| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 356 |
Name | FASLG |
Synonymous | APT1LG1|CD178|CD95-L|CD95L|FASL|TNFSF6;Fas ligand (TNF superfamily, member 6);FASLG;Fas ligand (TNF superfamily, member 6) |
Definition | APTL|CD95 ligand|apoptosis (APO-1) antigen ligand 1|apoptosis antigen ligand|fas antigen ligand|tumor necrosis factor (ligand) superfamily, member 6|tumor necrosis factor ligand superfamily member 6 |
Position | 1q23 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | FasL(h) + Fas(h) <==> FasL(h):Fas(h) (binding) | FasL(h) + Fas(m) <==> FasL(h):Fas(m) (binding) | FasL(h) + Grb-2(h) <==> FasL(h):Grb-2(h) (binding) | FasL(h) + FBP17(h) <==> FasL(h):FBP17(h) (binding) | FasL(h) + pacsin2(h) <==> FasL(h):pacsin2(h) (binding) | FasL(h) + pacsin2(m) <==> FasL(h):pacsin2(m) (binding) | FasL(h) + SDPIII(m) <==> FasL(h):SDPIII(m) (binding) | c-FLIP-L-p43(h) + FADD(h) + Fas(h) + FasL(h) + proCaspase-8(h) <==> FasL(h):Fas(h):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) (binding) | FasL(h) + Caspase-10(h) <==> FasL(h):Caspase-10(h) (binding) | FasL(h) + proCaspase-8(h) <==> FasL(h):proCaspase-8(h) (binding) | FasL(h) + FADD(h) <==> FasL(h):FADD(h) (binding) | FADD(h) + FasL(h) + Fas(h) + proCaspase-10(h) <==> FADD(h):FasL(h):Fas(h):proCaspase-10(h) (binding) | FADD(h) + FasL(h) + Fas(h) <==> FADD(h):FasL(h):Fas(h) (binding) | Fas(h) + FasL(h) + c-FLIP-S(m.s.) + FADD(h) + proCaspase-8(h) + c-FLIP-L-p43(h) <==> Fas(h):FasL(h):c-FLIP-S(m.s.):FADD(h):proCaspase-8(h):c-FLIP-L-p43(h) (binding) | Fas(h) + FasL(h) + FADD(h) + Caspase-8-p43(h) + c-FLIP-L-p43(m.s.) <==> Fas(h):FasL(h):FADD(h):Caspase-8-p43(h):c-FLIP-L-p43(m.s.) (binding) | FasL(h) + c-FLIP-L-p43(m.s.) + Caspase-8-p43(h) <==> FasL(h):c-FLIP-L-p43(m.s.):Caspase-8-p43(h) (binding) | FasL(h) + c-FLIP-S(m.s.) + proCaspase-8(h) <==> FasL(h):proCaspase-8(h):c-FLIP-S(m.s.) (binding) | FasL(h) + proCaspase-8(h) + c-FLIP-L-p43(h) + c-FLIP-S(m.s.) + RIP(h) <==> FasL(h):proCaspase-8(h):c-FLIP-L-p43(h):c-FLIP-S(m.s.):RIP(h) (binding) | FasL(h) + c-FLIP-L-p43(m.s.) + Caspase-8-p43(h) + RIP-p45(h) <==> FasL(h):c-FLIP-L-p43(m.s.):Caspase-8-p43(h):RIP-p45(h) (binding) | Caspase-8-p43(h) + FasL(h) + FADD(h) + Fas(h) <==> Caspase-8-p43(h):FasL(h):FADD(h):Fas(h) (binding) | FASLG(h) --> FasL(h) (expression). | Cdc42(h) --> FasL(h) (increase of abundance) | FOXO1A(m.s.) --> FasL(h) (increase of abundance) | proCaspase-10B(h) --FasL(h)--> Caspase-10a-p17(h) + Caspase-10a-p12(h) + protein remnants (processing) | proCaspase-10A(h) --FasL(h)--> Caspase-10b-p12(h) + Caspase-10b-p20(h) + protein remnants (processing) | proCaspase-10d(h) --FasL(h)--> Caspase-10d-p20(h) + Caspase-10d-p12(h) + protein remnants (processing) | proCaspase-8a(h) --FasL(h)--> Caspase-8a-p20(h) + Caspase-8a-p12(h) + protein remnants (processing) | FASLG(h) --> FasL-isoform1(h) (expression). | FASLG(h) --> FasL-isoform2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 184 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 250 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 260 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 170893308 - 170895308 | IlluminaMethylation27 |
chr1 |
Promoter: 170893308 - 170895308 | E-GEOD-20553 |