| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 25 |
Name | ABL1 |
Synonymous | ABL|JTK7|bcr/abl|c-ABL|p150|v-abl;c-abl oncogene 1, non-receptor tyrosine kinase;ABL1;c-abl oncogene 1, non-receptor tyrosine kinase |
Definition | Abelson tyrosine-protein kinase 1|bcr/c-abl oncogene protein|c-abl oncogene 1, receptor tyrosine kinase|proto-oncogene c-Abl|proto-oncogene tyrosine-protein kinase ABL1|tyrosine-protein kinase ABL1|v-abl Abelson murine leukemia viral oncogene homolog 1 |
Position | 9q34.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Abl(h) + WAVE-1(h) <==> Abl(h):WAVE-1(h) (binding) | Abl(h) --> HBV enhancer(HBV) (DNA binding). | Abl(h) + SHIP2-isoform1(h){pY} <==> Abl(h):SHIP2-isoform1(h){pY} (binding) | Abl(h) + p73alpha(h) <==> Abl(h):p73alpha(h) (binding) | Abl(h) --Caspase-3(h)--> Abl-p120(h) + Abl-p75(h) + Abl-p60(h) + Abl-p22(h) (processing) | Abl(h) --Caspase-6(h)--> Abl-p120(h) + Abl-p75(h) + Abl-p60(h) + Abl-p22(h) (processing) | Abl(h) --Caspase-7(h)--> Abl-p120(h) + Abl-p75(h) + Abl-p60(h) + Abl-p22(h) (processing) | Abl(h) --Caspase-8(h)--> Abl-p120(h) + Abl-p75(h) + Abl-p60(h) + Abl-p22(h) (processing) | Abl(h) + Rad9a(h) <==> Abl(h):Rad9a(h) (binding) | Abl(h) + ATP --> Abl(h){pY} + ADP (phosphorylation) | p73(h) + Abl(h) <==> p73(h):Abl(h) (binding) | Abl(h) + MEKK1(h) <==> Abl(h):MEKK1(h) (binding) | TopoI(h) + Abl(h) <==> TopoI(h):Abl(h) (binding) | Abl(h) + TopoI(m.s.) <==> Abl(h):TopoI(m.s.) (binding) | MEKK1(h) + Abl(h) <==> MEKK1(h):Abl(h) (binding) | Abl(h) + RIN1(h) <==> Abl(h):RIN1(h) (binding) | Abl(h) + CrkL(m.s.) <==> Abl(h):CrkL(m.s.) (binding) | Abl(h) + CrkL(h) <==> Abl(h):CrkL(h) (binding) | proCaspase-9(h) + Abl(h) <==> proCaspase-9(h):Abl(h) (binding) | proCaspase-9(m.s.) + Abl(h) <==> proCaspase-9(m.s.):Abl(h) (binding) | ErbB1-p170(h){pY1110} + Abl(h) <==> Abl(h):ErbB1-p170(h){pY1110} (binding) | Abl(h) + acetyl-CoA --p300(m.s.)--> Abl(h){aceK} + CoA (acetylation) | Abl(h) + acetyl-CoA --CBP(m.s.)--> Abl(h){aceK} + CoA (acetylation) | Abl(h) + acetyl-CoA --p/CAF(m.s.)--> Abl(h){aceK} + CoA (acetylation) | Abl(h) --> Abl(h) (translocation) | Abl(h) + ErbB2(h){pY1139}{pY1222} <==> Abl(h):ErbB2(h){pY1139}{pY1222} (binding) | ErbB3-isoform1(h){pY1289} + Abl(h) <==> ErbB3-isoform1(h){pY1289}:Abl(h) (binding) | ErbB4(h){pY1188} + Abl(h) <==> ErbB4(h){pY1188}:Abl(h) (binding) | Abl(h) + Bcl-X(h) <==> Abl(h):Bcl-X(h) (binding) | Abl(h) + PKCdelta(h) <==> Abl(h):PKCdelta(h) (binding) | Abl(h) + ATP --> Abl(h){pS} + ADP (phosphorylation) | Abl(h) --/ phlpp1(h) (decrease of abundance) | Abl(h) --/ phlpp2(h) (decrease of abundance) | Abl(h) --> AKT-1(h){pS473} (increase of phosphorylation) | Abl(h) --> AKT-2(h){pS474} (increase of phosphorylation) | Abl(h) --> AKT-3(h){p} (increase of phosphorylation) | ABL1(h) --> Abl(h) (expression). | Abl(h) --> Abl(h) (translocation) | p73alpha(mo) + NTP --Abl(h)--> p73alpha(mo){pY99} + NDP (phosphorylation) | p73alpha(h) + ATP --Abl(h)--> p73alpha(h){p} + ADP (phosphorylation) | p73(v.s.) + ATP --Abl(h)--> p73(v.s.){pT}{pY} + ADP (phosphorylation) | Rad9a(h) + ATP --Abl(h)--> Rad9a(h){p} + ADP (phosphorylation) | Rad9a(h) + ATP --Abl(h)--> Rad9a(h){pY28} + ADP (phosphorylation) | TopoI(h) + ATP --Abl(h)--> TopoI(h){pY} + ADP (phosphorylation) | TopoI(h) + ATP --Abl(h)--> TopoI(h){pY268} + ADP (phosphorylation) | IRS-1(m.s.) + ATP --Abl(h)--> IRS-1(m.s.){p} + ADP (phosphorylation) | proCaspase-9(h) + ATP --Abl(h)--> proCaspase-9(h){pY153} + ADP (phosphorylation) | mdm2(h) + ATP --Abl(h)--> mdm2(h){pY276} + ADP (phosphorylation) | PKCdelta(h) + ATP --Abl(h)--> PKCdelta(h){pY311} + ADP (phosphorylation) | ABL-1a(h) + ATP --ATR(m.s.)