| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3084 |
Name | NRG1 |
Synonymous | ARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|NDF|SMDF;neuregulin 1;NRG1;neuregulin 1 |
Definition | MSTP131|glial growth factor|heregulin, alpha (45kD, ERBB2 p185-activator)|neu differentiation factor|neuregulin 1 type IV beta 1a|neuregulin 1 type IV beta 3|pro-NRG1|pro-neuregulin-1, membrane-bound isoform|sensory and motor neuron derived factor |
Position | 8p12 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | ErbB4(h) + NRG1(h) <==> ErbB4(h):NRG1(h) (binding) | NRG1(h) + (ErbB4(m))2 <==> NRG1(h):(ErbB4(m))2 (binding) | NRG1(h) + ErbB2(m.s.):ErbB4(m) <==> NRG1(h):ErbB2(m.s.):ErbB4(m) (binding) | NRG1(h) + (ErbB3(m.s.))2 <==> NRG1(h):(ErbB3(m.s.))2 (binding) | NRG1(h) + ErbB2(m.s.):ErbB3(m.s.) <==> NRG1(h):ErbB2(m.s.):ErbB3(m.s.) (binding) | NRG1(h) --> ERK(h){pY} (increase of phosphorylation) | NRG1(h) --> AKT-1(h){pS473} (increase of phosphorylation) | NRG1(h) --/ ErbB4(h) (decrease of abundance) | NRG1(h) --/ cyclinD1(h) (decrease of abundance) | NRG1(h) --/ pRb(h){p} (decrease of abundance) | NRG1(h) --> cyclinB1(h) (increase of abundance) | NRG1(h) --> Cdk1(h){pY15} (decrease of phosphorylation) | NRG1(h) --> cyclinB1(h):Cdk1(h) (increase of binding) | NRG1(h) --> brca1(h) (increase of abundance) | NRG1(h) --> ERK1(h){pY} (increase of phosphorylation) | NRG1(h) --> ERK2(h){pY} (increase of phosphorylation) | NRG1(h) --> JNK2(h){p} (increase of phosphorylation) | NRG1(h) --> ErbB3(h){pY} (increase of phosphorylation) | NRG1(h) --> ErbB3(h){pY1289} (increase of phosphorylation) | NRG1(h) --> EGFR(h):ErbB3(h){pY1289} (increase of binding) | NRG1(h) --> ErbB3(m){pY1286} (increase of phosphorylation) | NRG1(h) --> NRG1(h) (expression). | NRG1-beta1(h) + ErbB4(h) <==> NRG1-beta1(h):ErbB4(h) (binding) | NRG1-beta1(h) --> ErbB2(h){pY} (increase of phosphorylation) | NRG1-beta1(h) --> ErbB3(h){pY} (increase of phosphorylation) | NRG1-beta1(h) --> ErbB2(h){pY}:PLCgamma1(h) (decrease of binding) | NRG1-beta1(h) --> Shc-1-p52(h):ErbB2(h){pY} (increase of phosphorylation) | NRG1-beta1(h) --> Shc-1-p52(h):ErbB3(h){pY} (increase of binding) | NRG1-beta1(h) --> Grb-2(h):ErbB3(h){pY} (increase of binding) | NRG1-beta1(h) --> p85(h):ErbB3(h){pY} (increase of binding) | NRG1-beta1(h) --> ERK1(h){p} (increase of phosphorylation) | NRG1-beta1(h) --> p38(h){p} (increase of phosphorylation) | NRG1-beta1(h) --> JNK(h){p} (increase of phosphorylation) | NRG1-beta1(h) --> c-Jun(m.s.){p} (increase of phosphorylation) | NRG1-beta1(h) --> AKT(h){p} (increase of phosphorylation) | NRG1-beta1(h) --> p70S6K(h){pS411} (increase of phosphorylation) | NRG1-beta1(h) --> ErbB3(h){pY}:ErbB2(h){pY} (increase of binding) | NRG1-beta1(h) --> Shc-1-p46(h):ErbB2(h){pY} (increase of binding) | NRG1-beta1(h) + ErbB3(h):ErbB2(h) <==> NRG1-beta1(h):ErbB3(h):ErbB2(h) (binding) | NRG1-beta1(h) + ErbB4(h):ErbB2(h) <==> NRG1-beta1(h):ErbB4(h):ErbB2(h) (binding) | NRG1-beta1(h) + ErbB3-isoform1(h):ErbB2(ha) <==> NRG1-beta1(h):ErbB3-isoform1(h):ErbB2(ha) (binding) | NRG1-beta1(h) + ErbB4(h):ErbB2(ha) <==> ErbB2(ha):ErbB4(h):NRG1-beta1(h) (binding) | NRG1-beta1(h) --> AKT-1(r){pT308}{pS473} (increase of phosphorylation) | NRG1-beta1(h) --> ERK(h){p} (increase of phosphorylation) | NRG1-beta1(h) --> AKT-1(m){pS473} (increase of phosphorylation) | NRG1-beta1(h) --> Src(h){pY216} (increase of