| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3280 |
Name | HES1 |
Synonymous | HES-1|HHL|HRY|bHLHb39;hairy and enhancer of split 1, (Drosophila);HES1;hairy and enhancer of split 1, (Drosophila) |
Definition | class B basic helix-loop-helix protein 39|hairy homolog|hairy-like protein|transcription factor HES-1 |
Position | 3q28-q29 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
in same component |
APITD1 | NCI_NATURE; |
in same component |
BLM | NCI_NATURE; |
in same component |
CREBBP | NCI_NATURE; |
in same component |
FAAP100 | NCI_NATURE; |
in same component |
FAAP24 | NCI_NATURE; |
in same component |
FANCA | NCI_NATURE; |
in same component |
FANCB | NCI_NATURE; |
in same component |
FANCC | NCI_NATURE; |
in same component |
FANCE | NCI_NATURE; |
in same component |
FANCF | NCI_NATURE; |
in same component |
FANCG | NCI_NATURE; |
in same component |
FANCL | NCI_NATURE; |
in same component |
FANCM | NCI_NATURE; |
in same component |
GATA1 | NCI_NATURE; |
in same component |
HES6 | NCI_NATURE; |
in same component |
JAK2 | NCI_NATURE; |
in same component |
MYB | NCI_NATURE; |
in same component |
PARP1 | NCI_NATURE; |
in same component |
PTF1A | NCI_NATURE; |
in same component |
RB1 | NCI_NATURE; |
in same component |
RBPJ | NCI_NATURE; |
in same component |
RMI1 | NCI_NATURE; |
in same component |
RUNX2 | NCI_NATURE; |
in same component |
TLE1 | NCI_NATURE; |
in same component |
TOP3A | NCI_NATURE; |
in same component |
UBE2T | NCI_NATURE; |
interacts with |
FANCA | BIOGRID; |
interacts with |
FANCC | BIOGRID; |
interacts with |
FANCE | BIOGRID; |
interacts with |
FANCE | HPRD; |
interacts with |
FANCF | BIOGRID; |
interacts with |
FANCF | HPRD; |
interacts with |
FANCG | BIOGRID; |
interacts with |
FANCL | BIOGRID; |
interacts with |
FANCL | HPRD; |
interacts with |
FOXG1 | HPRD; |
interacts with |
HDAC1 | BIOGRID; |
interacts with |
HES6 | HPRD; |
interacts with |
HEY2 | BIOGRID; |
interacts with |
HEY2 | HPRD; |
interacts with |
HMGB1 | HPRD; |
interacts with |
HSP90AA1 | BIOGRID; |
interacts with |
HSPA4 | BIOGRID; |
interacts with |
ID1 | HPRD; |
interacts with |
ID2 | HPRD; |
interacts with |
ID3 | HPRD; |
interacts with |
ID4 | HPRD; |
interacts with |
JAK2 | HPRD; |
interacts with |
PRKCA | HPRD; |
interacts with |
RUNX2 | BIOGRID; |
interacts with |
SIRT1 | BIOGRID; |
interacts with |
SIRT1 | HPRD; |
interacts with |
SPTAN1 | BIOGRID; |
interacts with |
SSA1 | INTACT; |
interacts with |
SSA2 | INTACT; |
interacts with |
SSB1 | INTACT; |
interacts with |
SSE1 | INTACT; |
interacts with |
STAT3 | HPRD; |
interacts with |
TLE1 | HPRD; |
interacts with |
TLE2 | BIOGRID; |
interacts with |
UBQLN1 | HPRD; |
Metabolic Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
metabolic catalysis |
ATF2 | NCI_NATURE; |
metabolic catalysis |
EP300 | NCI_NATURE; |
metabolic catalysis |
HDAC1 | NCI_NATURE; |
metabolic catalysis |
HES1 | NCI_NATURE; |
metabolic catalysis |
JUN | NCI_NATURE; |
metabolic catalysis |
NOTCH1 | NCI_NATURE; |
metabolic catalysis |
NOTCH1 | REACTOME; |
metabolic catalysis |
RBPJ | NCI_NATURE; |
metabolic catalysis |
SPEN | NCI_NATURE; |
metabolic catalysis |
TWIST1 | NCI_NATURE; |
Signaling Interaction [Top] | ||
Interaction Type | Interactor | Data Source |
|---|---|---|
reacts with |
APITD1 | NCI_NATURE; |
reacts with |
BLM | NCI_NATURE; |
reacts with |
CREBBP | NCI_NATURE; |
reacts with |
EP300 | NCI_NATURE; |
reacts with |
FAAP100 | NCI_NATURE; |
reacts with |
FAAP24 | NCI_NATURE; |
reacts with |
FANCA | NCI_NATURE; |
reacts with |
FANCB | NCI_NATURE; |
reacts with |
FANCC | NCI_NATURE; |
reacts with |
FANCE | NCI_NATURE; |
reacts with |
FANCF | NCI_NATURE; |
reacts with |
FANCG | NCI_NATURE; |
reacts with |
FANCL | NCI_NATURE; |
reacts with |
FANCM | NCI_NATURE; |
reacts with |
GATA1 | NCI_NATURE; |
reacts with |
HES1 | NCI_NATURE; |
reacts with |
HES6 | NCI_NATURE; |
reacts with |
JAK2 | NCI_NATURE; |
reacts with |
MYB | NCI_NATURE; |
reacts with |
NOTCH1 | NCI_NATURE; |
reacts with |
PARP1 | NCI_NATURE; |
reacts with |
PTF1A | NCI_NATURE; |
reacts with |
RB1 | NCI_NATURE; |
reacts with |
RBPJ | NCI_NATURE; |
reacts with |
RMI1 | NCI_NATURE; |
reacts with |
RUNX2 | NCI_NATURE; |
reacts with |
TLE1 | NCI_NATURE; |
reacts with |
TOP3A | NCI_NATURE; |
reacts with |
UBE2T | NCI_NATURE; |
state change |
APITD1 | NCI_NATURE; |
state change |
ATR | NCI_NATURE; |
state change |
ATRIP | NCI_NATURE; |
state change |
CAMK2D | NCI_NATURE; |
state change |
CHEK1 | NCI_NATURE; |
state change |
FAAP24 | NCI_NATURE; |
state change |
FANCM | NCI_NATURE; |
state change |
HUS1 | NCI_NATURE; |
state change |
RAD17 | NCI_NATURE; |
state change |
RAD1 | NCI_NATURE; |
state change |
RAD9A | NCI_NATURE; |
state change |
RFC2 | NCI_NATURE; |
state change |
RFC3 | NCI_NATURE; |
state change |
RFC4 | NCI_NATURE; |
state change |
RFC5 | NCI_NATURE; |
state change |
RPA1 | NCI_NATURE; |
state change |
RPA2 | NCI_NATURE; |
state change |
TOPBP1 | NCI_NATURE; |