| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3553 |
Name | IL1B |
Synonymous | IL-1|IL1-BETA|IL1F2;interleukin 1, beta;IL1B;interleukin 1, beta |
Definition | IL-1 beta|catabolin|interleukin-1 beta|preinterleukin 1 beta|pro-interleukin-1-beta |
Position | 2q14 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | IL-1beta(h) --> Trx(r) (activation; translocation) | IL-1beta(h) --> PTGS2(h) (transactivation) | IL-1beta(h) + IL-1RI(h) <==> IL-1beta(h):IL-1RI(h) (binding) | IL-1beta(h) + IL-1RII(m) + IL-1RAcP(m) <==> IL-1beta(h):IL-1RII(m):IL-1RAcP(m) (binding) | IL-1beta(h) --> S-SMase(m) (activation) | IL-1beta(h) --> N-SMase(r) (activation) | IL-1beta(h) --> A-SMase(r) (activation) | IL-1beta(h) + IL-1RI(h) + MyD88(h) + IRAK-4(h) + IRAK1(h) + TRAF6(h) <==> IL-1beta(h):IL-1RI(h):MyD88(h):IRAK-4(h):IRAK1(h):TRAF6(h) (binding) | IL-1beta(h) --> IL6(h) (transactivation) | IL-1beta(h) --/ IkappaB-alpha(h) (decrease of abundance) | IL-1beta(h) --> IKK-gamma(h):IRAK1(h) (increase of binding) | IL-1beta(h) --> IRAK1(h){pT209}{pT387}{p}n (increase of phosphorylation) | IL-1beta(h) --> IL-1RI(h):TRAF6(h):IRAK1(h) (increase of binding) | IL-1beta(h) --> TAK1(h):IRAK1(h) (increase of binding) | IL-1beta(h) --> TRAF6(h):TAK1(h) (increase of binding) | IL-1beta(h) --> TAB2(h):TRAF6(h) (increase of binding) | IL-1beta(h) --> TAK1(h){pT187} (increase of phosphorylation) | IL-1beta(h) --> IRAK1(h):TAB2(h) (increase of binding) | IL-1beta(h) --> RelA-p65(m) (increase of phosphorylation) | IL-1beta(h) --> RelA-p65(h) (increase of phosphorylation) | IL-1beta(h) --> p70S6K1-alpha2(h){pT389} (increase of phosphorylation) | IL-1beta(h) --> TRAF6(h){ub}n (increase of ubiquitination) | IL-1beta(h) --> CCL2(h) (transactivation) | IL-1beta(h) --> IL8(h) (transactivation) | IL-1beta(h) --> RSK1(r){pT359}{pS363}{pS380} (increase of phosphorylation) | IL-1beta(h) --> ERK1(r){p} (increase of phosphorylation) | IL-1beta(h) --> ERK2(r){p} (increase of phosphorylation) | IL-1beta(h) --/ IkappaB-beta(r) (decrease of abundance) | IL-1beta(h) --> SELE(h) (transactivation) | IL-1beta(h) --Caspase-1(h)--> IL-1beta-p20(h) + protein remnants (cleavage) | IL-1beta(h) --chymase(h)--> IL-1beta-p18(h) + protein remnants (cleavage) | IL-1beta(h) --> p38(h){p} (increase of phosphorylation) | IL-1beta(h) --> TNF-alpha(m) (increase of abundance) | IL-1beta(h) --> IL-6(m) (increase of secretion) | IL-1beta(h) --> GROalpha(m) (increase of abundance) | IL-1beta(h) --> Ptpn2(r) (transactivation) | IL-1beta(h) --> TC-PTPa(r) (increase of abundance) | IL-1beta(h) --> Actb(r) (transactivation) | IL-1beta(h) --> Srp14(r) (transactivation) | IL-1beta(h) --> VEGF-A(h) (increase of secretion) | IL-1beta(h) --> TGFB1(h) (transactivation) | IL-1beta(h) --> TGFB2(h) (transactivation) | IL-1beta(h) --> TGFbeta1(h) (increase of secretion) | IL-1beta(h) --> TGFbeta2(h) (increase of secretion) | IL-1beta(h) --> IL-11(h) (increase of secretion) | IL-1beta(h) --> IkappaBzeta(h) (increase of abundance) | IL-1beta(h) --> IL-8(h) (increase of