| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 25 |
Name | ABL1 |
Synonym | ABL|JTK7|bcr/abl|c-ABL|p150|v-abl;c-abl oncogene 1, non-receptor tyrosine kinase;ABL1;c-abl oncogene 1, non-receptor tyrosine kinase |
Definition | Abelson tyrosine-protein kinase 1|bcr/c-abl oncogene protein|c-abl oncogene 1, receptor tyrosine kinase|proto-oncogene c-Abl|proto-oncogene tyrosine-protein kinase ABL1|tyrosine-protein kinase ABL1|v-abl Abelson murine leukemia viral oncogene homolog 1 |
Position | 9q34.1 |
Gene Type | protein-coding |
Pathways and Diseases | |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Axon guidance mediated by Slit/Robo;PANTHER;P00008 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | p53 pathway;PID Curated;200175 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128 |
Pathway | Shigellosis;KEGG PATHWAY;hsa05131 |
Pathway | tumor suppressor arf inhibits ribosomal biogenesis;PID BioCarta;100237 |
Pathway | atm signaling pathway;PID BioCarta;100235 |
Pathway | Regulation of retinoblastoma protein;PID Curated;200191 |
Pathway | Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130 |
Pathway | CDO in myogenesis;PID Reactome;500556 |
Pathway | Lissencephaly gene (LIS1) in neuronal migration and development;PID Curated;200114 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | lissencephaly gene (lis1) in neuronal migration and development;PID BioCarta;100116 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Myogenesis;Reactome;REACT:21303 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Viral myocarditis;KEGG PATHWAY;hsa05416 |
Disease | Eosinophilia;FunDO |
Disease | Cancers;KEGG DISEASE |
Disease | Infection;FunDO |
Disease | Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE |
Disease | CANCER;GAD |
Disease | clonal evolution of chronic myeloid leukemia;GAD |
Disease | Congenital abnormality;FunDO |
Disease | Bone marrow disease;FunDO |
Disease | Cancer;FunDO |
Disease | Bacterial infection;FunDO |
Disease | Chronic myeloid leukemia (CML);KEGG DISEASE;H00004 |
Disease | Acute lymphoblastic leukemia (ALL) (Precursor B lymphoblastic leukemia);KEGG DISEASE;H00001 |
Disease | Alzheimer's disease;FunDO |
Disease | Leukemia, Philadelphia chromosome-positive, resistant to imatinib;OMIM |
External Links | |
Links to Entrez Gene | 25 |
Links to all GeneRIF Items | 25 |
Links to iHOP | 25 |
Sequence Information | |
Nucleotide Sequence | >25 : length: 3393 atgttggagatctgcctgaagctggtgggctgcaaatccaagaaggggctgtcctcgtcc tccagctgttatctggaagaagcccttcagcggccagtagcatctgactttgagcctcag ggtctgagtgaagccgctcgttggaactccaaggaaaaccttctcgctggacccagtgaa aatgaccccaaccttttcgttgcactgtatgattttgtggccagtggagataacactcta agcataactaaaggtgaaaagctccgggtcttaggctataatcacaatggggaatggtgt gaagcccaaaccaaaaatggccaaggctgggtcccaagcaactacatcacgccagtcaac agtctggagaaacactcctggtaccatgggcctgtgtcccgcaatgccgctgagtatctg ctgagcagcgggatcaatggcagcttcttggtgcgtgagagtgagagcagtcctggccag aggtccatctcgctgagatacgaagggagggtgtaccattacaggatcaacactgcttct gatggcaagctctacgtctcctccgagagccgcttcaacaccctggccgagttggttcat catcattcaacggtggccgacgggctcatcaccacgctccattatccagccccaaagcgc aacaagcccactgtctatggtgtgtcccccaactacgacaagtgggagatggaacgcacg gacatcaccatgaagcacaagctgggcgggggccagtacggggaggtgtacgagggcgtg tggaagaaatacagcctgacggtggccgtgaagaccttgaaggaggacaccatggaggtg