Entrez Gene

Basic Information
Gene ID	3280
Name	HES1
Synonymous	HES-1\|HHL\|HRY\|bHLHb39;hairy and enhancer of split 1, (Drosophila);HES1;hairy and enhancer of split 1, (Drosophila)
Definition	class B basic helix-loop-helix protein 39\|hairy homolog\|hairy-like protein\|transcription factor HES-1
Position	3q28-q29
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
HES-1(h) --/ MASH-1(h) (inhibition)
SIRT1(h) + HES-1(h) <==> SIRT1(h):HES-1(h) (binding)
HES-1(h) --> PTGDS(r) (DNA binding).
NICD1(h) --> HES-1(h) (activation)
NICD2(h) --> HES-1(h) (activation)
HES1(h) --> HES-1(h) (expression).
HES-1(h) + pRb(m.s.) <==> HES-1(h):pRb(m.s.) (binding)
AML3(m) + HES-1(h) <==> AML3(m):HES-1(h) (binding)
HES-1(h) + pRb(h) <==> HES-1(h):pRb(h) (binding)
HES-1(h) --/ PTGDS(h) (DNA binding; transrepression).
HES-1(h) --/ ASCL1(h) (DNA binding; transrepression).
HES-1(h) --/ REST(h) (DNA binding; transrepression).
HES-1(h) --> Hes1(r) (DNA binding).
HES-1(h) --> Rcor2(m) (DNA binding).
HES-1(h) --> GAA(h) (DNA binding; transactivation).
HES-1(h) --> GHR(h) (DNA binding).
HES1(h) --> HES-1(h) (expression).
EGF(m.s.) --/ HES-1(h) (decrease of abundance)
HES1(h) --> HES1(h) (expression).
hsa-miR-23a --/ HES1(h) (predicted)

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]

Transcription Factors [Top]