| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4361 |
Name | MRE11A |
Synonym | ATLD|HNGS1|MRE11|MRE11B;MRE11 meiotic recombination 11 homolog A (S. cerevisiae);MRE11A;MRE11 meiotic recombination 11 homolog A (S. cerevisiae) |
Definition | AT-like disease|DNA recombination and repair protein|MRE11 homolog 1|MRE11 homolog A|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog 1|meiotic recombination 11 homolog A |
Position | 11q21 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Non-homologous end-joining;KEGG PATHWAY;hsa03450 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | BARD1 signaling events;PID Curated;200174 |
Pathway | Homologous recombination;KEGG PATHWAY;hsa03440 |
Pathway | DNA Repair;Reactome;REACT:216 |
Pathway | role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234 |
Pathway | Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks;PID Reactome;500950 |
Disease | Colon cancer;FunDO |
Disease | Adenovirus infection;FunDO |
Disease | Stomach cancer;FunDO |
Disease | Adenoma;FunDO |
Disease | Leukoencephalopathy;FunDO |
Disease | Ataxia telangiectasia;FunDO |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Ataxia-telangiectasia-like disorder;OMIM |
Disease | Lung cancer;FunDO |
Disease | DNA repair defect;KEGG DISEASE;H00094 |
Disease | Hodgkin's disease;FunDO |
Disease | Breast cancer;FunDO |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Alzheimer's disease;FunDO |
External Links | |
Links to Entrez Gene | 4361 |
Links to all GeneRIF Items | 4361 |
Links to iHOP | 4361 |
Sequence Information | |
Nucleotide Sequence | >4361 : length: 2043 atgagtactgcagatgcacttgatgatgaaaacacatttaaaatattagttgcaacagat attcatcttggatttatggagaaagatgcagtcagaggaaatgatacgtttgtaacactc gatgaaattttaagacttgcccaggaaaatgaagtggattttattttgttaggtggtgat ctttttcatgaaaataagccctcaaggaaaacattacatacctgcctcgagttattaaga aaatattgtatgggtgatcggcctgtccagtttgaaattctcagtgatcagtcagtcaac tttggttttagtaagtttccatgggtgaactatcaagatggcaacctcaacatttcaatt ccagtgtttagtattcatggcaatcatgacgatcccacaggggcagatgcactttgtgcc ttggacattttaagttgtgctggatttgtaaatcactttggacgttcaatgtctgtggag aagatagacattagtccggttttgcttcaaaaaggaagcacaaagattgcgctatatggt ttaggatccattccagatgaaaggctctatcgaatgtttgtcaataaaaaagtaacaatg ttgagaccaaaggaagatgagaactcttggtttaacttatttgtgattcatcagaacagg agtaaacatggaagtactaacttcattccagaacaatttttggatgacttcattgatctt gttatctggggccatgaacatgagtgtaaaatagctccaaccaaaaatgaacaacagctg ttttatatctcacaacctggaagctcagtggttacttctctttccccaggagaagctgta aagaaacatgttggtttgctgcgtattaaagggaggaagatgaatatgcataaaattcct cttcacacagtgcggcagtttttcatggaggatattgttctagctaatcatccagacatt tttaacccagataatcctaaagtaacccaagccatacaaagcttctgtttggagaagatt gaagaaatgcttgaaaatgctgaacgggaacgtctgggtaattctcaccagccagagaag cctcttgtacgactgcgagtggactatagtggaggttttgaacctttcagtgttcttcgc tttagccagaaatttgtggatcgggtagctaatccaaaagacattatccattttttcagg catagagaacaaaaggaaaaaacaggagaagagatcaactttgggaaacttatcacaaag ccttcagaaggaacaactttaagggtagaagatcttgtaaaacagtactttcaaaccgca gagaagaatgtgcagctctcactgctaacagaaagagggatgggtgaagcagtacaagaa tttgtggacaaggaggagaaagatgccattgaggaattagtgaaataccagttggaaaaa acacagcgatttcttaaagaacgtcatattgatgccctcgaagacaaaatcgatgaggag gtacgtcgtttcagagaaaccagacaaaaaaatactaatgaagaagatgatgaagtccgt gaggctatgaccagggccagagcactcagatctcagtcagaggagtctgcttctgccttt agtgctgatgaccttatgagtatagatttagcagaacagatggctaatgactctgatgat agcatctcagcagcaaccaacaaaggaagaggccgaggaagaggtcgaagaggtggaaga gggcagaattcagcatcgagaggagggtctcaaagaggaagagcctttaaatctacaaga cagcagccttcccgaaatgtcactactaagaattattcagaggtgattgaggtagatgaa tcagatgtggaagaagacatttttcctaccacttcaaagacagatcaaaggtggtccagc acatcatccagcaaaatcatgtcccagagtcaagtatcgaaaggggttgattttgaatca agtgaggatgatgatgatgatccttttatgaacactagttctttaagaagaaatagaaga taa |
Protein Sequence | >4361 : length: 680 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRAFKSTR QQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFES SEDDDDDPFMNTSSLRRNRR |