gaagagttcttgaaagaagctgcagtcatgaaagagatcaaacaccctaacctggtgcag ctccttggggtctgcacccgggagcccccgttctatatcatcactgagttcatgacctac gggaacctcctggactacctgagggagtgcaaccggcaggaggtgaacgccgtggtgctg ctgtacatggccactcagatctcgtcagccatggagtacctggagaagaaaaacttcatc cacagagatcttgctgcccgaaactgcctggtaggggagaaccacttggtgaaggtagct gattttggcctgagcaggttgatgacaggggacacctacacagcccatgctggagccaag ttccccatcaaatggactgcacccgagagcctggcctacaacaagttctccatcaagtcc gacgtctgggcatttggagtattgctttgggaaattgctacctatggcatgtccccttac ccgggaattgacctgtcccaggtgtatgagctgctagagaaggactaccgcatggagcgc ccagaaggctgcccagagaaggtctatgaactcatgcgagcatgttggcagtggaatccc tctgaccggccctcctttgctgaaatccaccaagcctttgaaacaatgttccaggaatcc agtatctcagacgaagtggaaaaggagctggggaaacaaggcgtccgtggggctgtgagt accttgctgcaggccccagagctgcccaccaagacgaggacctccaggagagctgcagag cacagagacaccactgacgtgcctgagatgcctcactccaagggccagggagagagcgat cctctggaccatgagcctgccgtgtctccattgctccctcgaaaagagcgaggtcccccg gagggcggcctgaatgaagatgagcgccttctccccaaagacaaaaagaccaacttgttc agcgccttgatcaagaagaagaagaagacagccccaacccctcccaaacgcagcagctcc ttccgggagatggacggccagccggagcgcagaggggccggcgaggaagagggccgagac atcagcaacggggcactggctttcacccccttggacacagctgacccagccaagtcccca aagcccagcaatggggctggggtccccaatggagccctccgggagtccgggggctcaggc ttccggtctccccacctgtggaagaagtccagcacgctgaccagcagccgcctagccacc ggcgaggaggagggcggtggcagctccagcaagcgcttcctgcgctcttgctccgcctcc tgcgttccccatggggccaaggacacggagtggaggtcagtcacgctgcctcgggacttg cagtccacgggaagacagtttgactcgtccacatttggagggcacaaaagtgagaagccg gctctgcctcggaagagggcaggggagaacaggtctgaccaggtgacccgaggcacagta acgcctccccccaggctggtgaaaaagaatgaggaagctgctgatgaggtcttcaaagac atcatggagtccagcccgggctccagcccgcccaacctgactccaaaacccctccggcgg caggtcaccgtggcccctgcctcgggcctcccccacaaggaagaagctggaaagggcagt gccttagggacccctgctgcagctgagccagtgacccccaccagcaaagcaggctcaggt gcaccagggggcaccagcaagggccccgccgaggagtccagagtgaggaggcacaagcac tcctctgagtcgccagggagggacaaggggaaattgtccaggctcaaacctgccccgccg cccccaccagcagcctctgcagggaaggctggaggaaagccctcgcagagcccgagccag gaggcggccggggaggcagtcctgggcgcaaagacaaaagccacgagtctggttgatgct gtgaacagtgacgctgccaagcccagccagccgggagagggcctcaaaaagcccgtgctc ccggccactccaaagccacagtccgccaagccgtcggggacccccatcagcccagccccc gttccctccacgttgccatcagcatcctcggccctggcaggggaccagccgtcttccacc gccttcatccctctcatatcaacccgagtgtctcttcggaaaacccgccagcctccagag cggatcgccagcggcgccatcaccaagggcgtggtcctggacagcaccgaggcgctgtgc ctcgccatctctaggaactccgagcagatggccagccacagcgcagtgctggaggccggc aaaaacctctacacgttctgcgtgagctatgtggattccatccagcaaatgaggaacaag tttgccttccgagaggccatcaacaaactggagaataatctccgggagcttcagatctgc ccggcgacagcaggcagtggtccagcggccactcaggacttcagcaagctcctcagttcg gtgaaggaaatcagtgacatagtgcagaggtag |
Protein Sequence | >25 : length: 1130 MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSE NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNP SDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAE HRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP KPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSAS CVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTV TPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGS ALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVL PATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPE RIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNK FAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR |