| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4914 |
Name | NTRK1 |
Synonym | MTC|TRK|TRK1|TRKA|Trk-A|p140-TrkA;neurotrophic tyrosine kinase, receptor, type 1;NTRK1;neurotrophic tyrosine kinase, receptor, type 1 |
Definition | Oncogene TRK|TRK1-transforming tyrosine kinase protein|high affinity nerve growth factor receptor|tyrosine kinase receptor A |
Position | 1q21-q22 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | ARMS-mediated activation;PID Reactome;500631 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | Retrograde neurotrophin signalling;PID Reactome;500645 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Signalling to RAS;PID Reactome;500626 |
Pathway | Signalling to STAT3;PID Reactome;500643 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | PLC-gamma1 signalling;PID Reactome;500632 |
Pathway | Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128 |
Pathway | Signalling to ERKs;PID Reactome;500625 |
Pathway | NGF signalling via TRKA from the plasma membrane;PID Reactome;500621 |
Pathway | PI3K/AKT signalling;PID Reactome;500639 |
Pathway | TRKA activation by NGF;PID Reactome;500623 |
Pathway | role of erk5 in neuronal survival pathway;PID BioCarta;100171 |
Pathway | trka receptor signaling pathway;PID BioCarta;100011 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Signalling to p38 via RIT and RIN;PID Reactome;500628 |
Pathway | Thyroid cancer;KEGG PATHWAY;hsa05216 |
Disease | Cancers of the nervous system;KEGG DISEASE |
Disease | Thyroid cancer;KEGG DISEASE;H00032 |
Disease | Cancers;KEGG DISEASE |
Disease | Insensitivity to pain, congenital, with anhidrosis;OMIM |
Disease | Medullary thyroid carcinoma, familial;OMIM |
Disease | Neuroblastoma;KEGG DISEASE;H00043 |
Disease | Cancers of endocrine organs;KEGG DISEASE |
Disease | CANCER;GAD |
Disease | neuroblastoma;GAD |
External Links | |
Links to Entrez Gene | 4914 |
Links to all GeneRIF Items | 4914 |
Links to iHOP | 4914 |
Sequence Information | |
Nucleotide Sequence | >4914 : length: 2283 atgaaggaggccgccctcatctgcctggcaccctctgtacccccgatcttgacggtgaag tcctgggacaccatgcagttgcgggctgctagatctcggtgcacaaacttgttggcagca agctacatcgagaaccagcagcatctgcagcatctggagctccgtgatctgaggggcctg ggggagctgagaaacctcaccatcgtgaagagtggtctccgtttcgtggcgccagatgcc ttccatttcactcctcggctcagtcgcctgaatctctccttcaacgctctggagtctctc tcctggaaaactgtgcagggcctctccttacaggaactggtcctgtcggggaaccctctg cactgttcttgtgccctgcgctggctacagcgctgggaggaggagggactgggcggagtg cctgaacagaagctgcagtgtcatgggcaagggcccctggcccacatgcccaatgccagc tgtggtgtgcccacgctgaaggtccaggtgcccaatgcctcggtggatgtgggggacgac gtgctgctgcggtgccaggtggaggggcggggcctggagcaggccggctggatcctcaca gagctggagcagtcagccacggtgatgaaatctgggggtctgccatccctggggctgacc ctggccaatgtcaccagtgacctcaacaggaagaacgtgacgtgctgggcagagaacgat gtgggccgggcagaggtctctgttcaggtcaacgtctccttcccggccagtgtgcagctg cacacggcggtggagatgcaccactggtgcatccccttctctgtggatgggcagccggca ccgtctctgcgctggctcttcaatggctccgtgctcaatgagaccagcttcatcttcact gagttcctggagccggcagccaatgagaccgtgcggcacgggtgtctgcgcctcaaccag cccacccacgtcaacaacggcaactacacgctgctggctgccaaccccttcggccaggcc tccgcctccatcatggctgccttcatggacaaccctttcgagttcaaccccgaggacccc atccctgacactaacagcacatctggagacccggtggagaagaaggacgaaacacctttt ggggtctcggtggctgtgggcctggccgtctttgcctgcctcttcctttctacgctgctc cttgtgctcaacaaatgtggacggagaaacaagtttgggatcaaccgcccggctgtgctg gctccagaggatgggctggccatgtccctgcatttcatgacattgggtggcagctccctg tcccccaccgagggcaaaggctctgggctccaaggccacatcatcgagaacccacaatac ttcagtgatgcctgtgttcaccacatcaagcgccgggacatcgtgctcaagtgggagctg ggggagggcgcctttgggaaggtcttccttgctgagtgccacaacctcctgcctgagcag gacaagatgctggtggctgtcaaggcactgaaggaggcgtccgagagtgctcggcaggac ttccagcgtgaggctgagctgctcaccatgctgcagcaccagcacatcgtgcgcttcttc ggcgtctgcaccgagggccgccccctgctcatggtctttgagtatatgcggcacggggac ctcaaccgcttcctccgatcccatggacctgatgccaagctgctggctggtggggaggat gtggctccaggccccctgggtctggggcagctgctggccgtggctagccaggtcgctgcg gggatggtgtacctggcgggtctgcattttgtgcaccgggacctggccacacgcaactgt ctagtgggccagggactggtggtcaagattggtgattttggcatgagcagggatatctac agcaccgactattaccgtgtgggaggccgcaccatgctgcccattcgctggatgccgccc gagagcatcctgtaccgtaagttcaccaccgagagcgacgtgtggagcttcggcgtggtg ctctgggagatcttcacctacggcaagcagccctggtaccagctctccaacacggaggca atcgactgcatcacgcagggacgtgagttggagcggccacgtgcctgcccaccagaggtc tacgccatcatgcggggctgctggcagcgggagccccagcaacgccacagcatcaaggat gtgcacgcccggctgcaagccctggcccaggcacctcctgtctacctggatgtcctgggc tag |
Protein Sequence | >4914 : length: 760 MKEAALICLAPSVPPILTVKSWDTMQLRAARSRCTNLLAASYIENQQHLQHLELRDLRGL GELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPL HCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDD VLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAEND VGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFT EFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDP IPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVL APEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWEL GEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFF GVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAA GMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPP ESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEV YAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG |