6778

STAT6

D12S1644|IL-4-STAT|STAT6B|STAT6C;signal transducer and activator of transcription 6, interleukin-4 induced;STAT6;signal transducer and activator of transcription 6, interleukin-4 induced

STAT, interleukin4-induced|signal transducer and activator of transcription 6|transcription factor IL-4 STAT

12q13

protein-coding

The immune system plays an important role in the control of cancer development. To investigate possible genetic contribution to childhood leukemia risk in the innate immune system, we performed an association study for the 1214 SNPs in 146gene regions related to innate immunity using GoldenGate (Illumina) oligonucleotide pool assay (OPA) in 106 case patients and 123 controls. childhood leukemia risk was estimated as odds ratios and 95% confidence intervals adjustedfor age, gender and birth weight. The minP test was used to identify statistically significant association at gene level. Three SNPs (STAT6 rs703817,C1qG rs17433222, and MBP rs3794845) were significantly associated with childhoodleukemia risk (p(trend) < 0.001, minP < 0.01). The most significant association with childhood leukemia risk was for STAT6 rs703817 (GA vs GG: 0.48 (0.26-0.87),AA vs GG: 0.21 (0.07-0.61), p(trend) = 0.0003, minP = 0.002). Subgroup analysis showed that Ly96 rs78380171 and MBP rs3794845 were significantly associated withthe risk of acute lymphoblastic leukemia (p(trend) < 0.001). Our results suggestthat genetic polymorphisms in innate immunity genes might play a role in the genesis of childhood leukemia with limited biologic evidence. Additional, largerstudies are needed to identify the mechanism of these genes in childhood leukemia patients.#CI- Copyright 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. ALL rights reserved.