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Pedican
Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7132

Name

TNFRSF1A

Synonymous

CD120a|FPF|TBP1|TNF-R|TNF-R-I|TNF-R55|TNFAR|TNFR1|TNFR55|TNFR60|p55|p55-R|p60;tumor necrosis factor receptor superfamily, member 1A;TNFRSF1A;tumor necrosis factor receptor superfamily, member 1A

Definition

TNF-R1|TNF-RI|TNFR-I|tumor necrosis factor binding protein 1|tumor necrosis factor receptor 1A isoform beta|tumor necrosis factor receptor superfamily member 1A|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor

Position

12p13.2

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Translational Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors   [Top]

Regulation From TransFac database

TNFR1(h) + TRADD(h) <==> TNFR1(h):TRADD(h) (binding)
3 TNF-alpha(h){sol} + TNFR1(h) <==> (TNF-alpha(h){sol})3:TNFR1(h) (binding)
TNFR1(h) + TRADD(h) + TRAF1(m) + TRAF2(m) <==> TNFR1(h):TRADD(h):TRAF1(m):TRAF2(m) (binding)
TNFR1(h) + MADD(h) <==> TNFR1(h):MADD(h) (binding)
TNFR1(h) + TRADD(h) + RIP(h) <==> TNFR1(h):TRADD(h):RIP(h) (binding)
TNFR1(h) + RIP(h) <==> TNFR1(h):RIP(h) (binding)
TNFR1(h) + SODD(h) <==> TNFR1(h):SODD(h) (binding)
TNFR1(h) + IKK-alpha(h) <==> TNFR1(h):IKK-alpha(h) (binding)
TNFR1(h) + IKK-beta(h) <==> TNFR1(h):IKK-beta(h) (binding)
TNFR1(h) + IKK-gamma(h) <==> TNFR1(h):IKK-gamma(h) (binding)
TNFR1(h) + A20(h) <==> TNFR1(h):A20(h) (binding)
TNFR1(h) + RIP(h) + A20(h) + IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2 <==> TNFR1(h):RIP(h):IKK-alpha(h):IKK-beta(h):(IKK-gamma(h))2:A20(h) (binding)
2 TNFR1(h) <==> TNFR1(h):TNFR1(h) (binding; oligomerization)
TNFR1(h) --> IL8(h) (transactivation)
TNFR1(h) + sumo1(h) <==> TNFR1(h):sumo1(h) (binding)
TNFR1(h) + TRADD(h) + RIP(h) + RIP3(h) <==> TNFR1(h):TRADD(h):RIP(h):RIP3(h) (binding)
Src(m) + TNFR1(h) <==> Src(m):TNFR1(h) (binding)
CIN85(m.s.) + Src(m) + TNFR1(h) <==> CIN85(m.s.):Src(m):TNFR1(h) (binding)
CIN85(m.s.) + TNFR1(h) <==> CIN85(m.s.):TNFR1(h) (binding)
CIN85(m.s.) + Src(h) + TNFR1(h) <==> CIN85(m.s.):Src(h):TNFR1(h) (binding)
TNFR1(h) + ARTS1(h) <==> TNFR1(h):ARTS1(h) (binding)
TNFR1(h) --> FAN(m.s.) (binding)
TNFR1(h) --> Fas(h) (binding)
TNFR1(h) --> proCaspase-8(h) (binding)
TNFR1(h) --> TRADD(h) (binding)
TNFR1(h) --> FADD(h) (binding)
TNFR1(h) --> TRAF2(h) (binding)
TNFR1(h) + TNF-alpha(m.s.) <==> TNFR1(h):TNF-alpha(m.s.) (binding)
TRADD(h) + TNFR1(h) + TRAF2(h) <==> TRADD(h):TNFR1(h):TRAF2(h) (binding)
TNFR1(h) + AIP1(h) <==> TNFR1(h):AIP1(h) (binding)
muc1(h) + TNFR1(h) <==> muc1(h):TNFR1(h) (binding)
TNFR1(h) + TAK1(h) <==> TNFR1(h):TAK1(h) (binding)
RIP3(h) + TNFR1(h) <==> RIP3(h):TNFR1(h) (binding)
TNFR1(h) + RIP(m.s.) <==> TNFR1(h):RIP(m.s.) (binding)
TNFR1(h) + TRAF2(h) <==> TNFR1(h):TRAF2(h) (binding)
TNFR1(h) + TRADD(h) + RIP(h) + TRAF2(h) <==> TNFR1(h):TRADD(h):RIP(h):TRAF2(h) (binding)
Jak1(h) + TNFR1(h) <==> Jak1(h):TNFR1(h) (binding)
TNFR1(h) + ATP --> TNFR1(h){p} + ADP (phosphorylation)
TNFR1(h) --> GluR3(h) (activation; increase of abundance)
TNFR1(h) --> NR1(h) (activation; increase of abundance)
RIP(h){ub}n + TNFR1(h) <==> RIP(h){ub}n:TNFR1(h) (binding)
TNFRSF1A(h) --> TNFR1(h) (expression).
TRADD(h) --> TNFR1(h) (binding)
TRAF2(h) --> TNFR1(h) (binding)
TNF-alpha(h) --> TNFR1(h) (binding)
RIP(h) + TNFR1(h) <==> RIP(h):TNFR1(h) (binding)
TNFR1(h) --> IKK-gamma(h) (increase of phosphorylation)
TNFRSF1A(h) --> TNFR1(h) (expression).

Post Translational Modification   [Top]

Location (AA)

PTM type

Literature

Database

54N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
145N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
151N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr12

Promoter: 6321022 - 6323022GoldenGate_Methylation_Cancer_Panel_I

chr12

Promoter: 6321022 - 6323022GSE27584


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