| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 2956 |
Name | MSH6 |
Synonymous | GTBP|HNPCC5|HSAP;mutS homolog 6 (E. coli);MSH6;mutS homolog 6 (E. coli) |
Definition | DNA mismatch repair protein Msh6|G/T mismatch-binding protein|GTMBP|hMSH6|mutS-alpha 160 kDa subunit|p160|sperm-associated protein |
Position | 2p16 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | PCNA(h) + GTBP-N(h) <==> PCNA(h):GTBP-N(h) (binding) | MSH6(h) --> GTBP-N(h) (expression). | MSH6(h) --> GTBP-alt(h) (expression). | PCNA(h) + GTBP(h) <==> PCNA(h):GTBP(h) (binding) | MSH2(h) + GTBP(h) <==> MSH2(h):GTBP(h) (binding) | PMS2(h) + GTBP(h) <==> PMS2(h):GTBP(h) (binding) | GTBP(h) + BLM(h) <==> GTBP(h):BLM(h) (binding) | GTBP(h) + Rad51(h) <==> GTBP(h):Rad51(h) (binding) | GTBP(h) + p53(h) <==> GTBP(h):p53(h) (binding) | RFC4(h) + RFC2(h) + MLH1(h) + MSH2(h) + RECC1(h) + BLM(h) + ATM(h) + brca1(h) + GTBP(h) <==> RFC4(h):RFC2(h):MLH1(h):MSH2(h):RECC1(h):BLM(h):ATM(h):brca1(h):GTBP(h) (binding) | brca1(h) + Rad50(h) + GTBP(h) <==> brca1(h):Rad50(h):GTBP(h) (binding) | brca1(h) + GTBP(h) <==> brca1(h):GTBP(h) (binding) | GTBP(h) + Rad50(h) <==> GTBP(h):Rad50(h) (binding) | GTBP(h) + ATM(h) <==> GTBP(h):ATM(h) (binding) | RECC1(h) + GTBP(h) <==> RECC1(h):GTBP(h) (binding) | GTBP(h) + MLH1(h) <==> GTBP(h):MLH1(h) (binding) | brca1(m.s.) + GTBP(h) <==> brca1(m.s.):GTBP(h) (binding) | MSH2(h) + GTBP(h) + brca1(m.s.) + GCN5(h) + trrap(h) <==> MSH2(h):GTBP(h):brca1(m.s.):GCN5(h):trrap(h) (binding) | TAFII30(h) + TAF(II)31(h) + supt3h(h) + ADA3(h) + PAF65B(h) + MSH2(h) + GTBP(h) + trrap(h) + GCN5(h) + brca1(m.s.) <==> TAFII30(h):TAF(II)31(h):supt3h(h):ADA3(h):PAF65B(h):MSH2(h):GTBP(h):trrap(h):GCN5(h):brca1(m.s.) (binding) | c-Myc(h) + GTBP(h) <==> c-Myc(h):GTBP(h) (binding) | Caspase-4(h) + GTBP(h) <==> Caspase-4(h):GTBP(h) (binding) | GTBP(h) + p300(h) <==> GTBP(h):p300(h) (binding) | GTBP(h) + CBP(h) <==> GTBP(h):CBP(h) (binding) | GTBP(h) + RCOR1(h) <==> GTBP(h):RCOR1(h) (binding) | MSH6(h) --> GTBP(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 14 | Phosphoserine. | Swiss-Prot 53.0 | 41 | Phosphoserine. | Swiss-Prot 53.0 | 43 | Phosphoserine. | Swiss-Prot 53.0 | 137 | Phosphoserine. | Swiss-Prot 53.0 | 219 | Phosphoserine. | Swiss-Prot 53.0 | 227 | Phosphoserine. | Swiss-Prot 53.0 | 252 | Phosphoserine. | Swiss-Prot 53.0 | 254 | Phosphoserine. | Swiss-Prot 53.0 | 256 | Phosphoserine. | Swiss-Prot 53.0 | 261 | Phosphoserine. | Swiss-Prot 53.0 | 830 | Phosphoserine. | Swiss-Prot 53.0 | 924 | Phosphothreonine. | Swiss-Prot 53.0 | 261 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 252 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 254 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 256 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 227 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 830 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 137 | Phosphoserine | 16565220 | Phospho.ELM 6.0 | 924 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 47862290 - 47864290 | Agilent_014791 |
chr2 |
Promoter: 47862290 - 47864290 | GSE27584 |
chr2 |
Promoter: 47862290 - 47864290 | Agilent_014791_44K |
chr2 |
Promoter: 47862290 - 47864290 | Agilent_014791 |