| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4233 |
Name | MET |
Synonymous | AUTS9|HGFR|RCCP2|c-Met;met proto-oncogene (hepatocyte growth factor receptor);MET;met proto-oncogene (hepatocyte growth factor receptor) |
Definition | HGF receptor|HGF/SF receptor|SF receptor|hepatocyte growth factor receptor|met proto-oncogene tyrosine kinase|oncogene MET|proto-oncogene c-Met|scatter factor receptor|tyrosine-protein kinase Met |
Position | 7q31 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | c-Met(h) + Fas(h) <==> c-Met(h):Fas(h) (binding) | c-Met(h) + ATP --> c-Met(h){p} + ADP (phosphorylation) | 14-3-3zeta(h) + c-Met(h) <==> 14-3-3zeta(h):c-Met(h) (binding) | c-Met(h) + Plexin-B1(h) <==> c-Met(h):Plexin-B1(h) (binding) | MET(h) --> c-Met(h) (expression). | Egr-1(h) --/ c-Met(h) (decrease of abundance) | alpha-MSH(m.s.) --> c-Met(h) (increase of abundance) | HGF(m.s.) --/ c-Met(h) (decrease of abundance) | MITF(h) --> c-Met(h) (increase of abundance) | MITF(m) --> c-Met(h) (increase of abundance) | MET(h) --> c-Met-isoform2(h) (expression). | c-Met-isoform1(h) + 2 ATP --> c-Met-isoform1(h){pY1234}{pY1235} + 2 ADP (phosphorylation) | c-Met-isoform1(h) --> ErbB2(h):Plexin-B1(m.s.) (decrease of binding) | Plexin-B1(h) + c-Met-isoform1(h) <==> Plexin-B1(h):c-Met-isoform1(h) (binding) | MET(h) --> c-Met-isoform1(h) (expression). | MET(h) --> MET(h) (expression). | hsa-miR-199a* --/ MET(h) (translational repression). | hsa-miR-34a --/ MET(h) (translational repression). | hsa-miR-1 --/ MET(h) (translational repression). | hsa-miR-206 --/ MET(h) (translational repression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 45 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 106 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 149 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 202 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 399 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 405 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 607 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 635 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 785 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 879 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 930 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 977 | Phosphothreonine. | Swiss-Prot 53.0 | 988 | Phosphoserine. | Swiss-Prot 53.0 | 990 | Phosphoserine. | Swiss-Prot 53.0 | 1003 | Phosphotyrosine. | Swiss-Prot 53.0 | 1235 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1356 | Phosphotyrosine (Met;Abl) | 12475979;9444958;9252406;7513258;7731718;8662889;7 | Phospho.ELM 6.0 | 1003 | Phosphotyrosine | 11741535 | Phospho.ELM 6.0 | 1365 | Phosphotyrosine | 12475979 | Phospho.ELM 6.0 | 1349 | Phosphotyrosine (Met;Abl) | 12475979;9444958;9252406;7513258;7731718;7687741;9 | Phospho.ELM 6.0 | 985 | Phosphoserine (PKC delta;PK) | 94124523;15075332;8294430 | Phospho.ELM 6.0 | 1230 | Phosphotyrosine (Met) | 12475979 | Phospho.ELM 6.0 | 1313 | Phosphotyrosine | 7708691;10069803 | Phospho.ELM 6.0 | 1235 | Phosphotyrosine (Met) | 1247597;8302603 | Phospho.ELM 6.0 | 1234 | Phosphotyrosine (Met) | 1247597;8302603;7961992 | Phospho.ELM 6.0 | 830 | Phosphotyrosine | 12746450 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr7 |
Promoter: 116098195 - 116100195 | Agilent_014791 |
chr7 |
Promoter: 116098195 - 116100195 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 116098195 - 116100195 | GSE27584 |
chr7 |
Promoter: 116098195 - 116100195 | Agilent_014791_44K |