| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 2065 |
Name | ERBB3 |
Synonymous | ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3;v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian);ERBB3;v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) |
Definition | proto-oncogene-like protein c-ErbB-3|receptor tyrosine-protein kinase erbB-3|tyrosine kinase-type cell surface receptor HER3 |
Position | 12q13 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | Nrdp1(m) + ErbB3(h) <==> Nrdp1(m):ErbB3(h) (binding) | ErbB3(h) + ubiquitin(v.s.) --Nrdp1(m)--> ErbB3(h){ub} (ubiquitination) | ErbB3(h) + ubiquitin(v.s.) --E1(h),Ubc5C(h),Nrdp1(m)--> ErbB3(h){ub} (ubiquitination) | ErbB3(h) + ATP --> ErbB3(h){pY} + ADP (phosphorylation) | Shc-1(h) + ErbB3(h) <==> Shc-1(h):ErbB3(h) (binding) | ErbB3(h) + p85(h) <==> ErbB3(h):p85(h) (binding) | ErbB3(h) + ErbB2(h) <==> ErbB3(h):ErbB2(h) (binding) | ErbB3(h) + MUC4(m.s.):ErbB2(h) <==> ErbB2(h):ErbB3(h):MUC4(m.s.) (binding) | LRIG1-xbb1(h) + ErbB3(h) <==> LRIG1-xbb1(h):ErbB3(h) (binding) | gp130(h) + ErbB3(h) <==> gp130(h):ErbB3(h) (binding) | ErbB3(h) + ATP --> ErbB3(h){pY1289} + ADP (phosphorylation) | muc1(h) + ErbB3(h) <==> muc1(h):ErbB3(h) (binding) | ErbB3(h) + ErbB2(h){pY1248} <==> ErbB3(h):ErbB2(h){pY1248} (binding) | Ebp1(m.s.) + ErbB3(h) <==> Ebp1(m.s.):ErbB3(h) (binding) | ErbB3(h) + p85alpha(h) <==> ErbB3(h):p85alpha(h) (binding) | ErbB1(h) + ErbB3(h) <==> ErbB1(h):ErbB3(h) (binding) | ErbB4(h) + ErbB3(h) <==> ErbB4(h):ErbB3(h) (binding) | ErbB3(h) + p85(h){pY} <==> ErbB3(h):p85(h){pY} (binding) | ErbB2(m.s.) + ErbB3(h) <==> ErbB2(m.s.):ErbB3(h) (binding) | ErbB3(h) + ATP --> ErbB3(h){pY} + ADP (phosphorylation; automodification) | E-cadherin-ECD(h) + ErbB3(h) + ErbB2(h) <==> E-cadherin-ECD(h):ErbB3(h):ErbB2(h) (binding) | HPRG(m.s.) + ErbB3(h) <==> HPRG(m.s.):ErbB3(h) (binding) | ErbB3(h) + Nrdp1(m.s.) <==> ErbB3(h):Nrdp1(m.s.) (binding) | ERBB3(h) --> ErbB3(h) (expression). | tec(h) + ErbB3-isoform1(h) <==> tec(h):ErbB3-isoform1(h) (binding) | Blk(h) + ErbB3-isoform1(h) <==> Blk(h):ErbB3-isoform1(h) (binding) | ErbB3-isoform1(h) + Grap2(h) <==> ErbB3-isoform1(h):Grap2(h) (binding) | ErbB3-isoform1(h) + Jak1(h) <==> ErbB3-isoform1(h):Jak1(h) (binding) | ErbB3-isoform1(h) + STAT3(h) <==> ErbB3-isoform1(h):STAT3(h) (binding) | ErbB3-isoform1(h) + STAT4(h) <==> ErbB3-isoform1(h):STAT4(h) (binding) | ErbB3-isoform1(h) + STAT5A(h) <==> ErbB3-isoform1(h):STAT5A(h) (binding) | ErbB3-isoform1(h) + STAT6(h) <==> ErbB3-isoform1(h):STAT6(h) (binding) | ErbB3-isoform1(h) + SOCS-2(h) <==> ErbB3-isoform1(h):SOCS-2(h) (binding) | ErbB3-isoform1(h) + SOCS-1(h) <==> ErbB3-isoform1(h):SOCS-1(h) (binding) | ErbB3-isoform1(h) + RIN2(h) <==> ErbB3-isoform1(h):RIN2(h) (binding) | ErbB3-isoform1(h) + NSP1(h) <==> ErbB3-isoform1(h):NSP1(h) (binding) | ErbB3-isoform1(h) + RHOGAP2(h) <==> ErbB3-isoform1(h):RHOGAP2(h) (binding) | ErbB3-isoform1(h) + VRAP(h) <==> ErbB3-isoform1(h):VRAP(h) (binding) | ErbB3-isoform1(h) + JIP-2(h) <==> ErbB3-isoform1(h):JIP-2(h) (binding) | ErbB3-isoform1(h) + 11 ATP --ErbB1-p170(h)--> ErbB3-isoform1(h){pY1054}{pY1159}{pY1197}{pY1199}{pY1222}{pY1224}{pY1260}{pY1262}{pY1276}{pY1289}{pY1328} + 11 ADP (phosphorylation) | ErbB3-isoform1(h) + ATP --ErbB2(h)--> ErbB3-isoform1(h){pY} + ADP (phosphorylation) | ErbB3-isoform1(h) + ErbB2(h) <==> ErbB3-isoform1(h):ErbB2(h) (binding) | ERBB3(h) --> ErbB3-isoform1(h) (expression). | ERBB3(h) --> ErbB3-isoform2(h) (expression). | ERBB3(h) --> ErbB3(h) (expression). | hsa-miR-125b --/ ErbB3(h) (increase of mRNA decay). | hsa-miR-125a --/ ErbB3(h) (increase of mRNA decay). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 126 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 250 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 353 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 408 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 414 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 437 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 469 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 522 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 566 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 616 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 1276 | Phosphotyrosine | 11546794 | Phospho.ELM 6.0 | 1289 | Phosphotyrosine | 11546794 | Phospho.ELM 6.0 | 1262 | Phosphotyrosine | 9516479 | Phospho.ELM 6.0 | 1199 | Phosphotyrosine | 9516479 | Phospho.ELM 6.0 | 1328 | Phosphotyrosine | 9694850 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr12 |
Promoter: 54758659 - 54760659 | Agilent_014791 |
chr12 |
Promoter: 54758659 - 54760659 | GoldenGate_Methylation_Cancer_Panel_I |
chr12 |
Promoter: 54758659 - 54760659 | GoldenGate_Methylation_Cancer_Panel_I |
chr12 |
Promoter: 54758659 - 54760659 | GSE27584 |
chr12 |
Promoter: 54758659 - 54760659 | GSE27584 |
chr12 |
Promoter: 54758659 - 54760659 | Agilent_014791_44K |