| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 2908 |
Name | NR3C1 |
Synonymous | GCCR|GCR|GR|GRL;nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor);NR3C1;nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
Definition | glucocorticoid nuclear receptor variant 1|glucocorticoid receptor|nuclear receptor subfamily 3 group C member 1 variant DL-1|nuclear receptor subfamily 3 group C member 1 variant NS-1 |
Position | 5q31.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | GR-alpha(h) + Trx1(h) <==> GR-alpha(h):Trx1(h) (binding) | GR-alpha(h) --> CGA(h) (DNA binding). | GR-alpha(h) --> LYS(c) (DNA binding; transregulation). | GR-alpha(h) --> TAT(r) (DNA binding; transregulation). | GR-alpha(h) --> IL6(h) (DNA binding; transregulation). | c-Fos(h) + GR-alpha(h) <==> c-Fos(h):GR-alpha(h) (binding). | GR-alpha(h) + c-Jun(h) <==> GR-alpha(h):c-Jun(h) (binding). | Hsp90(h) + GR-alpha(h) <==> Hsp90(h):GR-alpha(h) (binding). | FKBP59(h) + GR-alpha(h) <==> FKBP59(h):GR-alpha(h) (binding). | hsp56(h) + GR-alpha(h) <==> hsp56(h):GR-alpha(h) (binding). | POU2F1(ha) + GR-alpha(h) <==> POU2F1(ha):GR-alpha(h) (binding). | GR-beta(h) + GR-alpha(h) <==> GR-beta(h):GR-alpha(h) (binding). | GR-alpha(h) --> IGFBP1(h) (DNA binding; transactivation). | GR-alpha(h) + GR-alpha(h) <==> GR-alpha(h):GR-alpha(h) (binding). | GR-alpha(h) + AP-1(h) <==> GR-alpha(h):AP-1(h) (binding). | POU2F1a(m) + GR-alpha(h) <==> POU2F1a(m):GR-alpha(h) (binding). | G-beta-2(h) + GR-alpha(h) <==> G-beta-2(h):GR-alpha(h) (binding) | GR-alpha(h) + G-beta-1(h) <==> GR-alpha(h):G-beta-1(h) (binding) | RACK1(h) + GR-alpha(h) <==> RACK1(h):GR-alpha(h) (binding) | GR-alpha(h) --> GR-alpha(h) (translocation) | GR-alpha(h) + 14-3-3sigma(h) <==> GR-alpha(h):14-3-3sigma(h) (binding) | GR-alpha(h) + 14-3-3eta(m.s.) <==> GR-alpha(h):14-3-3eta(m.s.) (binding) | GR-alpha(h) + DAP3(h) <==> GR-alpha(h):DAP3(h) (binding) | NF-IL6-3(h) + GR-alpha(h) <==> NF-IL6-3(h):GR-alpha(h) (binding) | GR-alpha(h) --> GR-alpha(h) (translocation) | GR-alpha(h) --/ IGFBP1(h) (DNA binding; transrepression). | GR-alpha(h) --> protein remnants (degradation) | GR-alpha(h) --> Wap(r) (transactivation) | NR3C1(h) --> GR-alpha(h) (expression). | relaxin-2(h) --> GR-alpha(h) (increase of abundance) | GR-alpha(h) --> GR-alpha(h) (translocation) | GR-alpha(h) --> GR-alpha(h) (translocation) | estradiol --/ GR-alpha(h) (decrease of abundance) | GR-beta(h) --> IL6(h) (DNA binding; transregulation). | GR-beta(h) --> TAT(r) (DNA binding; transregulation). | GR-beta(h) --> LYS(c) (DNA binding; transregulation). | GR-beta(h) --> CGA(h) (DNA binding). | GR-beta(h) + c-Fos(h) <==> GR-beta(h):c-Fos(h) (binding). | GR-beta(h) + c-Jun(h) <==> GR-beta(h):c-Jun(h) (binding). | GR-beta(h) + GR-alpha(h) <==> GR-beta(h):GR-alpha(h) (binding). | GR-beta(h) + FKBP59(h) <==> GR-beta(h):FKBP59(h) (binding). | GR-beta(h) + Hsp90(h) <==> GR-beta(h):Hsp90(h) (binding). | GR-beta(h) + hsp56(h) <==> GR-beta(h):hsp56(h) (binding). | GR-beta(h) + POU2F1(ha) <==> GR-beta(h):POU2F1(ha) (binding). | GR-beta(h) + AP-1(h) <==> GR-beta(h):AP-1(h) (binding). | GR-beta(h) + POU2F1a(m) <==> GR-beta(h):POU2F1a(m) (binding). | GR-beta(h) --> NR3C1(h) (DNA binding). | NR3C1(h) --> GR-beta(h) (expression). | relaxin-2(h) --> GR-beta(h) (increase of abundance) | GR(h) + 14-3-3eta(h) <==> GR(h):14-3-3eta(h) (binding) | GR(h) + PKAc(m) <==> GR(h):PKAc(m) (binding) | GR(h) --/ BGLAP(h) (DNA binding; transrepression). | GR(h) --> Orm1(m) (DNA binding). | GR(h) --> B1AR(s) (DNA binding). | GR(h) --> CRH(h) (DNA binding). | GR(h) --> GST-Y A2(r) (DNA binding). | GR(h) --> Aldh3a1(r) (DNA binding). | GR(h) --> AFP(h) (DNA binding; transactivation). | GR(h) --> CYP2C9(h) (DNA binding; transactivation). | GR(h) + STAT5A(m) <==> GR(h):STAT5A(m) (binding) | GR(h) --> NR1I3(h) (DNA