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Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7297

Name

TYK2

Synonymous

JTK1;tyrosine kinase 2;TYK2;tyrosine kinase 2

Definition

non-receptor tyrosine-protein kinase TYK2

Position

19p13.2

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 EBI3NCI_NATURE;

in same component

 IFNAR1REACTOME;

in same component

 IL12ANCI_NATURE;

in same component

 IL12BNCI_NATURE;

in same component

 IL12RB1NCI_NATURE;

in same component

 IL12RB2NCI_NATURE;

in same component

 IL23ANCI_NATURE;

in same component

 IL23RNCI_NATURE;

in same component

 IL27RANCI_NATURE;

in same component

 IL27NCI_NATURE;

in same component

 IL6RNCI_NATURE;

in same component

 IL6STNCI_NATURE;

in same component

 IL6NCI_NATURE;

in same component

 JAK1REACTOME;

in same component

 JAK2NCI_NATURE;

in same component

 SOCS1NCI_NATURE;

in same component

 SOCS3NCI_NATURE;

in same component

 SPHK2NCI_NATURE;

in same component

 STAT2REACTOME;

interacts with

 CBLBIOGRID;

interacts with

 CBLHPRD;

interacts with

 CRKLBIOGRID;

interacts with

 CRKLHPRD;

interacts with

 EIF2AK2HPRD;

interacts with

 ELP2BIOGRID;

interacts with

 FYNBIOGRID;

interacts with

 FYNHPRD;

interacts with

 GHRBIOGRID;

interacts with

 GHRHPRD;

interacts with

 IFNAR1BIOGRID;

interacts with

 IFNAR1HPRD;

interacts with

 IFNAR1MINT;

interacts with

 IL13RA1BIOGRID;

interacts with

 IL6STBIOGRID;

interacts with

 IL6STHPRD;

interacts with

 IRS1HPRD;

interacts with

 IRS2BIOGRID;

interacts with

 IRS2HPRD;

interacts with

 JAK1BIOGRID;

interacts with

 JAK1HPRD;

interacts with

 JAK2HPRD;

interacts with

 JAKMIP1HPRD;

interacts with

 LYNBIOGRID;

interacts with

 LYNHPRD;

interacts with

 PDGFRBHPRD;

interacts with

 PIK3R1HPRD;

interacts with

 PLAURBIOGRID;

interacts with

 PLAURHPRD;

interacts with

 PRKCAMINT;

interacts with

 PRMT5BIOGRID;

interacts with

 PRMT5HPRD;

interacts with

 PTAFRHPRD;

interacts with

 PTPN1BIOGRID;

interacts with

 PTPN1HPRD;

interacts with

 PTPN1MINT;

interacts with

 PTPN6BIOGRID;

interacts with

 PTPN6HPRD;

interacts with

 PTPRCHPRD;

interacts with

 STAM2BIOGRID;

interacts with

 STAM2HPRD;

interacts with

 STAT1BIOGRID;

interacts with

 STAT1HPRD;

interacts with

 STAT2HPRD;

interacts with

 VAV1BIOGRID;

interacts with

 VAV1HPRD;

interacts with

 XRCC5BIOGRID;

interacts with

 XRCC5HPRD;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

sequential catalysis

 IFNAR1REACTOME;

sequential catalysis

 JAK1REACTOME;

sequential catalysis

 STAT2REACTOME;

sequential catalysis

 TYK2REACTOME;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 EBI3NCI_NATURE;

reacts with

 IFNAR1REACTOME;

reacts with

 IL12ANCI_NATURE;

reacts with

 IL12BNCI_NATURE;

reacts with

 IL12RB1NCI_NATURE;

reacts with

 IL12RB2NCI_NATURE;

reacts with

 IL23ANCI_NATURE;

reacts with

 IL23RNCI_NATURE;

reacts with

 IL27RANCI_NATURE;

reacts with

 IL27NCI_NATURE;

reacts with

 IL6RNCI_NATURE;

reacts with

 IL6STNCI_NATURE;

reacts with

 IL6NCI_NATURE;

reacts with

 JAK1REACTOME;

reacts with

 JAK2NCI_NATURE;

reacts with

 SOCS1NCI_NATURE;

reacts with

 SOCS3NCI_NATURE;

reacts with

 SPHK2NCI_NATURE;

reacts with

 STAT2REACTOME;

reacts with

 TYK2NCI_NATURE;

reacts with

 TYK2REACTOME;

state change

 IFNAR1REACTOME;

state change

 IL1BNCI_NATURE;

state change

 IL4NCI_NATURE;

state change

 JAK1REACTOME;

state change

 NOS2NCI_NATURE;

state change

 PTPN1NCI_NATURE;

state change

 PTPN6REACTOME;

state change

 STAT2REACTOME;

state change

 TYK2REACTOME;

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