carcinoma; squamous_cell_carcinoma |
c.1407C>A; p.G469G; |
lung | carcinoma; squamous_cell_carcinoma |
c.1238C>G; p.T413S; |
lung | carcinoma; squamous_cell_carcinoma |
c.2489G>A; p.G830E; 9:119516716-119516716 |
ovary | carcinoma; serous_carcinoma |
c.963A>T; p.E321D; |
ovary | carcinoma; serous_carcinoma |
c.837C>A; p.G279G; |
lung | carcinoma; squamous_cell_carcinoma |
c.180C>G; p.D60E; |
lung | carcinoma; squamous_cell_carcinoma |
c.558G>C; p.K186N; |
lung | carcinoma; squamous_cell_carcinoma |
c.1244G>T; p.S415I; |
lung | carcinoma; adenocarcinoma |
c.1559C>A; p.S520Y; |
lung | carcinoma; adenocarcinoma |
c.2076A>G; p.L692L; |
lung | carcinoma; squamous_cell_carcinoma |
c.1051A>T; p.K351*; |
lung | carcinoma; squamous_cell_carcinoma |
c.1948C>T; p.L650L; |
lung | carcinoma; adenocarcinoma |
c.582C>G; p.D194E; |
lung | carcinoma; adenocarcinoma |
c.973G>T; p.D325Y; |
lung | carcinoma; adenocarcinoma |
c.2342A>G; p.Q781R; |
lung | carcinoma; adenocarcinoma |
c.1840G>A; p.D614N; |
lung | carcinoma; adenocarcinoma |
c.1609A>T; p.T537S; |
lung | carcinoma; adenocarcinoma |
c.1213G>A; p.D405N; |
lung | carcinoma; adenocarcinoma |
c.579A>C; p.T193T; |
lung | carcinoma; adenocarcinoma |
c.2095G>C; p.G699R; |
lung | carcinoma; adenocarcinoma |
c.2515A>T; p.I839F; |
lung; right_lower_lobe | carcinoma; adenocarcinoma |
c.1596C>A; p.F532L; |
lung | carcinoma; adenocarcinoma |
c.769C>T; p.R257C; |
lung | carcinoma; adenocarcinoma |
c.2410C>G; p.R804G; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.2410C>G; p.R804G; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.2232C>A; p.S744R; |
lung | carcinoma; adenocarcinoma |
c.174C>T; p.N58N; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.97G>T; p.V33F; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.138C>G; p.Y46*; |
lung; right_lower_lobe | carcinoma; adenocarcinoma |
c.2181C>A; p.F727L; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.916T>G; p.C306G; |
lung; right_lower_lobe | carcinoma; adenocarcinoma |
c.144C>A; p.I48I; |
lung | carcinoma; squamous_cell_carcinoma |
c.1912G>C; p.V638L; |
lung | carcinoma; squamous_cell_carcinoma |
c.2355G>C; p.L785L; |
ovary | carcinoma; serous_carcinoma |
c.2331C>T; p.T777T; |
lung | carcinoma; squamous_cell_carcinoma |
c.904G>C; p.D302H; |
lung | carcinoma; adenocarcinoma |
c.1748G>T; p.C583F; |
lung | carcinoma; squamous_cell_carcinoma |
c.948G>T; p.V316V; |
lung | carcinoma; squamous_cell_carcinoma |
c.2485A>C; p.T829P; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.742C>A; p.Q248K; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.2423_2424GG>TT; p.W808F; |
lung | carcinoma; adenocarcinoma |
c.2010T>A; p.G670G; |
lung | carcinoma; adenocarcinoma |
c.661G>A; p.G221S; |
lung | carcinoma; adenocarcinoma |
c.2042C>A; p.S681*; |
lung | carcinoma; adenocarcinoma |
c.1121G>C; p.S374T; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.2369G>A; p.S790N; |
lung; right_lower_lobe | carcinoma; adenocarcinoma |
c.867A>G; p.R289R; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.2238G>T; p.W746C; |
lung; right_lower_lobe | carcinoma; adenocarcinoma |
c.280G>T; p.E94*; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.196C>A; p.L66M; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.871G>C; p.A291P; |
lung | carcinoma; adenocarcinoma |
c.2240G>T; p.C747F; |
lung; right_lower_lobe | carcinoma; adenocarcinoma |
c.2148G>T; p.V716V; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.108T>A; p.I36I; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.1596C>G; p.F532L; |
breast | carcinoma |
c.283G>T; p.D95Y; |
breast | carcinoma |
c.1999T>A; p.Y667N; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.246G>A; p.V82V; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1484T>C; p.L495P; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1571T>A; p.V524E; |
breast | carcinoma |
c.569T>G; p.I190S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.550A>G; p.S184G; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.840G>C; p.L280L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.587G>A; p.R196Q; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1254C>A; p.F418L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2010T>C; p.G670G; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.506A>C; p.E169A; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.784G>T; p.E262*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1269A>C; p.Q423H; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1999T>C; p.Y667H; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.911_914delTTAA; p.N305fs*2; |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia |
c.1342A>C; p.N448H; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1817G>A; p.R606Q; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.2131G>T; p.D711Y; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1586A>G; p.H529R; |
breast | carcinoma |
c.922A>G; p.T308A; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2274G>T; p.Q758H; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1317G>A; p.E439E; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1449C>T; p.F483F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1671G>T; p.M557I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.990C>T; p.F330F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.491C>A; p.S164Y; |
endometrium | carcinoma; endometrioid_carcinoma |
c.632C>A; p.S211Y; |
endometrium | carcinoma; endometrioid_carcinoma |
c.705T>C; p.N235N; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1055C>A; p.S352Y; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1645C>A; p.L549I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2012A>G; p.E671G; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.984T>C; p.Y328Y; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.673G>T; p.E225*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.859G>T; p.E287*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1766G>A; p.S589N; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2192G>A; p.R731Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1543G>A; p.A515T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.973G>T; p.D325Y; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1103C>A; p.S368*; |
breast | carcinoma |
c.2370C>A; p.S790R; |
breast | carcinoma |
c.2410C>T; p.R804W; |
breast | carcinoma |
c.377C>T; p.S126L; |
breast | carcinoma |
c.377C>G; p.S126*; |
breast | carcinoma |
c.945G>C; p.L315L; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1006G>T; p.E336*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.760G>T; p.E254*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1817G>A; p.R606Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1296C>T; p.S432S; |
urinary_tract; bladder | carcinoma |
c.450A>C; p.K150N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.845A>G; p.N282S; 9:119515072-119515072 |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.2099T>C; p.V700A; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.120C>T; p.C40C; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2069A>G; p.N690S; |
endometrium | carcinoma; endometrioid_carcinoma |
c.784G>T; p.E262*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1661A>G; p.N554S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2050G>T; p.D684Y; |
breast | carcinoma |
c.644T>C; p.M215T; |
breast | carcinoma |
c.1438G>T; p.G480C; |
breast | carcinoma |
c.1948C>A; p.L650M; |
breast | carcinoma |
c.120C>A; p.C40*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1435G>A; p.A479T; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.2365C>G; p.L789V; |
urinary_tract; bladder | carcinoma |
c.1687G>A; p.E563K; |
skin; acral | malignant_melanoma |
c.2089G>A; p.E697K; |
skin | malignant_melanoma |
c.1150G>A; p.G384S; |
skin | malignant_melanoma |
c.1616C>T; p.P539L; |
skin | malignant_melanoma |
c.729G>A; p.M243I; |
skin | malignant_melanoma |
c.1573C>G; p.L525V; |
skin | malignant_melanoma |
c.673G>A; p.E225K; |
skin; neck | malignant_melanoma |
c.1702C>T; p.P568S; |
skin | malignant_melanoma |
c.866G>A; p.R289Q; |
skin; mucosal | malignant_melanoma |
c.1453G>A; p.E485K; |
skin; mucosal | malignant_melanoma |
c.865C>T; p.R289*; |
skin; mucosal | malignant_melanoma |
c.310C>T; p.L104F; |
skin; face | carcinoma; squamous_cell_carcinoma |
c.2488G>A; p.G830R; |
skin; scalp | carcinoma; squamous_cell_carcinoma |
c.145C>T; p.P49S; |
skin; ear | carcinoma; squamous_cell_carcinoma |
c.2392G>C; p.E798Q; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.148G>A; p.D50N; |
stomach | adenocarcinoma |
c.583T>G; p.L195V; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; diffuse_large_B_cell_lymphoma |