| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 7297 |
Name | TYK2 |
Synonymous | JTK1;tyrosine kinase 2;TYK2;tyrosine kinase 2 |
Definition | non-receptor tyrosine-protein kinase TYK2 |
Position | 19p13.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Tyk2(h) + ATP --protein tyrosine kinases(v.s.)--> Tyk2(h){pY} + ADP (phosphorylation) | IL-13Ralpha1(h) + Tyk2(h) <==> IL-13Ralpha1(h):Tyk2(h) (binding) | IFNAR1(h) + Tyk2(h) <==> IFNAR1(h):Tyk2(h) (binding) | Tyk2(h) + Jak1(h) <==> Tyk2(h):Jak1(h) (binding) | Tyk2(h) + Jak1(m) <==> Tyk2(h):Jak1(m) (binding) | 2 Tyk2(h) <==> Tyk2(h):Tyk2(h) (binding) | Tyk2(h) + ATP --Tyk2(h)--> Tyk2(h){pY} + ADP (phosphorylation) | Tyk2(h) + uPAR(h) <==> Tyk2(h):uPAR(h) (binding) | Tyk2(h) + ATP --> Tyk2(h){pY} + ADP (phosphorylation) | Tyk2(h) + ATP --> Tyk2(h){p} + ADP (phosphorylation) | IL-17A(h) --> Tyk2(h) (activation; phosphorylation) | TYK2(h) --> Tyk2(h) (expression). | Tyk2(h) + ATP --Tyk2(h)--> Tyk2(h){pY} + ADP (phosphorylation) | Tyk2(h) + ATP --> Tyk2(h){pY} + ADP (phosphorylation) | IFNAR1-isoform1(h) + Tyk2(h) <==> IFNAR1-isoform1(h):Tyk2(h) (binding) | Tyk2(h) + 2 ATP --> Tyk2(h){pY1054}{pY1055} + 2 ADP (phosphorylation) | Tyk2(h) + ATP --> Tyk2(h){p} + ADP (automodification) | Tyk2(h) + ATP --> Tyk2(h){pY292} + ADP (phosphorylation) | TYK2(h) --> Tyk2(h) (expression). | IFNAR1(h) + ATP --Tyk2(h)--> IFNAR1(h){p} + ADP (phosphorylation) | Beta-enolase(rb) + ATP --Tyk2(h)--> Beta-enolase(rb){p} + ADP (phosphorylation) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 1054 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1054 | Phosphotyrosine (Tyk2;JAK1) | 8702790;15659558;15659558 | Phospho.ELM 6.0 | 1055 | Phosphotyrosine (Tyk2;JAK1) | 8702790;15659558;15659558 | Phospho.ELM 6.0 | 292 | Phosphotyrosine | 15659558 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr19 |
Promoter: 10351711 - 10353711 | Agilent_014791 |
chr19 |
Promoter: 10351711 - 10353711 | GoldenGate_Methylation_Cancer_Panel_I |
chr19 |
Promoter: 10351711 - 10353711 | GSE27584 |
chr19 |
Promoter: 10351711 - 10353711 | Agilent_014791_44K |