| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 627 |
Name | BDNF |
Synonymous | -;brain-derived neurotrophic factor;BDNF;brain-derived neurotrophic factor |
Definition | abrineurin|neurotrophin |
Position | 11p13 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | BDNF(h) --> ERK1(r){p} (increase of phosphorylation) | BDNF(h) --> ERK2(r){p} (increase of phosphorylation) | BDNF(h) --> FRS2(r){pY} (increase of phosphorylation) | BDNF(h) --> FRS2(h){pY} (increase of phosphorylation) | BDNF(h) --> Grb-2(r):FRS2(r) (increase of binding) | BDNF(h) --> Grb-2(h):FRS2(h) (increase of binding) | BDNF(h) --> BDNF(h) (expression). | c-Fos(r) --> BDNF(h) (increase of abundance) | PGE2 --> BDNF(h) (activation; increase of abundance) | BDNF(h) --> BDNF_01(h) (expression). | hsa-miR-1 --/ BDNF_01(h) (predicted) | hsa-miR-206 --/ BDNF_01(h) (predicted) | BDNF(h) --> BDNF_02(h) (expression). | hsa-miR-1 --/ BDNF_02(h) (predicted) | hsa-miR-206 --/ BDNF_02(h) (predicted) | BDNF(h) --> BDNF_03(h) (expression). | hsa-miR-1 --/ BDNF_03(h) (predicted) | hsa-miR-206 --/ BDNF_03(h) (predicted) | BDNF(h) --> BDNF_04(h) (expression). | hsa-miR-1 --/ BDNF_04(h) (predicted) | hsa-miR-206 --/ BDNF_04(h) (predicted) | BDNF(h) --> BDNF_05(h) (expression). | hsa-miR-1 --/ BDNF_05(h) (predicted) | hsa-miR-206 --/ BDNF_05(h) (predicted) | BDNF(h) --> BDNF_06(h) (expression). | hsa-miR-1 --/ BDNF_06(h) (predicted) | hsa-miR-206 --/ BDNF_06(h) (predicted) | sortilin(h) + BDNF(h) <==> sortilin(h):BDNF(h) (binding) | 2 BDNF(h) <==> (BDNF(h))2 (oligomerization) | trkB(h) + BDNF(h) <==> trkB(h):BDNF(h) (binding) | NT-3(h) + BDNF(h) <==> NT-3(h):BDNF(h) (binding) | NT-5(h) + BDNF(h) <==> NT-5(h):BDNF(h) (binding) | BDNF(h) --> Egr3(r) (transactivation) | BDNF(h) --> egr3(r) (increase of abundance) | BDNF(h) --> Gabra4(r) (increase of abundance) | BDNF(h) --> ERK1(r){p} (increase of phosphorylation) | BDNF(h) --> ERK2(r){p} (increase of phosphorylation) | BDNF(h) --> Ras(r):GTP:Raf-1(h) (increase of binding) | BDNF(h) --> AKT(r){p} (increase of phosphorylation) | BDNF(h) --> FRS2(h):SHP-2(h) (increase of binding) | BDNF(h) --> FRS2(r):SHP-2(r) (increase of binding) | BDNF(h) --> SHP-2(h){pY} (increase of phosphorylation) | BDNF(h) --> SHP-2(r){pY} (increase of phosphorylation) | BDNF(h) --> FRS2(r){pY} (increase of phosphorylation) | BDNF(h) --> Shc(r){pY} (increase of phosphorylation) | BDNF(h) --/ alpha-tubulin(r) (decrease of abundance) | NGF(m) + BDNF(h) <==> NGF(m):BDNF(h) (binding) | BDNF(h) --> Caspase-3-p20(r) (decrease of cleavage) | BDNF(h) --> BDNF-p28(h) + protein remnants (cleavage) | BDNF(h) --> BDNF-p14(h) + protein remnants (cleavage) | BDNF(h) + NDP-Gly --> BDNF(h){gly} + NMP (glycosylation) | BDNF(h) --> trkB(m.s.){pY} (increase of phosphorylation) | BDNF(h) --> FOXO3a(r){pT32}{pS253} (increase of phosphorylation) | BDNF(h) --> CREB1(r){pS133} (increase of phosphorylation) | BDNF(h) --> Elk-1(r){pS} (increase of phosphorylation) | BDNF(h) --> Raf-1(r){pS} (increase of phosphorylation) | BDNF(h) --> MEK(r){pS} (increase of phosphorylation) | BDNF(h) --> AKT-1(r){pS473} (increase of phosphorylation) | BDNF(h) --> GSK3(m.s.){pS} (increase of phosphorylation) | BDNF(h) --> PLCgamma1(r){pY} (increase of phosphorylation) | BDNF(h) --> IRS-1(r){pY} (increase of phosphorylation) | BDNF(h) --> Shc-1(r){pY} (increase of phosphorylation) | BDNF(h) --> p38(r){p} (increase of phosphorylation) | BDNF(h) --> Arg3.1(r) (increase of abundance) | BDNF(h) --> Arc(r) (transactivation) | BDNF(h) --> NR2A(r){pY} (increase of phosphorylation) | BDNF(h) --> AKT-1(r){pT308} (increase of phosphorylation) | BDNF(h) --> RSK(r){pT} (increase of phosphorylation) | BDNF(h) --> ERK5(r){p} (increase of phosphorylation) | BDNF(h) --> LKB1(m.s.){pS} (increase of phosphorylation) | BDNF(h) --> MSK1(r){pS} (increase of phosphorylation) | BDNF(h) --> CREB1(m){pS133} (increase of phosphorylation) | BDNF(h) --> ERK1(m){p} (increase of phosphorylation) | BDNF(h) --> ERK2(m){p} (increase of phosphorylation) | BDNF(h) --> RSK(m){pT} (increase of phosphorylation) | BDNF(h) --> Fos(m) (transactivation) | BDNF(h) --> Dusp1(m) (transactivation) | BDNF(h) --> NR4A2(m) (transactivation) | BDNF(h) --> DOK5(m.s.){pY} (increase of phosphorylation) | BDNF(h) --> ERK1(h){p} (increase of phosphorylation) | BDNF(h) --> ERK2(h){p} (increase of phosphorylation) | BDNF(h) --> ARMS(r){pY} (increase of phosphorylation) | BDNF(h) --> PLCgamma(r){pY} (increase of phosphorylation) | BDNF(h) --> GRIN2C(m) (transactivation) | BDNF(h) --> Grin1(m) (transactivation) | BDNF(h) --> NR1(m):NR2C(m) (increase of binding) | BDNF(h) --> Kv1.3(r){pY} (increase of phosphorylation) | BDNF(h) --> MSK1(m){pS375} (increase of phosphorylation) | BDNF(h) --> ERK1(r){pT203}{pY205} (increase of phosphorylation) | BDNF(h) --> ERK2(r){pT183}{pY185} (increase of phosphorylation) | BDNF(h) --> IRS-1(r):p85(r) (increase of binding) | BDNF(h) --> MSK1(r){p} (increase of phosphorylation) | BDNF(h) --> MEK(r){p} (increase of phosphorylation) | BDNF(h) --> SHP-2(r):p85(r) (increase of binding) | BDNF(h) --> SHP-2(h):p85(h) (increase of binding) | BDNF(h) --> SPP1(h) (transactivation) | BDNF(h) --> BMP2(h) (transactivation) | BDNF(h) --> Raf-1(h){pS338} (increase of phosphorylation) | BDNF(h) --> p53(r) (increase of abundance) | BDNF(h) --> ERK1(m){pY} (increase of phosphorylation) | BDNF(h) --> FRS2alpha(m){pY} (increase of phosphorylation) | BDNF(h) --/ Bim(r) (inhibition; decrease of abundance) | BDNF(h) --> BDNF(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 121 | N-linked (GlcNAc...). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr11 |
Promoter: 27678052 - 27680052 | Agilent_014791 |
chr11 |
Promoter: 27699372 - 27701372 | Agilent_014791 |
chr11 |
Promoter: 27698346 - 27700346 | Agilent_014791 |
chr11 |
Promoter: 27677256 - 27679256 | Agilent_014791 |
chr11 |
Promoter: 27699372 - 27701372 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 27698346 - 27700346 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 27677256 - 27679256 | GSE27584 |
chr11 |
Promoter: 27679229 - 27681229 | GSE27584 |
chr11 |
Promoter: 27698346 - 27700346 | GSE27584 |
chr11 |
Promoter: 27699372 - 27701372 | GSE27584 |
chr11 |
Promoter: 27678052 - 27680052 | GSE27584 |
chr11 |
Promoter: 27678052 - 27680052 | Agilent_014791_44K |
chr11 |
Promoter: 27677256 - 27679256 | Agilent_014791_44K |
chr11 |
Promoter: 27678052 - 27680052 | Agilent_014791 |
chr11 |
Promoter: 27699372 - 27701372 | Agilent_014791 |
chr11 |
Promoter: 27698346 - 27700346 | Agilent_014791 |
chr11 |
Promoter: 27678052 - 27680052 | PMID:16367923 |
chr11 |
Promoter: 27699372 - 27701372 | PMID:16367923 |
chr11 |
Promoter: 27698346 - 27700346 | PMID:16367923 |
chr11 |
Promoter: 27679229 - 27681229 | PMID:16367923 |
chr11 |
Promoter: 27677256 - 27679256 | PMID:16367923 |
chr11 |
Promoter: 27636749 - 27638749 | PMID:16367923 |