| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4915 |
Name | NTRK2 |
Synonymous | GP145-TrkB|TRKB|trk-B;neurotrophic tyrosine kinase, receptor, type 2;NTRK2;neurotrophic tyrosine kinase, receptor, type 2 |
Definition | BDNF-tropomyosine receptor kinase B|BDNF/NT-3 growth factors receptor|trkB tyrosine kinase|tyrosine kinase receptor B |
Position | 9q22.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | trkB(h) + BDNF(h) <==> trkB(h):BDNF(h) (binding) | trkB(h) + BDNF(r) <==> trkB(h):BDNF(r) (binding) | trkB(h) + ubiquitin(h) --> trkB(h){ub} (ubiquitination) | trkB(h) + ATP --> trkB(h){pY} + ADP (phosphorylation) | trkB(h) --> BMP2(h) (transactivation) | trkB(h) --> SPP1(h) (transactivation) | trkB(h) --> Raf-1(h){pS338} (increase of phosphorylation) | trkB(h) + Fyn(m.s.) <==> trkB(h):Fyn(m.s.) (binding) | NTRK2(h) --> trkB(h) (expression). | trkB(h) + ATP --> trkB(h){pY} + ADP (phosphorylation; automodification) | trkB(h) + DOK5(m.s.) <==> trkB(h):DOK5(m.s.) (binding) | NTRK2(h) --> trkB(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 67 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 95 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 121 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 178 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 205 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 241 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 254 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 280 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 325 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 338 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 412 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 516 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 702 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 706 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 707 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 817 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr9 |
Promoter: 86472946 - 86474946 | Agilent_014791 |
chr9 |
Promoter: 86471786 - 86473786 | Agilent_014791 |
chr9 |
Promoter: 86472946 - 86474946 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 86471786 - 86473786 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 86471786 - 86473786 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 86471786 - 86473786 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 86471786 - 86473786 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 86471786 - 86473786 | GSE27584 |
chr9 |
Promoter: 86471786 - 86473786 | GSE27584 |
chr9 |
Promoter: 86471786 - 86473786 | GSE27584 |
chr9 |
Promoter: 86471786 - 86473786 | GSE27584 |
chr9 |
Promoter: 86472946 - 86474946 | GSE27584 |
chr9 |
Promoter: 86472946 - 86474946 | Agilent_014791_44K |
chr9 |
Promoter: 86471786 - 86473786 | Agilent_014791_44K |
chr9 |
Promoter: 86471786 - 86473786 | Agilent_014791_44K |
chr9 |
Promoter: 86471786 - 86473786 | Agilent_014791_44K |
chr9 |
Promoter: 86471786 - 86473786 | Agilent_014791_44K |