phosphorylation) | NRG1-beta1(h) --> FAK1(h){pY861} (increase of phosphorylation) | NRG1-beta1(h) --> AKT-1(h){pS473} (increase of phosphorylation) | NRG1-beta1(h) --> ErbB2(m){pY} (increase of phosphorylation) | NRG1-beta1(h) --> ErbB3(m){pY} (increase of phosphorylation) | NRG1-beta1(h) --> ErbB4(m){pY} (increase of phosphorylation) | NRG1-beta1(h) --> ErbB4(h){pY} (increase of phosphorylation) | NRG1-beta1(h) --> ErbB4(m.s.){pY} (increase of phosphorylation) | NRG1-beta1(h) --> ERK2(h){p} (increase of phosphorylation) | NRG1-beta1(h) --> ErbB4-JM-A(h){pY} (increase of phosphorylation) | NRG1-beta1(h) --> ErbB4-JM-B(h){pY} (increase of phosphorylation) | NRG1-beta1(h) --> Bmx(m.s.){pY} (increase of phosphorylation) | NRG1(h) --> NRG1-beta1(h) (expression). | NRG1(h) --> NRG1-SMDF(h) (expression). | NRG1-alpha1A(h) --> ErbB4-JM-A(h){pY} (increase of phosphorylation) | NRG1-alpha1A(h) --> ErbB4-JM-B(h){pY} (increase of phosphorylation) | NRG1(h) --> NRG1-alpha1A(h) (expression). | NRG1(h) --> NRG1-alpha2B(h) (expression). | NRG1(h) --> NRG1-Alpha3(h) (expression). | NRG1(h) --> NRG1-beta2(h) (expression). | NRG1-beta3(h) --> ERK1(h){pY} (increase of phosphorylation) | NRG1-beta3(h) --> ERK2(h){pY} (increase of phosphorylation) | NRG1-beta3(h) --> Shc-1-p46(h){pY} (increase of phosphorylation) | NRG1-beta3(h) --> Shc-1-p52(h){pY} (increase of phosphorylation) | NRG1-beta3(h) --> Shc-1(h):ErbB2(h) (increase of binding) | NRG1-beta3(h) --> Shc-1(h):ErbB3(h) (increase of binding) | NRG1-beta3(h) --> Shc-1(h):Grb-2(h) (increase of binding) | NRG1-beta3(h) --> FOS(h) (transactivation) | NRG1(h) --> NRG1-beta3(h) (expression). | NRG1-GGF2(h) --> AKT(r){p} (increase of phosphorylation) | NRG1-GGF2(h) --> ERK1(r){p} (increase of phosphorylation) | NRG1-GGF2(h) --> ERK2(r){p} (increase of phosphorylation) | NRG1-GGF2(h) --> AKT-1(m.s.){p} (increase of phosphorylation) | NRG1-GGF2(h) --> bad(r){pS112} (increase of phosphorylation) | NRG1(h) --> NRG1-GGF2(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 120 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 126 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 164 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr8 |
Promoter: 32523795 - 32525795 | Agilent_014791 |
chr8 |
Promoter: 32523795 - 32525795 | Agilent_014791 |
chr8 |
Promoter: 31615310 - 31617310 | Agilent_014791 |
chr8 |
Promoter: 32523795 - 32525795 | Agilent_014791 |
chr8 |
Promoter: 32523795 - 32525795 | GoldenGate_Methylation_Cancer_Panel_I |
chr8 |
Promoter: 32523795 - 32525795 | GoldenGate_Methylation_Cancer_Panel_I |
chr8 |
Promoter: 32523795 - 32525795 | GoldenGate_Methylation_Cancer_Panel_I |
chr8 |
Promoter: 32523795 - 32525795 | GoldenGate_Methylation_Cancer_Panel_I |
chr8 |
Promoter: 32523795 - 32525795 | GoldenGate_Methylation_Cancer_Panel_I |
chr8 |
Promoter: 32523795 - 32525795 | GoldenGate_Methylation_Cancer_Panel_I |
chr8 |
Promoter: 32523795 - 32525795 | GoldenGate_Methylation_Cancer_Panel_I |
chr8 |
Promoter: 32622571 - 32624571 | GSE27584 |
chr8 |
Promoter: 32523795 - 32525795 | GSE27584 |
chr8 |
Promoter: 32523795 - 32525795 | GSE27584 |
chr8 |
Promoter: 32523795 - 32525795 | GSE27584 |
chr8 |
Promoter: 32523795 - 32525795 | GSE27584 |
chr8 |
Promoter: 32523795 - 32525795 | GSE27584 |
chr8 |
Promoter: 31615310 - 31617310 | GSE27584 |
chr8 |
Promoter: 32523795 - 32525795 | GSE27584 |
chr8 |
Promoter: 31615310 - 31617310 | Agilent_014791_44K |