| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 2321 |
Name | FLT1 |
Synonymous | FLT|VEGFR1;fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor);FLT1;fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) |
Definition | FLT-1|VEGFR-1|fms-like tyrosine kinase 1|tyrosine-protein kinase FRT|tyrosine-protein kinase receptor FLT|vascular endothelial growth factor receptor 1|vascular permeability factor receptor |
Position | 13q12 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | VEGFR-1(h) + Sck(m) <==> VEGFR-1(h):Sck(m) (binding) | VEGFR-1(h) + ATP --> VEGFR-1(h){p} (phosphorylation; automodification) | FLT1(h) --> VEGFR-1(h) (expression). | IFNgamma(h) --> VEGFR-1(h) (increase of secretion). | TGFbeta1(m.s.) --> VEGFR-1(h) (increase of secretion) | TGFbeta2(m.s.) --> VEGFR-1(h) (increase of secretion) | FLT1(h) --> VEGFR-1(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 100 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 164 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 196 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 251 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 323 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 402 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 417 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 474 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 547 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 597 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 620 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 625 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 666 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1053 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1169 | Phosphotyrosine (by autocatalysis) (Bysimilarity). | Swiss-Prot 53.0 | 1213 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1242 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1327 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1333 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1242 | Phosphotyrosine (FLT1) | 11513746 | Phospho.ELM 6.0 | 1327 | Phosphotyrosine (FLT1) | 11513746 | Phospho.ELM 6.0 | 1169 | Phosphotyrosine | 11513746;9299537 | Phospho.ELM 6.0 | 794 | Phosphotyrosine | 11741094;9398617 | Phospho.ELM 6.0 | 1333 | Phosphotyrosine (FLT1) | 11513746;9722576;9600074 | Phospho.ELM 6.0 | 1213 | Phosphotyrosine (FLT1) | 11513746;9722576;9600074 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr13 |
Promoter: 27966732 - 27968732 | Agilent_014791 |
chr13 |
Promoter: 27966732 - 27968732 | GoldenGate_Methylation_Cancer_Panel_I |
chr13 |
Promoter: 27966732 - 27968732 | GSE27584 |
chr13 |
Promoter: 27966732 - 27968732 | Agilent_014791_44K |