--> ABL-1a(h){pS446} + ADP (phosphorylation) | ABL1(h) --> ABL-1a(h) (expression). | ABL-1b(h) + ABL-1b(h){pY} <==> ABL-1b(h):ABL-1b(h){pY} (binding) | bcr(h) + ABL-1b(h) <==> bcr(h):ABL-1b(h) (binding) | ABL-1b(h) + acetyl-CoA --p300(m.s.)--> ABL-1b(h){aceK730} + CoA (acetylation) | ABL1(h) --> ABL-1b(h) (expression). | ABL1(h) --> ABL1(h) (expression). | hsa-miR-203 --/ ABL1(h) (translational repression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 185 | Phosphotyrosine. | Swiss-Prot 53.0 | 226 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 253 | Phosphotyrosine. | Swiss-Prot 53.0 | 257 | Phosphotyrosine. | Swiss-Prot 53.0 | 264 | Phosphotyrosine. | Swiss-Prot 53.0 | 393 | Phosphotyrosine (by autocatalysis andSRC-type Tyr-kinases). | Swiss-Prot 53.0 | 394 | Phosphothreonine. | Swiss-Prot 53.0 | 446 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 469 | Phosphotyrosine. | Swiss-Prot 53.0 | 569 | Phosphoserine. | Swiss-Prot 53.0 | 683 | Phosphoserine. | Swiss-Prot 53.0 | 805 | Phosphoserine. | Swiss-Prot 53.0 | 809 | Phosphoserine. | Swiss-Prot 53.0 | 949 | Phosphoserine. | Swiss-Prot 53.0 | 226 | Phosphotyrosine | 10964922;11847100;12522270 | Phospho.ELM 6.0 | 393 | Phosphotyrosine (Abl;Src) | 11781820;10964922;12522270 | Phospho.ELM 6.0 | 185 | Phosphotyrosine | 12522270 | Phospho.ELM 6.0 | 264 | Phosphotyrosine | 12522270 | Phospho.ELM 6.0 | 394 | Phosphothreonine | 12522270 | Phospho.ELM 6.0 | 251 | Phosphotyrosine | 12644574 | Phospho.ELM 6.0 | 283 | Phosphotyrosine | 12644574 | Phospho.ELM 6.0 | 754 | Phosphothreonine | 15696159 | Phospho.ELM 6.0 | 488 | Phosphotyrosine | 16464493 | Phospho.ELM 6.0 | 276 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 272 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 245 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 134 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 204 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 569 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 949 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr9 |
Promoter: 132699152 - 132701152 | Agilent_014791 |
chr9 |
Promoter: 132577589 - 132579589 | Agilent_014791 |
chr9 |
Promoter: 132577589 - 132579589 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 132577589 - 132579589 | GSE27584 |
chr9 |
Promoter: 132699152 - 132701152 | GSE27584 |
chr9 |
Promoter: 132577589 - 132579589 | Agilent_014791_44K |
chr9 |
Promoter: 132699152 - 132701152 | PMID:11559572 |
chr9 |
Promoter: 132577589 - 132579589 | PMID:11559572 |
chr9 |
Promoter: 132699152 - 132701152 | PMID:10498618 |
chr9 |
Promoter: 132577589 - 132579589 | PMID:10498618 |
chr9 |
Promoter: 132699152 - 132701152 | PMID:12114423 |
chr9 |
Promoter: 132577589 - 132579589 | PMID:12114423 |
chr9 |
Promoter: 132699152 - 132701152 | PMID:12548613 |
chr9 |
Promoter: 132577589 - 132579589 | PMID:12548613 |
chr9 |
Promoter: 132699152 - 132701152 | PMID:10779450 |
chr9 |
Promoter: 132577589 - 132579589 | PMID:10779450 |
chr9 |
Promoter: 132699152 - 132701152 | PMID:10068681 |
chr9 |
Promoter: 132577589 - 132579589 | PMID:10068681 |