| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3084 |
Name | NRG1 |
Synonymous | ARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|NDF|SMDF;neuregulin 1;NRG1;neuregulin 1 |
Definition | MSTP131|glial growth factor|heregulin, alpha (45kD, ERBB2 p185-activator)|neu differentiation factor|neuregulin 1 type IV beta 1a|neuregulin 1 type IV beta 3|pro-NRG1|pro-neuregulin-1, membrane-bound isoform|sensory and motor neuron derived factor |
Position | 8p12 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for NRG1 | ||
PCGP somatic mutation [Top] | ||
Variant (Variant; Chr; Position) | Genotype (MutationType; MutationClass; ReferenceAllele; Genotype; Origin) | Disease (CancerType; ValidationStatus; SequencingType) |
|---|---|---|
NRG1_A263A; chr8; 32611978 |
SUB; SILENT; C; C/T; SOMATIC | RHB; VALID; WGS |
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.845G>A; p.R282H; |
large_intestine | carcinoma; adenocarcinoma |
c.1456G>A; p.V486M; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.1456G>A; p.V486M; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.568T>G; p.C190G; |
lung | carcinoma; small_cell_carcinoma |
c.997G>A; p.A333T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1595C>T; p.T532M; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1243G>T; p.E415*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.916C>A; p.P306T; |
pancreas | carcinoma |
c.1421G>T; p.S474I; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.421G>T; p.A141S; |
large_intestine | carcinoma; adenocarcinoma |
c.634T>C; p.C212R; |
prostate | carcinoma; adenocarcinoma |
c.279G>A; p.G93G; |
oesophagus; lower_third | carcinoma; adenocarcinoma |
c.1811T>G; p.L604R; |
oesophagus | carcinoma; adenocarcinoma |
c.447T>G; p.S149S; |
oesophagus | carcinoma; adenocarcinoma |
c.112C>T; p.R38*; |
oesophagus | carcinoma; adenocarcinoma |
c.769G>A; p.A257T; |
oesophagus | carcinoma; adenocarcinoma |
c.512C>T; p.T171I; |
oesophagus | carcinoma; adenocarcinoma |
c.447T>G; p.S149S; |
oesophagus | carcinoma; adenocarcinoma |
c.710T>C; p.F237S; |
oesophagus | carcinoma; adenocarcinoma |
c.1190T>A; p.L397H; |
oesophagus | carcinoma; adenocarcinoma |
c.1254T>G; p.D418E; |
oesophagus | carcinoma; adenocarcinoma |
c.574A>C; p.N192H; |
oesophagus | carcinoma; adenocarcinoma |
c.1190T>G; p.L397R; |
oesophagus | carcinoma; adenocarcinoma |
c.1148A>G; p.N383S; |
lung | carcinoma; large_cell_carcinoma |
c.1635A>G; p.K545K; |
liver | carcinoma |
c.992G>C; p.R331T; |
lung | carcinoma; adenocarcinoma |
c.1616C>G; p.A539G; |
lung | carcinoma; adenocarcinoma |
c.325G>C; p.E109Q; |
lung | carcinoma; adenocarcinoma |
c.1358C>A; p.P453H; |
lung | carcinoma; adenocarcinoma |
c.568T>G; p.C190G; |
lung | carcinoma; adenocarcinoma |
c.681C>T; p.A227A; |
prostate | adenoma |
c.1819A>T; p.T607S; |
ovary | carcinoma; serous_carcinoma |
c.1486T>A; p.F496I; |
lung | carcinoma; squamous_cell_carcinoma |
c.384C>A; p.T128T; |
lung | carcinoma; squamous_cell_carcinoma |
c.1866C>A; p.R622R; |
lung | carcinoma; squamous_cell_carcinoma |
c.951C>T; p.Y317Y; |
lung | carcinoma; squamous_cell_carcinoma |
c.411T>G; p.T137T; |
ovary | carcinoma; serous_carcinoma |
c.1456G>T; p.V486L; |
lung | carcinoma; adenocarcinoma |
c.1077-2A>T; p.?; |
lung | carcinoma; squamous_cell_carcinoma |
c.1899G>T; p.L633L; |
lung | carcinoma; squamous_cell_carcinoma |
c.1533G>A; p.A511A; |
lung | carcinoma; adenocarcinoma |
c.1456G>T; p.V486L; |
lung | carcinoma; adenocarcinoma |
c.1596G>T; p.T532T; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.1141G>A; p.V381I; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.1795C>G; p.P599A; |
ovary | carcinoma; serous_carcinoma |
c.1141G>A; p.V381I; |
lung | carcinoma; adenocarcinoma |
c.750C>T; p.T250T; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.1271C>T; p.P424L; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.845G>A; p.R282H; |
breast | carcinoma |
c.1882G>A; p.E628K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.289C>A; p.L97I; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.863G>A; p.R288Q; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.216G>T; p.K72N; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1415C>T; p.A472V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1365G>T; p.S455S; |
breast | carcinoma |
c.1639G>A; p.A547T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.625T>A; p.L209M; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1365G>A; p.S455S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.266delA; p.K91fs*24; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1768G>T; p.D590Y; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1381G>A; p.V461M; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.871C>T; p.R291*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.764G>A; p.C255Y; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.399C>T; p.N133N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.991A>G; p.R331G; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.647T>G; p.F216C; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1593A>C; p.E531D; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1764_1765insG; p.E589fs*17; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.293G>A; p.R98H; |
endometrium | carcinoma; endometrioid_carcinoma |
c.494C>A; p.T165N; |
endometrium | carcinoma; endometrioid_carcinoma |
c.583G>A; p.E195K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.242A>G; p.N81S; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1661G>T; p.R554I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.850C>T; p.R284W; |
endometrium | carcinoma; endometrioid_carcinoma |
c.391G>A; p.E131K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.766A>G; p.I256V; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1533G>A; p.A511A; |
endometrium | carcinoma; endometrioid_carcinoma |
c.691+4C>T; p.?; |
endometrium | carcinoma; endometrioid_carcinoma |
c.266delA; p.K91fs*24; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.266delA; p.K91fs*24; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.818A>G; p.K273R; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1474C>T; p.R492W; |
endometrium | carcinoma; endometrioid_carcinoma |
c.482delA; p.G162fs*19; |
endometrium | carcinoma; endometrioid_carcinoma |
c.168G>A; p.R56R; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1416G>A; p.A472A; |
endometrium | carcinoma; endometrioid_carcinoma |
c.952G>A; p.V318I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.904C>T; p.H302Y; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1466C>A; p.P489Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.140C>T; p.S47L; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.702G>A; p.G234G; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1243G>T; p.E415*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1397T>C; p.V466A; |
endometrium | carcinoma; endometrioid_carcinoma |
c.850C>T; p.R284W; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1639G>A; p.A547T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1126A>C; p.I376L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1454T>G; p.L485R; |
endometrium | carcinoma; endometrioid_carcinoma |
c.969C>G; p.I323M; |
urinary_tract; bladder | carcinoma |
c.1220A>C; p.N407T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1124T>C; p.V375A; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1600C>A; p.Q534K; |
urinary_tract; bladder | carcinoma |
c.1502A>G; p.Q501R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1398G>T; p.V466V; |
prostate | carcinoma |
c.1067C>T; p.P356L; |
skin | malignant_melanoma |
c.1256C>T; p.S419F; |
skin | malignant_melanoma |
c.523G>A; p.G175R; |
skin | malignant_melanoma |
c.226G>A; p.E76K; |
skin; mucosal | malignant_melanoma |
c.1079G>A; p.W360*; |
skin; scalp | carcinoma; squamous_cell_carcinoma |
c.266delA; p.K91fs*24; |
stomach | adenocarcinoma |