| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3558 |
Name | IL2 |
Synonymous | IL-2|TCGF|lymphokine;interleukin 2;IL2;interleukin 2 |
Definition | T cell growth factor|aldesleukin|interleukin-2|involved in regulation of T-cell clonal expansion |
Position | 4q26-q27 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IL-2(h) + IL-2Rbeta(h) <==> IL-2(h):IL-2Rbeta(h) (binding) | IL-2(h) + gamma-c(m):IL-2Rbeta(h) <==> IL-2(h):gamma-c(m):IL-2Rbeta(h) (binding) | IL2(h) --> IL-2(h) (expression). | KRC(m.s.) --> IL-2(h) (increase of abundance) | CD45(m) --> IL-2(h) (increase of abundance) | CD3(h) --> IL-2(h) (increase of secretion) | rps3(h) --> IL-2(h) (increase of abundance) | MALT1-isoform1(h) --> IL-2(h) (increase of secretion) | A20(h) --> IL-2(h) (decrease of secretion) | PTP-PEST(m) --> IL-2(h) (decrease of secretion) | RasGRP(h) --> IL-2(h) (increase of secretion) | IL-2(h) --> Jak3(h){pY} (increase of phosphorylation) | IL-2(h) --> VIL(h){pY} (increase of phosphorylation) | IL-2(h) --> Jak3(h):VIL(h) (increase of binding) | IL-2(h) --> FOXO1A(m){pT24} (increase of phosphorylation) | IL-2(h) --> ERK1(m){pT203}{pY205} (increase of phosphorylation) | IL-2(h) --> ERK2(m){pT183}{pY185} (increase of phosphorylation) | IL2(h) --> IL-2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 23 | O-linked | 1:Robb R., Kutny R., Panico M., Morris H. and Chowdhry V. (1984) Proc. Natl. Acad. Sci., 81, 6486-6490. Medline: 85038540;2:Vita N., Magazin M., Marchese E., Lupker J. and Ferrara, P. (1990) Lymphokine Res., 9, 67-79. Medline: 90219931; | OGlycBase6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for IL2 | ||