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Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4361

Name

MRE11A

Synonymous

ATLD|HNGS1|MRE11|MRE11B;MRE11 meiotic recombination 11 homolog A (S. cerevisiae);MRE11A;MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Definition

AT-like disease|DNA recombination and repair protein|MRE11 homolog 1|MRE11 homolog A|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog 1|meiotic recombination 11 homolog A

Position

11q21

Gene Type

protein-coding

Gene Mutation:

PCGP germline mutation
PCGP somatic mutation
COSMIC somatic mutation

PCGP germline mutation   [Top]

There is no record for MRE11A

PCGP somatic mutation   [Top]

There is no record for MRE11A

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

c.694C>T; p.Q232*;

livercarcinoma; hepatocellular_carcinoma

c.237A>T; p.L79F;

livercarcinoma; hepatocellular_carcinoma

c.1146C>T; p.S382S;

breastcarcinoma; ER-PR-positive_carcinoma

c.710T>G; p.F237C; 11:93844523-93844523

 breastcarcinoma; ductal_carcinoma

c.314+6T>C; p.?;

livercarcinoma

c.1098+10A>G; p.?;

livercarcinoma

c.1651G>A; p.A551T;

lungcarcinoma; small_cell_carcinoma

c.256G>A; p.D86N;

lungcarcinoma; mucoepidermoid_carcinoma

c.853G>T; p.G285C;

lungcarcinoma; adenocarcinoma

c.742G>A; p.E248K;

lungcarcinoma; adenocarcinoma

c.1564-2A>T; p.?;

livercarcinoma; hepatocellular_carcinoma

c.904C>T; p.H302Y; 11:93843398-93843398

 breastcarcinoma; ductal_carcinoma

c.904C>T; p.H302Y; 11:93843398-93843398

 breastcarcinoma; ductal_carcinoma

c.568T>C; p.Y190H;

upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinoma

c.1559G>C; p.R520P;

lungcarcinoma; adenocarcinoma

c.530C>G; p.A177G;

lungcarcinoma; adenocarcinoma

c.928G>T; p.E310*;

lungcarcinoma; adenocarcinoma

c.1714C>T; p.R572*;

lungcarcinoma; adenocarcinoma

c.1777_1778GG>AA; p.G593K; 11:93820038-93820039

 lungcarcinoma; non_small_cell_carcinoma

c.315-4delt; p.?;

ovarycarcinoma; serous_carcinoma

c.1552G>T; p.E518*;

endometriumcarcinoma; serous_carcinoma

c.597A>T; p.T199T;

ovarycarcinoma; serous_carcinoma

c.1688C>T; p.S563L;

lungcarcinoma; squamous_cell_carcinoma

c.1327-2A>G; p.?;

ovarycarcinoma; serous_carcinoma

c.1746G>A; p.Q582Q;

lungcarcinoma; squamous_cell_carcinoma

c.616G>T; p.D206Y;

lungcarcinoma; adenocarcinoma

c.1043A>T; p.E348V;

lung; right_upper_lobecarcinoma; adenocarcinoma

c.157G>T; p.D53Y;

lungcarcinoma; adenocarcinoma

c.332A>C; p.Y111S;

lung; right_upper_lobecarcinoma; adenocarcinoma

c.366G>T; p.V122V;

lung; right_upper_lobecarcinoma; adenocarcinoma

c.1575G>T; p.R525S;

lung; right_upper_lobecarcinoma; adenocarcinoma

c.1521C>A; p.T507T;

large_intestine; coloncarcinoma; adenocarcinoma

c.894A>C; p.K298N;

large_intestine; caecumcarcinoma; adenocarcinoma

c.708C>T; p.D236D;

large_intestine; coloncarcinoma; adenocarcinoma

c.229G>A; p.E77K;

large_intestine; caecumcarcinoma; adenocarcinoma

c.151G>A; p.E51K;

large_intestine; caecumcarcinoma; adenocarcinoma

c.1429C>G; p.Q477E;

haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemia

c.1584A>G; p.A528A;

large_intestine; rectumcarcinoma; adenocarcinoma

c.863G>A; p.R288H;

large_intestine; rectumcarcinoma; adenocarcinoma

c.58G>T; p.D20Y;

large_intestine; rectumcarcinoma; adenocarcinoma

c.1820T>C; p.V607A;

large_intestine; rectumcarcinoma; adenocarcinoma

c.1505G>A; p.R502H;

large_intestine; rectumcarcinoma; adenocarcinoma

c.2010G>T; p.M670I;

large_intestine; rectumcarcinoma; adenocarcinoma

c.1959G>A; p.S653S;

endometriumcarcinoma; endometrioid_carcinoma

c.652C>A; p.Q218K;

breastcarcinoma

c.1640G>T; p.S547I;

endometriumcarcinoma; endometrioid_carcinoma

c.1582G>A; p.A528T;

endometriumcarcinoma; endometrioid_carcinoma

c.910G>A; p.V304M;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.1378G>T; p.E460*;

endometriumcarcinoma; endometrioid_carcinoma

c.449T>C; p.V150A;

endometriumcarcinoma; endometrioid_carcinoma

c.1959G>A; p.S653S;

endometriumcarcinoma; endometrioid_carcinoma

c.1287A>G; p.V429V;

breastcarcinoma

c.1351G>C; p.E451Q;

breastcarcinoma

c.1504C>T; p.R502C;

endometriumcarcinoma; endometrioid_carcinoma

c.1180G>T; p.D394Y;

large_intestine; coloncarcinoma; adenocarcinoma

c.1890C>T; p.T630T;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.710T>C; p.F237S;

large_intestine; caecumcarcinoma; adenocarcinoma

c.1757C>T; p.S586L;

large_intestine; coloncarcinoma; adenocarcinoma

c.709T>C; p.F237L;

large_intestine; coloncarcinoma; adenocarcinoma

c.1098+2T>A; p.?;

large_intestine; caecumcarcinoma; adenocarcinoma

c.710T>C; p.F237S;

large_intestine; coloncarcinoma; adenocarcinoma

c.904C>A; p.H302N;

large_intestine; coloncarcinoma; adenocarcinoma

c.282C>A; p.L94L;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.853G>T; p.G285C;

endometriumcarcinoma; endometrioid_carcinoma

c.1318G>A; p.A440T;

endometriumcarcinoma; endometrioid_carcinoma

c.763A>G; p.K255E;

endometriumcarcinoma; endometrioid_carcinoma

c.43A>C; p.I15L;

endometriumcarcinoma; endometrioid_carcinoma

c.710T>C; p.F237S;

large_intestine; coloncarcinoma; adenocarcinoma

c.1326+1G>C; p.?;

urinary_tract; bladdercarcinoma

c.709T>C; p.F237L;

large_intestine; coloncarcinoma; adenocarcinoma

c.1398G>A; p.E466E;

cervixcarcinoma; squamous_cell_carcinoma

c.1532delA; p.N511fs*13;

large_intestine; caecumcarcinoma; adenocarcinoma

c.1046G>T; p.R349L;

urinary_tract; bladdercarcinoma

c.711C>T; p.F237F;

large_intestine; coloncarcinoma; adenocarcinoma

c.709T>C; p.F237L;

large_intestine; caecumcarcinoma; adenocarcinoma

c.142C>T; p.Q48*;

skinmalignant_melanoma

c.1532delA; p.N511fs*13;

stomachadenocarcinoma

c.466T>C; p.S156P;

stomachadenocarcinoma

c.1795A>G; p.T599A;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphoma

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