| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 1385 |
Name | CREB1 |
Synonymous | CREB;cAMP responsive element binding protein 1;CREB1;cAMP responsive element binding protein 1 |
Definition | CREB-1|active transcription factor CREB|cAMP-response element-binding protein-1|cAMP-responsive element-binding protein 1|cyclic AMP-responsive element-binding protein 1|transactivator protein |
Position | 2q34 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Translational Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | CREB(h) + ATP --MAPKAPK2(r){p}--> CREB(h){p} + ADP (phosphorylation) | CREB(h) + ATP --RSK1(r){p}--> CREB(h){p} + ADP (phosphorylation) | CREB(h) + ATP --RSK2(r){p}--> CREB(h){p} + ADP (phosphorylation) | CREB(h) + ATP --RSK3(r){p}--> CREB(h){p} + ADP (phosphorylation) | CREB(h) + ATP --RSK3(h){p}--> CREB(h){p} + ADP (phosphorylation) | CREB(h) --> E1A(AD5) (DNA binding). | CREB(h) --> EIIaE1(AD) (DNA binding). | CREB(h) --> E3(AD) (DNA binding; transregulation). | CREB(h) --> E4(AD) (DNA binding). | CREB(h) --> FN1(h) (DNA binding). | CREB(h) --> FOS(h) (DNA binding; transactivation). | CREB(h) --> Fos(m) (DNA binding). | CREB(h) --> CGA(h) (DNA binding). | CREB(h) --> HTLV-I(HT1) (DNA binding; transregulation). | CREB(h) --> Ldha(m) (DNA binding). | CREB(h) --> H-2Kb(m) (DNA binding). | CREB(h) --> Pck1(r) (DNA binding). | CREB(h) --> Sst(r) (DNA binding). | CREB(h) --> RNU4C(h) (DNA binding). | CREB(h) --> VIP(h) (DNA binding). | CREB(h) --> Cck(r) (DNA binding; transregulation). | CREB(h) --> INS(h) (DNA binding). | CREB(h) --> ADRB2(h) (DNA binding). | CREB(h) --> PTH(h) (DNA binding). | CREB(h) --> tPA(h) (DNA binding). | CREB(h) --> HBV enhancer(HBV) (DNA binding). | CREB(h) --> CCNA2(h) (DNA binding). | CREB(h) --> CFTR(h) (DNA binding). | CREB(h) --> Plat(m) (DNA binding). | CREB(h) --> tPA(r) (DNA binding). | CREB(h) --> QM(h) (DNA binding). | CREB(h) --> DBH(h) (DNA binding). | CREB(h) --> TH(r) (DNA binding). | ATF(h) + CREB(h) <==> ATF(h):CREB(h) (binding). | CREB(h) + CBP(m) <==> CREB(h):CBP(m) (binding). | CREB(h) + CBP(h) <==> CREB(h):CBP(h) (binding). | p300(h) + CREB(h) <==> p300(h):CREB(h) (binding). | deltaCREB(h) + CREB(h) <==> deltaCREB(h):CREB(h) (binding). | CREB(h) + Tax(HT1) <==> CREB(h):Tax(HT1) (binding). | CREB(h) + ATF-1(m) <==> CREB(h):ATF-1(m) (binding). | CREB(h) + CBP100(m) <==> CREB(h):CBP100(m) (binding). | CREB(h) + CREMalpha(m) <==> CREB(h):CREMalpha(m) (binding). | CREB(h) + ICER(r) <==> CREB(h):ICER(r) (binding). | CREB(h) + deltaCREB(mv) <==> CREB(h):deltaCREB(mv) (binding). | CREB(h) + pX(HBV) <==> CREB(h):pX(HBV) (binding). | deltaCREB(r) + CREB(h) <==> deltaCREB(r):CREB(h) (binding). | deltaCREB(m) + CREB(h) <==> deltaCREB(m):CREB(h) (binding). | CREB(h) --> IGFBP1(h) (DNA binding; transactivation). | CREB(h) + ATP --RSK2(h)--> CREB(h){p} + ADP (phosphorylation) | CREB(h) --> CCND1(h) (DNA binding). | CREB(h) --> HLA-DRA(h) (DNA