| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4286 |
Name | MITF |
Synonymous | MI|WS2|WS2A|bHLHe32;microphthalmia-associated transcription factor;MITF;microphthalmia-associated transcription factor |
Definition | class E basic helix-loop-helix protein 32 |
Position | 3p14.2-p14.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | TFEA(h) + MITF(h) <==> TFEA(h):MITF(h) (binding). | tfeb-isoform1(h) + MITF(h) <==> tfeb-isoform1(h):MITF(h) (binding). | MITF(h) + tcfec(r) <==> MITF(h):tcfec(r) (binding). | MITF(h) + MITF(m) <==> MITF(h):MITF(m) (binding). | MITF(h) + ATP --RSK1(h)--> MITF(h){pS409} + ADP (phosphorylation) | MITF(h) + ATP --ERK2(h)--> MITF(h){pS73} + ADP (phosphorylation) | MITF(h) + MITF(h) <==> MITF(h):MITF(h) (binding). | MITF(h) --> BCL2(h) (DNA binding; transactivation). | MITF(h) --> SILV(h) (transactivation) | MITF(h) --> CTSK(h) (DNA binding; transactivation). | MITF(h) --> DCT(h) (DNA binding; transactivation). | MITF(h) --> MLANA(h) (DNA binding; transactivation). | MITF(h) --> Fos(m) (DNA binding; transactivation). | MITF(h) --> MC1R(h) (DNA binding). | MITF(h) --> TYR(h) (transactivation) | MITF(h) --> TYRP1(h) (DNA binding). | MITF(h) --> GPR143(h) (DNA binding). | MITF(h) + ATP --> ADP + MITF(h){pS73} (phosphorylation) | MITF(h) --> MET(h) (DNA binding). | MITF(h) --> BIRC7(h) (DNA binding). | MITF(h) --> VMD2(h) (DNA binding; transactivation). | MITF(h) --> KIT(h) (transactivation) | ERK2(r) + MITF(h) <==> ERK2(r):MITF(h) (binding) | ERK2(r) + MITF(h) <==> ERK2(r):MITF(h) (binding) | MITF(h) + ERK2(r){p} <==> MITF(h):ERK2(r){p} (binding) | MITF(h) + ATP --> MITF(h){p} + ADP (phosphorylation) | MITF(h) --> DCT(h) (transactivation) | LEF1-isoform3(h) + MITF(h) <==> LEF1-isoform3(h):MITF(h) (binding) | MITF(h) --> SLC45A2(h) (transactivation) | MITF(h) --> PMEL17(h) (increase of abundance) | MITF(h) --> MLANA(h) (increase of abundance) | MITF(h) --> TRPM1(h) (transactivation) | MITF(h) --> MLANA(h) (transactivation) | MITF(h) --> c-Met(h) (increase of abundance) | MITF(h) --> MITF(h) (expression). | TGFbeta1(m.s.) --/ MITF(h) (decrease of abundance) | UV-B --> MITF(h) (increase of abundance) | Pax-3(m.s.) --> MITF(h) (increase of abundance) | opiomelanocortin(m.s.) --> MITF(h) (increase of abundance) | ET-1(m.s.) --> MITF(h) (increase of abundance) | alpha-MSH(m.s.) --> MITF(h) (increase of abundance) | HGF(m.s.) --/ MITF(h) (decrease of abundance) | MITF(m) --> MITF(h) (increase of abundance) | LPS --> MITF(h) (increase of abundance) | MITF(h) --> MITF_01(h) (expression). | hsa-miR-124a --/ MITF_01(h) (predicted) | ms-miR-340 --/ MITF_01(h) (increase of mRNA decay). | MITF(h) --> MITF_02(h) (expression). | hsa-miR-124a --/ MITF_02(h) (predicted) | ms-miR-340 --/ MITF_02(h) (increase of mRNA decay). | MITF(h) --> MITF_03(h) (expression). | hsa-miR-124a --/ MITF_03(h) (predicted) | ms-miR-340 --/ MITF_03(h) (increase of mRNA decay). | MITF(h) --> MITF_04(h) (expression). | hsa-miR-124a --/ MITF_04(h) (predicted) | ms-miR-340 --/ MITF_04(h) (increase of mRNA decay). | MITF(h) --> MITF_05(h) (expression). | hsa-miR-124a --/ MITF_05(h) (predicted) | ms-miR-340 --/ MITF_05(h) (increase of mRNA decay). | MITF(h) --> MITF_06(h) (expression). | hsa-miR-124a --/ MITF_06(h) (predicted) | ms-miR-340 --/ MITF_06(h) (increase of mRNA decay). | MITF-M1(h) --> TYR(h) (DNA binding; transactivation). | MITF-M1(h) --> TYRP1(h) (DNA binding; transactivation). | MITF-M1(h) + sumo1(h) --> MITF-M1(h){sumo} (sumoylation) | MITF-M1(h) + tfeb(h) <==> MITF-M1(h):tfeb(h) (binding) | MITF-M1(h) + sumo1(h) --PIAS3(m.s.)--> MITF-M1(h){sumoK182}{sumoK316} (sumoylation) | MITF-M1(h) --> TRPM1(h) (transactivation) | MITF-M1(h) --> SILV(h) (transactivation) | MITF-M1(h) --> CTSK(h) (transactivation) | MITF-M1(h) --> TYR(h) (transactivation) | MITF-M1(h) + TFEA(h) <==> MITF-M1(h):TFEA(h) (binding) | MITF(h) --> MITF-M1(h) (expression). | MITF(h) --> MITF-M2(h) (expression). | MITF(h) --> MITF-H1(h) (expression). | MITF(h) --> MITF-H2(h) (expression). | MITF(h) --> MITF-C1(h) (expression). | MITF(h) --> MITF-C2(h) (expression). | MITF(h) --> MITF-B1(h) (expression). | MITF(h) --> MITF-B2(h) (expression). | MITF(h) --> MITF-A1(h) (expression). | MITF(h) --> MITF-A2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 405 | Phosphoserine (by GSK3). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr3 |
Promoter: 69869823 - 69871823 | Agilent_014791 |
chr3 |
Promoter: 69869823 - 69871823 | GSE27584 |
chr3 |
Promoter: 69996632 - 69998632 | GSE27584 |
chr3 |
Promoter: 69869823 - 69871823 | Agilent_014791_44K |