| General information | Literature | Expression | Regulation | Mutation | Interaction |
Basic Information | |
|---|---|
Gene ID | 2067 |
Name | ERCC1 |
Synonymous | COFS4|RAD10|UV20;excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence);ERCC1;excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) |
Definition | DNA excision repair protein ERCC-1 |
Position | 19q13.32 |
Gene type | protein-coding |
Cancer type | Abstract |
| acute lymphoblastic leukemia;Hematological | Gene expression profiles of 10 children with acute lymphoblastic leukemia (ALL) were detected using cDNA arrays. Total RNAs were isolated from peripheral blood leukocytes of the patients at diagnosis. For detection of expression profiles weused Atlas Human cancer cDNA Arrays (Clontech) with 588 genes. Although the study revealed variability of gene expression in many genes, we identified a number ofgenes with the same expression changes (up-regulation: PCNA, ERCC1; down-regulation: jun-B, BCL-2 related protein A1, CRAF-1, PBP) in most examined patients. Our objective was to identify genes that were differentially expressedin ALL and might contribute to development (and characterization) of the disease. |