Entrez Gene

Basic Information
Gene ID	22974
Name	TPX2
Synonymous	C20orf1\|C20orf2\|DIL-2\|DIL2\|FLS353\|GD:C20orf1\|HCA519\|HCTP4\|REPP86\|p100;TPX2, microtubule-associated, homolog (Xenopus laevis);TPX2;TPX2, microtubule-associated, homolog (Xenopus laevis)
Definition	TPX2, microtubule-associated protein homolog\|differentially expressed in cancerous and non-cancerous lung cells 2\|differentially expressed in lung cells\|hepatocellular carcinoma-associated antigen 519\|preferentially expressed in colorectal cancer\|protein
Position	20q11.2
Gene Type	protein-coding
Gene Regulation:	Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database

Regulation From TransFac database
Transcription Factors [Top]
TPX2(h) + Aurora-A(h) <==> TPX2(h):Aurora-A(h) (binding)
TPX2(h) + ATP --Aurora-A(h){p}--> TPX2(h){pS} + ADP (phosphorylation)
importin-beta(h) + TPX2(h) <==> importin-beta(h):TPX2(h) (binding)
TPX2(h) + Fzr1(h) <==> TPX2(h):Fzr1(h) (binding)
Tpx2(h) --> TPX2(h) (expression).
TPX2(h) + n ubiquitin(h) --E2-C(h),cyclosome(x):Fzr1(h)--> TPX2(h){ub}n (ubiquitination)
Tpx2(h) --> TPX2(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Translational Modification [Top]
51	Phosphothreonine.		Swiss-Prot 53.0
72	Phosphothreonine.		Swiss-Prot 53.0
121	Phosphoserine.		Swiss-Prot 53.0
125	Phosphoserine.		Swiss-Prot 53.0
147	Phosphothreonine.		Swiss-Prot 53.0
186	Phosphoserine.		Swiss-Prot 53.0
293	Phosphoserine.		Swiss-Prot 53.0
338	Phosphothreonine.		Swiss-Prot 53.0
359	Phosphoserine.		Swiss-Prot 53.0
369	Phosphothreonine.		Swiss-Prot 53.0
374	Phosphothreonine.		Swiss-Prot 53.0
486	Phosphoserine.		Swiss-Prot 53.0
542	Phosphoserine.		Swiss-Prot 53.0
652	Phosphoserine.		Swiss-Prot 53.0
654	Phosphoserine.		Swiss-Prot 53.0
738	Phosphoserine.		Swiss-Prot 53.0
738	Phosphoserine	15302935	Phospho.ELM 6.0
121	Phosphoserine	16565220	Phospho.ELM 6.0
125	Phosphoserine	16565220	Phospho.ELM 6.0
147	Phosphothreonine	16565220	Phospho.ELM 6.0
186	Phosphoserine	16565220	Phospho.ELM 6.0
293	Phosphoserine	16565220	Phospho.ELM 6.0
338	Phosphothreonine	16565220	Phospho.ELM 6.0
359	Phosphoserine	16565220	Phospho.ELM 6.0
369	Phosphothreonine	16565220	Phospho.ELM 6.0
374	Phosphothreonine	16565220	Phospho.ELM 6.0
486	Phosphoserine	16565220	Phospho.ELM 6.0
51	Phosphothreonine	16565220	Phospho.ELM 6.0
542	Phosphoserine	16565220	Phospho.ELM 6.0
652	Phosphoserine	16565220	Phospho.ELM 6.0
654	Phosphoserine	16565220	Phospho.ELM 6.0
72	Phosphothreonine	16565220	Phospho.ELM 6.0

Transcription Factors [Top]