| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4914 |
Name | NTRK1 |
Synonymous | MTC|TRK|TRK1|TRKA|Trk-A|p140-TrkA;neurotrophic tyrosine kinase, receptor, type 1;NTRK1;neurotrophic tyrosine kinase, receptor, type 1 |
Definition | Oncogene TRK|TRK1-transforming tyrosine kinase protein|high affinity nerve growth factor receptor|tyrosine kinase receptor A |
Position | 1q21-q22 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | paxillin(h) + trkA(h) <==> paxillin(h):trkA(h) (binding) | trkA(h) + NTP --trkA(h)--> trkA(h){pY} + NDP (phosphorylation) | trkA(h) + NGF(m) <==> trkA(h):NGF(m) (binding) | trkA(h) + NT-3(h) <==> trkA(h):NT-3(h) (binding) | trkA(h) --> APP695(m.s.){pY682} (increase of phosphorylation) | trkA(h) + n ubiquitin(r) --> trkA(h){ub(1)}n (ubiquitination) | trkA(h) + NGF(h) <==> trkA(h):NGF(h) (binding) | 2 trkA(h) <==> (trkA(h))2 (binding) | trkA(h) + ATP --> trkA(h){pY} + ADP (phosphorylation; automodification) | trkA(h) + APPL(h) <==> trkA(h):APPL(h) (binding) | RanBPM(h) + trkA(h) <==> RanBPM(h):trkA(h) (binding) | trkA(h) + p53(h) <==> trkA(h):p53(h) (binding) | GRIT(h) + trkA(h) <==> GRIT(h):trkA(h) (binding) | CHC(r) + trkA(h) <==> CHC(r):trkA(h) (binding) | trkA(h) + caveolin-1(r) <==> trkA(h):caveolin-1(r) (binding) | trkA(h) + CTGF(h) <==> trkA(h):CTGF(h) (binding) | trkA(h) + Grb-2(h) <==> trkA(h):Grb-2(h) (binding) | NTRK1(h) --> trkA(h) (expression). | trkA(h){p} --SHP-1(m.s.)--> trkA(h) + p (dephosphorylation) | MATH1(m.s.) --> trkA(h) (increase of abundance) | trkA(h) + NTP --trkA(h)--> trkA(h){pY} + NDP (phosphorylation) | FRS2(h) + ATP --trkA(h)--> FRS2(h){p} + ADP (phosphorylation) | TrkA-I(h) + APPL(r) <==> TrkA-I(h):APPL(r) (binding) | RanBPM(m) + TrkA-I(h) <==> RanBPM(m):TrkA-I(h) (binding) | Abl(m) + TrkA-I(h) <==> Abl(m):TrkA-I(h) (binding) | SH2-B(m) + TrkA-I(h) <==> SH2-B(m):TrkA-I(h) (binding) | PLCgamma(m) + TrkA-I(h) <==> PLCgamma(m):TrkA-I(h) (binding) | TrkA-I(h) + ATP --> TrkA-I(h){pY490} + ADP (phosphorylation; automodification) | TrkA-I(h) + 3 ATP --> TrkA-I(h){pY490}{pY674}{pY675} + 3 ADP (phosphorylation) | TrkA-I(h) + ATP --Src(m.s.){p}--> TrkA-I(h){pY490} + ADP (phosphorylation) | TrkA-I(h) + ATP --> TrkA-I(h){pY785} + ADP (phosphorylation; automodification) | TrkA-I(h) + PLCgamma1(r) <==> TrkA-I(h):PLCgamma1(r) (binding) | NTRK1(h) --> TrkA-I(h) (expression). | TrkA-I(h){p} --SHP-1(m.s.)--> TrkA-I(h) + p (dephosphorylation) | TrkA-I(h){pY674}{pY675} --> TrkA-I(h) + 2 p (dephosphorylation) | NTRK1(h) --> trkA-II(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 67 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 95 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 121 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 188 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 202 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 253 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 262 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 281 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 318 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 323 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 338 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 358 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 401 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 496 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 676 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 680 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 681 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 791 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 496 | Phosphotyrosine (TRKA) | 11159935;8155326 | Phospho.ELM 6.0 | 791 | Phosphotyrosine (TRKA) | 11159935;8155326 | Phospho.ELM 6.0 | 676 | Phosphotyrosine (TRKA) | 11159935 | Phospho.ELM 6.0 | 680 | Phosphotyrosine (TRKA) | 11159935 | Phospho.ELM 6.0 | 681 | Phosphotyrosine (TRKA) | 11159935 | Phospho.ELM 6.0 | 757 | Phosphotyrosine | 16319926 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr1 |
Promoter: 155050666 - 155052666 | Agilent_014791 |
chr1 |
Promoter: 155050666 - 155052666 | GoldenGate_Methylation_Cancer_Panel_I |
chr1 |
Promoter: 155050666 - 155052666 | GSE27584 |
chr1 |
Promoter: 155095795 - 155097795 | GSE27584 |
chr1 |
Promoter: 155095795 - 155097795 | GSE27584 |
chr1 |
Promoter: 155050666 - 155052666 | E-GEOD-20553 |
chr1 |
Promoter: 155095795 - 155097795 | E-GEOD-20553 |
chr1 |
Promoter: 155095795 - 155097795 | E-GEOD-20553 |