Entrez Gene

Basic Information
Gene ID	4751
Name	NEK2
Synonymous	HsPK21\|NEK2A\|NLK1;NIMA (never in mitosis gene a)-related kinase 2;NEK2;NIMA (never in mitosis gene a)-related kinase 2
Definition	nimA-like protein kinase 1\|nimA-related protein kinase 2\|serine/threonine-protein kinase Nek2
Position	1q32.2-q41
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
Nek2A(h) + n ubiquitin(v.s.) --cyclosome(x):Cdc20(x)--> Nek2A(h){ub(n)} (ubiquitination)
PP1-gamma1(h) + Nek2A(h) <==> PP1-gamma1(h):Nek2A(h) (binding)
Nek2A(h) + ATP --> Nek2A(h){p} + ADP (phosphorylation)
Nek2A(h) + C-Nap1(h) + PP1-alpha(rb) <==> Nek2A(h):C-Nap1(h):PP1-alpha(rb) (binding)
Nek2A(h) + PP1C(rb) + IPP-2(rb) <==> Nek2A(h):PP1C(rb):IPP-2(rb) (binding)
Hec1(h) + Nek2A(h) <==> Hec1(h):Nek2A(h) (binding)
2 Nek2A(h) <==> (Nek2A(h))2 (binding)
Nek2B(h) + Nek2A(h) <==> Nek2B(h):Nek2A(h) (binding)
Nek2A(h) + beta-catenin(m) <==> Nek2A(h):beta-catenin(m) (binding)
Nek2A(h) + ATP --> Nek2A(h){p} + ADP (phosphorylation; automodification)
NEK2(h) --> Nek2A(h) (expression).
Hec1(h) + ATP --Nek2A(h)--> Hec1(h){pS165} + ADP (phosphorylation)
beta-catenin(m.s.) + ATP --Nek2A(h)--> beta-catenin(m.s.){p} + ADP (phosphorylation)
beta-catenin(m) + ATP --Nek2A(h)--> beta-catenin(m){p} + ADP (phosphorylation)
Nek2B(h) + Nek2A(h) <==> Nek2B(h):Nek2A(h) (binding)
2 Nek2B(h) <==> (Nek2B(h))2 (binding)
NEK2(h) --> Nek2B(h) (expression).
Nek2(h) + C-Nap1(h) <==> Nek2(h):C-Nap1(h) (binding)
Nek2(h) + Mad1(h) <==> Nek2(h):Mad1(h) (binding)
Cdc27(h) + Nek2(h) <==> Cdc27(h):Nek2(h) (binding)
Nek2(h) + beta-catenin(x) <==> Nek2(h):beta-catenin(x) (binding)
Nek2(h) + beta-catenin(h) <==> Nek2(h):beta-catenin(h) (binding)
NEK2(h) --> Nek2(h) (expression).
C-Nap1(h) + ATP --Nek2(h)--> C-Nap1(h){p} + ADP (phosphorylation)

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
175	Phosphothreonine (by autocatalysis) (Bysimilarity).		Swiss-Prot 53.0

Transcription Factors [Top]