binding). | GR(h) + MVP(h) <==> GR(h):MVP(h) (binding) | GR(h) + DP97-xbb2(h) <==> GR(h):DP97-xbb2(h) (binding) | PIAS2(m.s.) + GR(h) <==> PIAS2(m.s.):GR(h) (binding) | ELL(m.s.) + GR(h) <==> ELL(m.s.):GR(h) (binding) | ASC-2(r) + GR(h) <==> ASC-2(r):GR(h) (binding) | ASC-2(h) + GR(h) <==> ASC-2(h):GR(h) (binding) | GT198(r) + GR(h) <==> GT198(r):GR(h) (binding) | GR(h) + GT198(h) <==> GR(h):GT198(h) (binding) | GR(h) + relaxin(h) <==> GR(h):relaxin(h) (binding) | Hsp70(h) + GR(h) <==> Hsp70(h):GR(h) (binding) | Hsp90(h) + GR(h) <==> Hsp90(h):GR(h) (binding) | GR(h) + RIP140(h) <==> GR(h):RIP140(h) (binding) | 14-3-3eta(h) + GR(h) <==> 14-3-3eta(h):GR(h) (binding) | RIP140(h) + GR(h) + 14-3-3eta(h) <==> RIP140(h):GR(h):14-3-3eta(h) (binding) | GR(h) + DRIP205-isoform4(m) <==> GR(h):DRIP205-isoform4(m) (binding) | GR(h) + SRC3(h) <==> GR(h):SRC3(h) (binding) | GR(h) + SRC-1(h) <==> GR(h):SRC-1(h) (binding) | GR(h) + TIF2(m) <==> GR(h):TIF2(m) (binding) | GR(h) + RXR-alpha(h) <==> GR(h):RXR-alpha(h) (binding) | GR(h) + G-beta(h) <==> GR(h):G-beta(h) (binding) | GR(h) + G-gamma(h) <==> GR(h):G-gamma(h) (binding) | SRP1alpha(m) + GR(h) <==> SRP1alpha(m):GR(h) (binding) | importin-7(x) + GR(h) <==> importin-7(x):GR(h) (binding) | GR(h) + importin-8(h) <==> GR(h):importin-8(h) (binding) | GR(h) --> UGT1A1(h) (DNA binding). | GR(h) --> GR(h) (translocation) | NF-kappaB1-isoform1(h) + GR(h) <==> NF-kappaB1-isoform1(h):GR(h) (binding) | RelA-p65(h) + GR(h) <==> RelA-p65(h):GR(h) (binding) | TRAP170(m.s.) + GR(h) <==> TRAP170(m.s.):GR(h) (binding) | DRIP205(m.s.) + GR(h) <==> DRIP205(m.s.):GR(h) (binding) | GR(h) --> Pnmt(r) (DNA binding; transactivation). | GR(h) --> NR3C1(h) (DNA binding). | GR(h) + hnRNPA1(h) <==> GR(h):hnRNPA1(h) (binding) | GR(h) --> CSH1(h) (DNA binding). | GR(h) --> CD38(h) (DNA binding). | ska2(h) + GR(h) <==> ska2(h):GR(h) (binding) | GR(h) + ska2(m.s.) <==> GR(h):ska2(m.s.) (binding) | GR(h) --/ POMC(h) (transrepression) | GR(h) --> Orm2(m) (DNA binding; transactivation). | GR(h) --> PLA2G4A(h) (DNA binding). | GR(h) + HNF-4alpha(h) <==> HNF-4alpha(h):GR(h) (binding) | GR(h) --> Agtr1b(r) (DNA binding). | GR(h) --> FKBP5(h) (DNA binding). | NR3C1(h) --> GR(h) (expression). | ARA70(m.s.) --> GR(h) (activation) | PIAS2(m.s.) --> GR(h) (regulation of protein activity) | GR(h) --> GR(h) (translocation) | NR3C1(h) --> GR-Alpha-2(h) (expression). | NR3C1(h) --> GR-Beta-2(h) (expression). | NR3C1(h) --> GR-Abeta(h) (expression). |
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Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 113 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 141 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 203 | Phosphoserine. | Swiss-Prot 53.0 | 211 | Phosphoserine. | Swiss-Prot 53.0 | 226 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 277 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO). | Swiss-Prot 53.0 | 293 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO). | Swiss-Prot 53.0 | 508 | Phosphoserine (DNA-PK) | 9038175 | Phospho.ELM 6.0 | 203 | Phosphoserine | 12000743 | Phospho.ELM 6.0 | 211 | Phosphoserine | 15817653 | Phospho.ELM 6.0 | 141 | Phosphoserine | 7873448;2019585 | Phospho.ELM 6.0 | 113 | Phosphoserine | 7873448;2019585 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr5 |
Promoter: 142763738 - 142765738 | Agilent_014791 |
chr5 |
Promoter: 142762947 - 142764947 | Agilent_014791 |
chr5 |
Promoter: 142762947 - 142764947 | GSE27584 |
chr5 |
Promoter: 142763738 - 142765738 | GSE27584 |
chr5 |
Promoter: 142762947 - 142764947 | GSE27584 |
chr5 |
Promoter: 142762947 - 142764947 | GSE27584 |
chr5 |
Promoter: 142762947 - 142764947 | Agilent_014791_44K |
chr5 |
Promoter: 142762947 - 142764947 | PMID:17167179 |
chr5 |
Promoter: 142794770 - 142796770 | PMID:17167179 |
chr5 |
Promoter: 142794770 - 142796770 | PMID:17167179 |
chr5 |
Promoter: 142763738 - 142765738 | PMID:17167179 |
chr5 |
Promoter: 142794770 - 142796770 | PMID:17167179 |
chr5 |
Promoter: 142762947 - 142764947 | PMID:17167179 |
chr5 |
Promoter: 142762947 - 142764947 | PMID:17167179 |