secretion) | IL-1beta(h) --> DEFB4(h) (transactivation) | IL-1beta(h) --> TAK1(h):TRAF6(h):IKK-gamma(h) (increase of binding) | IL-1beta(h) --/ IRAK1(h) (decrease of abundance) | IL-1beta(h) --> IkappaB-alpha(h){ub{K48}(n)} (increase of ubiquitination) | IL-1beta(h) --> IRAK1(h){ub{K63}(n)} (increase of ubiquitination) | IL-1beta(h) --> TAB2(h):TAK1(h) (increase of binding) | IL-1beta(h) --> IKK-gamma(h):IRAK1(h){ub{K63}(n)} (increase of binding) | IL-1beta(h) --> IRAK1(h){ub{K63}(n)}:TAK1(h):TRAF6(h):IKK-gamma(h) (increase of binding) | IL-1beta(h) --> IKK-gamma(h):IRAK1(h){ub{K63}(n)} (increase of binding) | IL-1beta(h) --> IRAK1(h):IKK-alpha(h) (increase of binding) | IL-1beta(h) --> IRAK1(h):IKK-beta(h) (increase of binding) | IL-1beta(h) --> IKK-alpha(h){pS176}{pS180} (increase of phosphorylation) | IL-1beta(h) --> IKK-beta(h){pS177}{pS181} (increase of phosphorylation) | IL-1beta(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | IL-1beta(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | IL-1beta(h) --> TAB2(h):TRAF6(h){ub}n (increase of binding) | IL-1beta(h) --> TAB2(h):IRAK1(h){ub{K63}(n)} (increase of binding) | IL-1beta(h) --> TAK1(h):TAB1(h) (increase of binding) | IL-1beta(h) --> NF-kappaB1-isoform1(m){pS935} (increase of phosphorylation) | IL-1beta(h) --> CCL20(h) (transactivation) | IL-1beta(h) --/ IkappaB-alpha(m) (decrease of abundance) | IL-1beta(h) --> IkappaB-alpha(m.s.){p} (increase of phosphorylation) | IL-1beta(h) --> c-Jun(m.s.){p} (increase of phosphorylation) | IL-1beta(h) --> JNK(m){p} (increase of phosphorylation) | IL-1beta(h) --> TRAF6(m){ub(n)} (increase of ubiquitination) | IL-1beta(h) --> eotaxin-1(h) (increase of secretion) | IL-1beta(h) --> CCL11(h) (transactivation) | IL-1beta(h) --> TAB1(h):TAK1(h){pT187} (increase of binding) | IL-1beta(h) --> IKK-gamma(m){ub}n (increase of ubiquitination) | IL-17A(h) --> IL-1beta(h) (activation) | IL1B(h) --> IL-1beta(h) (expression). | NAC(h) --> IL-1beta(h) (increase of secretion) | IL-1beta(h) --Caspase-1(h)--> IL-1beta-p17(h) + protein remnants (processing) | IL-1beta(h) --Caspase-1(m)--> protein remnants (cleavage) | IL-1beta(h) --> P-selectin(m) (increase of abundance) | IL-1beta(h) --> LIF(h) (increase of secretion) | IL-1beta(h) --> IL-1beta-p17(h) + protein remnants (processing) | IL1B(h) --> IL-1beta(h) (expression). | P2RX7(h) --> IL-1beta(h) (increase of secretion) | Nod2(h) --> IL-1beta(h) (increase of secretion) | Caspase-4(h) --> IL-1beta(h) (increase of secretion) | IFNgamma(h) --> IL-1beta(h) (increase of secretion) | 3pRNA --> IL-1beta(h) (increase of secretion) | LPS(ECO) --> IL-1beta(h) (increase of secretion) | ASC(h) --> IL-1beta(h) (increase of secretion) | CIAS1(h) --> IL-1beta(h) (increase of secretion) | MyD88(h) --> IL-1beta(h) (increase of secretion) | Syk(h) --> IL-1beta(h) (increase of secretion) |
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Post Translational Modification [Top] | |||
There is no record for IL1B | |||
Methylation Profile [Top] | ||
There is no record for IL1B | ||