Entrez Gene

Pediatric cancer gene database (Pedican) Home

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	3558
Name	IL2
Synonymous	IL-2\|TCGF\|lymphokine;interleukin 2;IL2;interleukin 2
Definition	T cell growth factor\|aldesleukin\|interleukin-2\|involved in regulation of T-cell clonal expansion
Position	4q26-q27
Gene Type	protein-coding
Gene Interactions:	Physical Interaction Metabolic Interaction Signaling Interaction

Interaction Type	Interactor	Data Source
Physical Interaction [Top]
in same component	FYN	NCI_NATURE;
in same component	GAB2	NCI_NATURE;
in same component	IL2RA	NCI_NATURE;
in same component	IL2RA	REACTOME;
in same component	IL2RB	NCI_NATURE;
in same component	IL2RB	REACTOME;
in same component	IL2RG	NCI_NATURE;
in same component	IL2RG	REACTOME;
in same component	JAK1	NCI_NATURE;
in same component	JAK1	REACTOME;
in same component	JAK3	NCI_NATURE;
in same component	JAK3	REACTOME;
in same component	LCK	NCI_NATURE;
in same component	PIK3CA	NCI_NATURE;
in same component	PIK3R1	NCI_NATURE;
in same component	PTK2B	NCI_NATURE;
in same component	PTPN11	NCI_NATURE;
in same component	SHC1	NCI_NATURE;
in same component	SHC1	REACTOME;
in same component	SOS1	NCI_NATURE;
in same component	SYK	NCI_NATURE;
in same component	SYK	REACTOME;
interacts with	CD53	HPRD;
interacts with	DGKA	BIOGRID;
interacts with	FOXK2	HPRD;
interacts with	IFNA1	HPRD;
interacts with	IL21R	BIOGRID;
interacts with	IL2RA	HPRD;
interacts with	IL2RB	HPRD;
interacts with	IL2RG	HPRD;
interacts with	NGFR	HPRD;
interacts with	SHC1	HPRD;

Interaction Type	Interactor	Data Source
Metabolic Interaction [Top]
metabolic catalysis	BATF3	NCI_NATURE;
metabolic catalysis	CREM	NCI_NATURE;
metabolic catalysis	EBI3	NCI_NATURE;
metabolic catalysis	EGR2	NCI_NATURE;
metabolic catalysis	EGR3	NCI_NATURE;
metabolic catalysis	FOS	NCI_NATURE;
metabolic catalysis	FOSL1	NCI_NATURE;
metabolic catalysis	FOXP3	NCI_NATURE;
metabolic catalysis	IL27	NCI_NATURE;
metabolic catalysis	IL27RA	NCI_NATURE;
metabolic catalysis	IL6ST	NCI_NATURE;
metabolic catalysis	JAK2	NCI_NATURE;
metabolic catalysis	JUNB	NCI_NATURE;
metabolic catalysis	JUN	NCI_NATURE;
metabolic catalysis	MAPK9	NCI_NATURE;
metabolic catalysis	NFATC2	NCI_NATURE;
metabolic catalysis	PPARG	NCI_NATURE;
metabolic catalysis	RNF128	NCI_NATURE;
metabolic catalysis	STAT4	NCI_NATURE;
metabolic catalysis	TYK2	NCI_NATURE;

Interaction Type	Interactor	Data Source
Signaling Interaction [Top]
reacts with	FYN	NCI_NATURE;
reacts with	GAB2	NCI_NATURE;
reacts with	IL2	NCI_NATURE;
reacts with	IL2	REACTOME;
reacts with	IL2RA	NCI_NATURE;
reacts with	IL2RA	REACTOME;
reacts with	IL2RB	NCI_NATURE;
reacts with	IL2RB	REACTOME;
reacts with	IL2RG	NCI_NATURE;
reacts with	IL2RG	REACTOME;
reacts with	JAK1	NCI_NATURE;
reacts with	JAK1	REACTOME;
reacts with	JAK3	NCI_NATURE;
reacts with	JAK3	REACTOME;
reacts with	LCK	NCI_NATURE;
reacts with	PIK3CA	NCI_NATURE;
reacts with	PIK3R1	NCI_NATURE;
reacts with	PTK2B	NCI_NATURE;
reacts with	PTPN11	NCI_NATURE;
reacts with	SHC1	NCI_NATURE;
reacts with	SHC1	REACTOME;
reacts with	SOS1	NCI_NATURE;
reacts with	SYK	NCI_NATURE;
reacts with	SYK	REACTOME;
state change	B2M	NCI_NATURE;
state change	CD247	NCI_NATURE;
state change	CD3D	NCI_NATURE;
state change	CD3E	NCI_NATURE;
state change	CD3G	NCI_NATURE;
state change	CD8A	NCI_NATURE;
state change	CD8B	NCI_NATURE;
state change	CISH	NCI_NATURE;
state change	HLA-A	NCI_NATURE;
state change	IL2	REACTOME;
state change	IL2RA	REACTOME;
state change	IL2RB	NCI_NATURE;
state change	IL2RB	REACTOME;
state change	IL2RG	NCI_NATURE;
state change	IL2RG	REACTOME;
state change	JAK1	NCI_NATURE;
state change	JAK1	REACTOME;
state change	JAK3	NCI_NATURE;
state change	JAK3	REACTOME;
state change	LCK	NCI_NATURE;
state change	RHOA	NCI_NATURE;
state change	SOCS1	NCI_NATURE;
state change	SOCS3	NCI_NATURE;
state change	SYK	REACTOME;

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