| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3976 |
Name | LIF |
Synonymous | CDF|DIA|HILDA;leukemia inhibitory factor (cholinergic differentiation factor);LIF;leukemia inhibitory factor (cholinergic differentiation factor) |
Definition | D factor|MLPLI|cholinergic differentiation factor|differentiation inhibitory activity|differentiation stimulating factor|differentiation-inducing factor|differentiation-stimulating factor|hepatocyte-stimulating factor III|human interleukin in DA cells|leu |
Position | 22q12.2 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | LIF(h) --> LIFR(h){p} (increase of phosphorylation) | LIF(h) --> star(v.s.) (decrease of abundance) | LIF(h) --> STAT3(m.s.){pY705} (increase of phosphorylation) | LIF(h) --/ gp130(r) (decrease of abundance) | LIF(h) --> STAT3(m){pY705} (increase of phosphorylation) | LIF(h) --> STAT3(h){pY} (increase of phosphorylation) | LIF(h) --> LIF(h) (expression). | TNF-alpha(m.s.) --> LIF(h) (increase of secretion) | IL-1alpha(m.s.) --> LIF(h) (increase of secretion) | IL-6(m.s.) --> LIF(h) (increase of secretion) | SCF(m.s.) --> LIF(h) (increase of secretion) | leptin(h) --> LIF(h) (increase of secretion) | IL-13(h) --> LIF(h) (decrease of secretion) | IL-1beta(h) --> LIF(h) (increase of secretion) | LIF(h) --> gp130-isoform1(h){pY} (increase of phosphorylation) | LIF(h) --> LIFR(h){pY} (increase of phosphorylation) | LIF(h) --> STAT3(h){pY705} (increase of phosphorylation) | LIF(h) --> STAT3(h){aceK685} (increase of acetylation) | LIF(h) --> STAT3(h){pY705}{pS727} (increase of phosphorylation) | LIF(h) --> LIF(h) (expression). | LIF(h) --> LIF(h) (expression). | hsa-miR-125a --/ LIF(h) (predicted) | hsa-miR-125b --/ LIF(h) (predicted) |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 31 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 56 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 85 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 95 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 118 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 138 | N-linked (GlcNAc...). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr22 |
Promoter: 28972248 - 28974248 | GoldenGate_Methylation_Cancer_Panel_I |
chr22 |
Promoter: 28972248 - 28974248 | GSE27584 |
chr22 |
Promoter: 28972248 - 28974248 | Agilent_014791_44K |