| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 5605 |
Name | MAP2K2 |
Synonym | MAPKK2|MEK2|MKK2|PRKMK2;mitogen-activated protein kinase kinase 2;MAP2K2;mitogen-activated protein kinase kinase 2 |
Definition | ERK activator kinase 2|MAP kinase kinase 2|MAPK/ERK kinase 2|dual specificity mitogen-activated protein kinase kinase 2|mitogen-activated protein kinase kinase 2, p45 |
Position | 19p13.3 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | il-2 receptor beta chain in t cell activation;PID BioCarta;100129 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | role of erbb2 in signal transduction and oncology;PID BioCarta;100147 |
Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | sprouty regulation of tyrosine kinase signals;PID BioCarta;100029 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | regulation of splicing through sam68;PID BioCarta;100036 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | erk1/erk2 mapk signaling pathway;PID BioCarta;100170 |
Pathway | Bladder cancer;KEGG PATHWAY;hsa05219 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | mcalpain and friends in cell motility;PID BioCarta;100111 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade;PANTHER;P00032 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | human cytomegalovirus and map kinase pathways;PID BioCarta;100149 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | CXCR3-mediated signaling events;PID Curated;200150 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Downstream signaling in naive CD8+ T cells;PID Curated;200184 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | role of beta-arrestins in the activation and targeting of map kinases;PID BioCarta;100229 |
Pathway | phospholipids as signalling intermediaries;PID BioCarta;100183 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Thyroid cancer;KEGG PATHWAY;hsa05216 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | ceramide signaling pathway;PID BioCarta;100206 |
Pathway | influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054 |
Pathway | melanocyte development and pigmentation pathway;PID BioCarta;100108 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | anthrax toxin mechanism of action;PID BioCarta;100242 |
Pathway | trefoil factors initiate mucosal healing;PID BioCarta;100018 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Nongenotropic Androgen signaling;PID Curated;200145 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | ERK2 activation;PID Reactome;500086 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Prion diseases;KEGG PATHWAY;hsa05020 |
Pathway | role of mal in rho-mediated activation of srf;PID BioCarta;100114 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway;PID BioCarta;100210 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | RAF phosphorylates MEK;PID Reactome;500083 |
Pathway | Toll receptor signaling pathway;PANTHER;P00054 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | role of erk5 in neuronal survival pathway;PID BioCarta;100171 |
Pathway | Dorso-ventral axis formation;KEGG PATHWAY;hsa04320 |
Pathway | roles of beta arrestin dependent recruitment of src kinases in gpcr signaling;PID BioCarta;100230 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | links between pyk2 and map kinases;PID BioCarta;100057 |
Pathway | Cellular roles of Anthrax toxin;PID Curated;200179 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Signal transduction by L1;PID Reactome;500100 |
Pathway | fmlp induced chemokine gene expression in hmc-1 cells;PID BioCarta;100162 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | mTOR signaling pathway;PID Curated;200080 |
Pathway | fc epsilon receptor i signaling in mast cells;PID BioCarta;100165 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | MAP kinase cascade;BioCyc;PWY66-14 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | cadmium induces dna synthesis and proliferation in macrophages;PID BioCarta;100209 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
Disease | Cardiofaciocutaneous syndrome;OMIM |
External Links | |
Links to Entrez Gene | 5605 |
Links to all GeneRIF Items | 5605 |
Links to iHOP | 5605 |
Sequence Information | |
Nucleotide Sequence | >5605 : length: 1203 atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccctaccatcgccgag ggcccatcccctaccagcgagggcgcctccgaggcaaacctggtggacctgcagaagaag ctggaggagctggaacttgacgagcagcagaagaagcggctggaagcctttctcacccag aaagccaaggtcggcgaactcaaagacgatgacttcgaaaggatctcagagctgggcgcg ggcaacggcggggtggtcaccaaagtccagcacagaccctcgggcctcatcatggccagg aagctgatccaccttgagatcaagccggccatccggaaccagatcatccgcgagctgcag gtcctgcacgaatgcaactcgccgtacatcgtgggcttctacggggccttctacagtgac ggggagatcagcatttgcatggaacacatggacggcggctccctggaccaggtgctgaaa gaggccaagaggattcccgaggagatcctggggaaagtcagcatcgcggttctccggggc ttggcgtacctccgagagaagcaccagatcatgcaccgagatgtgaagccctccaacatc ctcgtgaactctagaggggagatcaagctgtgtgacttcggggtgagcggccagctcatc gactccatggccaactccttcgtgggcacgcgctcctacatggctccggagcggttgcag ggcacacattactcggtgcagtcggacatctggagcatgggcctgtccctggtggagctg gccgtcggaaggtaccccatccccccgcccgacgccaaagagctggaggccatctttggc cggcccgtggtcgacggggaagaaggagagcctcacagcatctcgcctcggccgaggccc cccgggcgccccgtcagcggtcacgggatggatagccggcctgccatggccatctttgaa ctcctggactatattgtgaacgagccacctcctaagctgcccaacggtgtgttcaccccc gacttccaggagtttgtcaataaatgcctcatcaagaacccagcggagcgggcggacctg aagatgctcacaaaccacaccttcatcaagcggtccgaggtggaagaagtggattttgcc ggctggttgtgtaaaaccctgcggctgaaccagcccggcacacccacgcgcaccgccgtg tga |
Protein Sequence | >5605 : length: 400 MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQ KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQ GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL KMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV |