| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 2321 |
Name | FLT1 |
Synonymous | FLT|VEGFR1;fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor);FLT1;fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) |
Definition | FLT-1|VEGFR-1|fms-like tyrosine kinase 1|tyrosine-protein kinase FRT|tyrosine-protein kinase receptor FLT|vascular endothelial growth factor receptor 1|vascular permeability factor receptor |
Position | 13q12 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for FLT1 | ||
PCGP somatic mutation [Top] | ||
Variant (Variant; Chr; Position) | Genotype (MutationType; MutationClass; ReferenceAllele; Genotype; Origin) | Disease (CancerType; ValidationStatus; SequencingType) |
|---|---|---|
FLT1_L29I; chr13; 29041734 |
SUB; MISSENSE; A; A/T; SOMATIC | LGG; VALID; WGS |
FLT1_T48A; chr13; 29041677 |
SUB; MISSENSE; T; T/C; SOMATIC | LGG; VALID; WGS |
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.1194G>T; p.E398D; |
liver | carcinoma; hepatocellular_carcinoma |
c.2305G>T; p.A769S; |
ovary | other; neoplasm |
c.2221G>A; p.E741K; |
lung | carcinoma; undifferentiated_carcinoma |
c.1767G>A; p.W589*; |
skin; face | malignant_melanoma |
c.3123_3124insT; p.G1042fs*8; 13:27793650-27793651 |
lung | carcinoma; adenocarcinoma |
c.3745C>A; p.L1249M; 13:27778885-27778885 |
lung | carcinoma; adenocarcinoma |
c.3074C>A; p.A1025E; 13:27793700-27793700 |
lung | carcinoma; adenocarcinoma |
c.601G>C; p.E201Q; 13:27906270-27906270 |
lung | carcinoma; adenocarcinoma |
c.1634G>A; p.G545E; |
skin; neck | malignant_melanoma |
c.3154G>A; p.D1052N; |
NS | malignant_melanoma |
c.3154G>A; p.D1052N; |
NS | malignant_melanoma |
c.1552-9C>A; p.?; |
skin; shoulder | malignant_melanoma |
c.2827G>A; p.E943K; |
skin; nipple | malignant_melanoma |
c.1925A>G; p.Y642C; |
liver | carcinoma; hepatocellular_carcinoma |
c.1294G>A; p.E432K; |
NS | malignant_melanoma |
c.1294G>A; p.E432K; |
NS | malignant_melanoma |
c.842G>A; p.R281Q; |
skin; neck | malignant_melanoma |
c.2440C>T; p.P814S; |
skin; face | malignant_melanoma |
c.2827G>A; p.E943K; |
skin; back | malignant_melanoma |
c.3779G>T; p.W1260L; |
lung | carcinoma; small_cell_carcinoma |
c.3778T>C; p.W1260R; |
lung | carcinoma; small_cell_carcinoma |
c.2269C>G; p.L757V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3770G>A; p.R1257H; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1616A>C; p.N539T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.547C>T; p.R183C; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3241G>A; p.D1081N; |
skin; back | malignant_melanoma |
c.860C>T; p.S287F; |
skin; knee | malignant_melanoma |
c.3667G>A; p.E1223K; |
skin; chest | malignant_melanoma |
c.477G>T; p.R159R; |
lung | carcinoma; adenocarcinoma |
c.1404G>T; p.W468C; |
lung | carcinoma; adenocarcinoma |
c.3175-1G>A; p.?; |
lung | carcinoma; adenocarcinoma |
c.3421C>A; p.P1141T; |
stomach | carcinoma; intestinal_adenocarcinoma |
c.983T>C; p.I328T; |
liver | carcinoma |
c.2576C>T; p.A859V; |
liver | carcinoma |
c.1281A>T; p.K427N; 13:27899451-27899451 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.2453G>A; p.S818N; 13:27811340-27811340 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.1842G>A; p.E614E; |
large_intestine | carcinoma; adenocarcinoma |
c.1437-6delt; p.?; |
large_intestine | carcinoma; adenocarcinoma |
c.1039G>A; p.V347I; |
large_intestine | carcinoma; adenocarcinoma |
c.1437-6delt; p.?; |
large_intestine | carcinoma; adenocarcinoma |
c.1825delA; p.M609fs*16; |
large_intestine | carcinoma; adenocarcinoma |
c.3732C>T; p.G1244G; |
large_intestine | carcinoma; adenocarcinoma |
c.3259G>A; p.V1087I; |
large_intestine | carcinoma; adenocarcinoma |
c.1437-7_1437-6deltt; p.?; |
large_intestine | carcinoma; adenocarcinoma |
c.1437-6_1437-5insT; p.?; |
large_intestine | carcinoma; adenocarcinoma |
c.3721-4_3721-3insC; p.?; |
large_intestine | carcinoma; adenocarcinoma |
c.838C>T; p.R280*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1408C>T; p.P470S; |
large_intestine | carcinoma; adenocarcinoma |
c.838C>T; p.R280*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1747delT; p.L583fs*42; |
prostate | carcinoma; adenocarcinoma |
c.3718G>C; p.D1240H; |
oesophagus | carcinoma; adenocarcinoma |
c.3954C>T; p.I1318I; |
oesophagus | carcinoma; adenocarcinoma |
c.482C>T; p.T161M; |
oesophagus | carcinoma; adenocarcinoma |
c.1492A>G; p.M498V; |
oesophagus | carcinoma; squamous_cell_carcinoma |
c.1787A>G; p.N596S; |
lung | carcinoma; small_cell_carcinoma |
c.935G>A; p.R312H; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2065G>T; p.E689*; |
upper_aerodigestive_tract; larynx | carcinoma; squamous_cell_carcinoma |
c.3053G>A; p.C1018Y; |
breast | carcinoma |
c.3181C>G; p.L1061V; 13:27791665-27791665 |
urinary_tract; bladder | carcinoma |
c.2155G>C; p.E719Q; |
lung | carcinoma; adenocarcinoma |
c.1540G>A; p.G514R; |
lung | carcinoma; adenocarcinoma |
c.476G>A; p.R159Q; |
lung | carcinoma; adenocarcinoma |
c.1969G>C; p.D657H; |
lung | carcinoma; adenocarcinoma |
c.1232A>T; p.Q411L; |
lung | carcinoma; adenocarcinoma |
c.2364T>A; p.S788S; |
lung | carcinoma; adenocarcinoma |
c.365C>A; p.S122Y; |
lung | carcinoma; adenocarcinoma |
c.2797G>A; p.D933N; |
lung | carcinoma; adenocarcinoma |
c.3460C>G; p.L1154V; |
lung | carcinoma; adenocarcinoma |
c.1203G>A; p.G401G; |
lung | carcinoma; adenocarcinoma |
c.780G>C; p.T260T; |
lung | carcinoma; adenocarcinoma |
c.2043C>A; p.D681E; |
lung | carcinoma; adenocarcinoma |
c.187T>A; p.L63M; |
lung | carcinoma; adenocarcinoma |
c.2644T>C; p.L882L; |
lung | carcinoma; adenocarcinoma |
c.2071C>A; p.Q691K; |
lung | carcinoma; adenocarcinoma |
c.512delA; p.K171fs*7; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2342G>A; p.R781Q; 13:27817595-27817595 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; hairy_cell_leukaemia |
c.2342G>A; p.R781Q; 13:27817595-27817595 |
breast | carcinoma |
c.2342G>A; p.R781Q; 13:27817595-27817595 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; hairy_cell_leukaemia |
c.2342G>A; p.R781Q; 13:27817595-27817595 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; myelodysplastic_syndrome |
c.941G>A; p.R314K; |
skin; trunk | malignant_melanoma |
c.401C>T; p.P134L; |
NS | malignant_melanoma |
c.1459G>A; p.E487K; |
skin; extremity | malignant_melanoma |
c.2255C>T; p.S752L; |
stomach | carcinoma |
c.2022C>A; p.I674I; 13:27857116-27857116 |
lung | carcinoma; small_cell_carcinoma |
c.2580G>T; p.V860V; 13:27806175-27806175 |
breast | carcinoma; lobular_carcinoma |
c.1264C>A; p.L422I; 13:27899901-27899901 |
lung | carcinoma; adenocarcinoma |
c.2342G>A; p.R781Q; 13:27817595-27817595 |
central_nervous_system; brain | glioma |
c.1552-5T>C; p.?; |
liver | carcinoma |
c.813+1G>T; p.?; |
liver | carcinoma |
c.581T>C; p.I194T; |
liver | carcinoma |
c.3552C>T; p.Y1184Y; |
skin | carcinoma |
c.2561C>T; p.T854M; |
large_intestine | carcinoma; adenocarcinoma |
c.1305G>T; p.V435V; |
lung | carcinoma; small_cell_carcinoma |
c.1921G>T; p.V641L; |
lung | carcinoma; small_cell_carcinoma |
c.1038C>G; p.T346T; |
lung | carcinoma; small_cell_carcinoma |
c.1071G>T; p.M357I; |
lung | carcinoma; small_cell_carcinoma |
c.1385C>T; p.P462L; |
breast | carcinoma; basal_(triple-negative)_carcinoma |
c.1993C>T; p.R665*; |
large_intestine; colon | adenoma |
c.142A>G; p.T48A; |
NS | NS |
c.142A>C; p.T48P; |
NS | NS |
c.85T>A; p.L29I; |
NS | NS |
c.536C>G; p.P179R; 13:27906335-27906335 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.1818G>T; p.K606N; |
lung | carcinoma; adenocarcinoma |
c.1202G>A; p.G401E; |
lung | carcinoma; adenocarcinoma |
c.2179G>T; p.G727C; 13:27829760-27829760 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.636T>A; p.N212K; 13:27906235-27906235 |
ovary | carcinoma; serous_carcinoma |
c.1468T>C; p.F490L; 13:27878000-27878000 |
ovary | carcinoma; serous_carcinoma |
c.3794C>A; p.P1265H; |
lung | carcinoma; squamous_cell_carcinoma |
c.2435G>A; p.R812Q; |
ovary | carcinoma; serous_carcinoma |
c.2311C>A; p.L771I; |
lung | carcinoma; squamous_cell_carcinoma |
c.814-2A>G; p.?; |
lung | carcinoma; adenocarcinoma |
c.3211A>T; p.I1071F; |
lung | carcinoma; squamous_cell_carcinoma |
c.617C>A; p.T206N; |
lung | carcinoma; adenocarcinoma |
c.3924C>A; p.T1308T; |
lung | carcinoma; adenocarcinoma |
c.2873A>G; p.D958G; |
lung | carcinoma; squamous_cell_carcinoma |
c.3240C>A; p.S1080R; |
lung | carcinoma; adenocarcinoma |
c.506T>C; p.L169S; |
lung | carcinoma; adenocarcinoma |
c.2320C>A; p.L774I; |
lung | carcinoma; squamous_cell_carcinoma |
c.197T>C; p.M66T; |
lung | carcinoma; adenocarcinoma |
c.527C>T; p.T176I; |
lung | carcinoma; adenocarcinoma |
c.712C>A; p.R238S; |
lung | carcinoma; adenocarcinoma |
c.637G>T; p.G213W; |
lung; right_lower_lobe | carcinoma; adenocarcinoma |
c.3567C>T; p.F1189F; |
lung; right_lower_lobe | carcinoma; adenocarcinoma |
c.3265C>T; p.L1089L; |
lung | carcinoma; adenocarcinoma |
c.1183G>C; p.V395L; |
lung | carcinoma; adenocarcinoma |
c.3752C>A; p.A1251D; |
lung | carcinoma; adenocarcinoma |
c.3237G>T; p.K1079N; |
lung; middle_lobe | carcinoma; adenocarcinoma |
c.1777C>T; p.R593W; |
lung | carcinoma; adenocarcinoma |
c.1811T>C; p.I604T; |
lung | carcinoma; adenocarcinoma |
c.1066T>C; p.S356P; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.3706A>T; p.T1236S; |
lung; right_lower_lobe | carcinoma; adenocarcinoma |
c.1095G>A; p.P365P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3987G>A; p.S1329S; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.2342G>A; p.R781Q; 13:27817595-27817595 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2181T>C; p.G727G; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1703C>T; p.T568M; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1551G>A; p.K517K; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.2878G>A; p.V960I; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1474C>G; p.L492V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3603G>A; p.P1201P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2604G>A; p.T868T; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.593C>T; p.T198M; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.713G>A; p.R238H; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1301C>T; p.A434V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3904G>A; p.E1302K; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2067G>A; p.E689E; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3164G>A; p.R1055K; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.3955G>A; p.A1319T; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.212G>T; p.S71I; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3969G>A; p.P1323P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2620G>A; p.A874T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1284C>G; p.P428P; |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia |
c.3761T>C; p.M1254T; |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia |
c.3244G>A; p.V1082M; |
large_intestine; rectum | NS |
c.1265T>C; p.L422P; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1700C>T; p.P567L; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.214G>A; p.E72K; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.2041G>T; p.D681Y; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.2782T>G; p.F928V; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.2670C>T; p.N890N; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1183G>A; p.V395I; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.593C>T; p.T198M; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3019G>A; p.A1007T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3816-1G>A; p.?; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2095C>T; p.H699Y; |
endometrium | carcinoma; endometrioid_carcinoma |
c.153C>A; p.L51L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1015C>T; p.R339*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3040T>C; p.S1014P; |
breast | carcinoma |
c.1280A>G; p.K427R; |
large_intestine | carcinoma; adenocarcinoma |
c.3437G>T; p.R1146I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.348G>T; p.K116N; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2134G>T; p.G712*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1310C>T; p.S437L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.195A>G; p.E65E; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2604G>A; p.T868T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1813A>G; p.S605G; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3440T>G; p.F1147C; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1960A>G; p.T654A; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.430G>A; p.E144K; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.3655T>A; p.F1219I; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1280A>G; p.K427R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.634A>G; p.N212D; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.2179G>T; p.G727C; 13:27829760-27829760 |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.2341C>A; p.R781R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2384T>A; p.L795Q; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1147T>C; p.Y383H; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1372G>A; p.G458S; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.731G>T; p.R244I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2307G>A; p.A769A; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2306C>T; p.A769V; |
endometrium | carcinoma; endometrioid_carcinoma |
c.876C>G; p.F292L; |
breast | carcinoma |
c.989-2A>C; p.?; |
endometrium | carcinoma; endometrioid_carcinoma |
c.176A>G; p.H59R; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2859G>A; p.K953K; |
urinary_tract; bladder | carcinoma |
c.831C>T; p.S277S; |
breast | carcinoma |
c.1265T>C; p.L422P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3810G>T; p.K1270N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.811G>T; p.E271*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.634A>G; p.N212D; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2473G>T; p.E825*; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.2021T>C; p.I674T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.537T>C; p.P179P; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.535C>T; p.P179S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3898G>A; p.V1300I; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2021T>C; p.I674T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2341C>A; p.R781R; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3368A>G; p.E1123G; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2916G>T; p.Q972H; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3780G>T; p.W1260C; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2657G>A; p.G886D; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2952G>T; p.E984D; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1429G>A; p.E477K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3175-1G>A; p.?; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3334C>T; p.R1112C; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1264C>T; p.L422L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2910C>T; p.G970G; |
endometrium | carcinoma; endometrioid_carcinoma |
c.663C>G; p.L221L; |
urinary_tract; bladder | carcinoma |
c.1469T>C; p.F490S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1279A>G; p.K427E; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1265T>C; p.L422P; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1265T>C; p.L422P; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.3898G>A; p.V1300I; |
prostate | carcinoma; adenocarcinoma |
c.2452A>G; p.S818G; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1469T>C; p.F490S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3075G>T; p.A1025A; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.3182T>C; p.L1061P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2341C>A; p.R781R; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.818delA; p.N273fs*6; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1264C>T; p.L422L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2181T>C; p.G727G; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1526T>C; p.M509T; |
stomach | carcinoma |
c.259C>T; p.Q87*; |
prostate | carcinoma |
c.164G>T; p.G55V; |
skin; acral | malignant_melanoma |
c.2504G>A; p.R835K; |
skin | malignant_melanoma |
c.2377G>A; p.D793N; |
skin | malignant_melanoma |
c.2342G>A; p.R781Q; 13:27817595-27817595 |
skin | malignant_melanoma |
c.3721-1G>A; p.?; |
skin | malignant_melanoma |
c.2144C>T; p.T715M; |
skin | malignant_melanoma |
c.1220T>G; p.L407R; |
skin | malignant_melanoma |
c.671G>A; p.R224Q; |
skin | malignant_melanoma |
c.2159G>A; p.R720K; |
skin | malignant_melanoma |
c.1071G>A; p.M357I; |
skin | malignant_melanoma |
c.2342G>A; p.R781Q; 13:27817595-27817595 |
skin | malignant_melanoma |
c.3031G>A; p.E1011K; |
skin; neck | malignant_melanoma |
c.2744G>A; p.G915E; |
skin | malignant_melanoma |
c.2788C>T; p.L930F; |
skin | malignant_melanoma |
c.3660G>T; p.M1220I; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1167G>A; p.S389S; |
stomach | adenocarcinoma |