Entrez Gene

Basic Information
Gene ID	5605
Name	MAP2K2
Synonymous	MAPKK2\|MEK2\|MKK2\|PRKMK2;mitogen-activated protein kinase kinase 2;MAP2K2;mitogen-activated protein kinase kinase 2
Definition	ERK activator kinase 2\|MAP kinase kinase 2\|MAPK/ERK kinase 2\|dual specificity mitogen-activated protein kinase kinase 2\|mitogen-activated protein kinase kinase 2, p45
Position	19p13.3
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
A-Raf(h) + MEK2(h) <==> A-Raf(h):MEK2(h) (binding)
KSR(h) + MEK2(h) <==> KSR(h):MEK2(h) (binding)
Raf-1(h) + MEK2(h) <==> Raf-1(h):MEK2(h) (binding)
MEK2(h) + ATP --> MEK2(h){p} + ADP (phosphorylation)
MEK2(h) + ATP --> MEK2(h){pS} + ADP (phosphorylation)
MAP2K2(h) --> MEK2(h) (expression).
ERK1(h) + ATP --MEK2(h)--> ERK1(h){p} + ADP (phosphorylation)
ERK2(r) + MEK2(h) <==> ERK2(r):MEK2(h) (binding)
ERK1(h) + MEK2(h) <==> ERK1(h):MEK2(h) (binding)
ERK2(r) + MEK2(h) <==> ERK2(r):MEK2(h) (binding)
MAP2K2(h) --> MEK2(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
23	Phosphoserine.		Swiss-Prot 53.0
222	Phosphoserine (by RAF) (By similarity).		Swiss-Prot 53.0
226	Phosphoserine.		Swiss-Prot 53.0
394	Phosphothreonine.		Swiss-Prot 53.0
396	Phosphothreonine.		Swiss-Prot 53.0
394	Phosphothreonine	15302935;17081983	Phospho.ELM 6.0
226	Phosphoserine (MAP3K8;PDK-1)	15175348;15466476	Phospho.ELM 6.0
216	Phosphoserine	12506122	Phospho.ELM 6.0
222	Phosphoserine (MAP3K8)	15466476	Phospho.ELM 6.0
23	Phosphoserine	17081983	Phospho.ELM 6.0

Transcription Factors [Top]