binding). | CREB(h) --> HLA-DPB(h) (DNA binding). | CREB(h) --> HLA-DRB(h) (DNA binding). | CREB(h) --> SP-B(rb) (DNA binding). | CREB(h) + CREB(h) <==> CREB(h):CREB(h) (binding). | CREB(h) + ATF-1(h) <==> CREB(h):ATF-1(h) (binding). | CREB(h) --> Stat3(m) (DNA binding; transactivation). | CREB(h) --> CCL5(h) (DNA binding; transactivation). | CREB(h) --> BDNF(h) (DNA binding; transactivation). | CREB(h) --> LOR(h) (DNA binding; transactivation). | CREB(h) --> TCR-Vbeta 8.1(h) (DNA binding; transactivation). | CREB(h) --Caspase-3(h)--> CREB-p30(h) + protein remnants (processing) | CREB(h) --> MITF(h) (DNA binding; transactivation). | CREB(h) --> PSEN1(h) (DNA binding; transactivation). | CREB(h) --> CRH(h) (DNA binding; transactivation). | CREB(h) --> TRH(h) (DNA binding; transactivation). | CREB(h) --> Junb(m) (DNA binding; transactivation). | CREB(h) --> EGR1(h) (DNA binding). | CREB(h) --> SLC25A3(h) (DNA binding; transactivation). | TORC1(h) + CREB(h) <==> CREB(h):TORC1(h) (binding) | TORC2(h) + CREB(h) <==> CREB(h):TORC2(h) (binding) | CREB(h) --> MIRN132(h) (DNA binding; transactivation) | CREB(h) + ATP --ATR(m.s.)--> CREB(h){p} + ADP (phosphorylation) | CREB(h) + ATP --> CREB(h){pS121} + ADP (phosphorylation) | CREB(h) + 3 ATP --ATM(h)--> CREB(h){pT100}{pS111}{pS121} + 3 ADP (phosphorylation) | CREB(h) + ATP --ATM(m.s.)--> CREB(h){p} + ADP (phosphorylation) | CBP(m.s.) + CREB(h) <==> CBP(m.s.):CREB(h) (binding) | CREB(h) --> Gch1(r) (DNA binding). | CREB(h) --> SYN1(h) (DNA binding). | CREB(h) --> Scg2(m) (DNA binding). | CREB(h) --> ST8SIA1(h) (DNA binding). | CREB(h) --> Chgb(m) (DNA binding). | CREB1(h) --> CREB(h) (expression). | deltaCREB(h) --> E4(AD) (DNA binding). | deltaCREB(h) + ATF(h) <==> deltaCREB(h):ATF(h) (binding). | deltaCREB(h) + CREB(h) <==> deltaCREB(h):CREB(h) (binding). | deltaCREB(h) + CREB1(r) <==> deltaCREB(h):CREB1(r) (binding). | deltaCREB(h) + CREB(m) <==> deltaCREB(h):CREB(m) (binding). | CREB(pg) + deltaCREB(h) <==> CREB(pg):deltaCREB(h) (binding). | deltaCREB(h) + ATF-1(m) <==> deltaCREB(h):ATF-1(m) (binding). | deltaCREB(h) + CREB(HA) <==> deltaCREB(h):CREB(HA) (binding). | deltaCREB(h) + CREB(mv) <==> deltaCREB(h):CREB(mv) (binding). | deltaCREB(h) + CREB1(b) <==> deltaCREB(h):CREB1(b) (binding). | deltaCREB(h) + deltaCREB(h) <==> deltaCREB(h):deltaCREB(h) (binding). | deltaCREB(h) + ATF-1(h) <==> deltaCREB(h):ATF-1(h) (binding). | deltaCREB(h) --> Cryaa(m) (DNA binding). | CREB1(h) --> deltaCREB(h) (expression). | CREB1(h) + ATP --> CREB1(h){p} + ADP (phosphorylation) | CREB1(h) --> c-Fos(m) (increase of promoter activity) | CREB1(h) --> CXCR4(h) (DNA binding) | CREB1(h) --> AREG(h) (DNA binding) | CKII-alpha(h) + CREB1(h) <==> CKII-alpha(h):CREB1(h) (binding) | CREB1(h) + ATP --> CREB1(h){pS133} + ADP (phosphorylation) | CREB1(h) --> Fos(m) (transactivation) | CREB1(h) + topoisomerase-II-alpha(h) <==> topoisomerase-II-alpha(h):CREB1(h) (binding) | c-Ets-2(h) + CREB1(h) <==> c-Ets-2(h):CREB1(h) (binding) | ATF-1(h) + CREB1(h) <==> ATF-1(h):CREB1(h) (binding) | CREB1(h) + CREM-Ia(h) <==> CREB1(h):CREM-Ia(h) (binding) | CREB1(h) + ICER-xbb1(h) <==> CREB1(h):ICER-xbb1(h) (binding) | CREB1(h) + CREM-Ib(h) <==> CREB1(h):CREM-Ib(h) (binding) | 2 CREB1(h) <==> (CREB1(h))2 (oligomerization) | E4BP4(h) + CREB1(h) <==> E4BP4(h):CREB1(h) (binding) | CREB1(h) --> KIR3DL1(h) (DNA binding). | CREB1(h) --> FOS(h) (DNA binding). | CREB1(h) --> GNRHR(h) (DNA binding; transactivation). | CBP(h) + CREB1(h) <==> CBP(h):CREB1(h) (binding) | CREB1(h) + ATP --ATM(h)--> CREB1(h){pS121} + ADP (phosphorylation) | CREB1(h) + ATP --> CREB1(h){pS121} + ADP (phosphorylation) | CREB1(h) --> SOX9(h) (DNA binding; transactivation). | CREB1(h) --> PSENEN(h) (DNA binding). | CREB1(h) --> CD1A(h) (DNA binding). | CREB1(h) --> BRCA1(h) (DNA binding). | CREB1(h) --> TPT1(h) (DNA binding). | CREB1(h) --> NR4A2(h) (DNA binding). | CREB1(h) --> TH(r) (DNA binding). | CREB1(h) --> CDC2L2(h) (DNA binding). | CREB1(h) --> EXO1(h) (DNA binding). | CREB1(h) --> PBK(h) (DNA binding). | CREB1(h) --> ZNF268(h) (DNA binding). | CREB1(h) --> CYP19A1(h) (DNA binding). | CREB1(h) --> IER2(h) (DNA binding). | POU2F1(h) + CREB1(h) <==> POU2F1(h):CREB1(h) (binding) | CREB1(h) --> TNF(h) (DNA binding). | CREB1(h) --> CCND1(h) (DNA binding). | CREB1(h) --> BCL2L1(h) (DNA binding). | CREB1(h) --> ID1(h) (DNA binding). | CREB1(h) --> DSIPI(h) (DNA binding). | CREB1(h) --> Ldha(r) (DNA binding). | CREB1(h) --> Chga(m) (transactivation) | CREB1(h) + ATF-2(h) <==> CREB1(h):ATF-2(h) (binding) | c-Jun(h) + CREB1(h) <==> c-Jun(h):CREB1(h) (binding) | CREB1(h) --> IFNG(h) (DNA binding). | CREB1(h) --> EGR1(h) (DNA binding). | CREB1(h) --> TLR9(h) (DNA binding). | CREB1(h) --> CREB1(h) (transactivation) | CREB1(h) --> PTGS2(h) (DNA binding). | CREB1(h) --> STAR(h) (DNA binding; transactivation). | CREB1(h) --> IBSP(h) (DNA binding). | CREB1(h) --> CGA(h) (DNA binding). | CREB1(h) --> Sst(r) (DNA binding). | CREB1(h) --> KCNIP2(ca) (DNA binding). | CREB1(h) --> CD14(h) (transactivation) | CREB1(h) + Mi2-alpha(h) <==> CREB1(h):Mi2-alpha(h) (binding) | CREB1(h) + vimentin(h) <==> CREB1(h):vimentin(h) (binding) | CREB1(h) --> SOD2(h) (DNA binding). | CREB1(h) --> MITF(h) (transactivation) | CREB1(h) --> HMOX1(h) (DNA binding). | CREB1(h) --> MIF(h) (DNA binding). | CREB1(h) --> CHGA(h) (DNA binding). | CREB1(h) --> SLC39A1(h) (transactivation) | CREB1(h) --> B3GAT1(h) (DNA binding). | CREB1(h) --> GH1(h) (DNA binding). | CREB1(h) --> Pck1(r) (DNA binding). | CREB1(h) --> REN(h) (DNA binding). | CREB1(h) --> Hmgcs2(r) (DNA binding). | CREB1(h) --> DIO2(h) (DNA binding). | CREB1(h) --> CCK(h) (DNA binding). | CREB1(h) --> CREB1(h) (expression). |
|---|
Post Translational Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 133 | Phosphoserine. | Swiss-Prot 53.0 | 142 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 133 | Phosphoserine (MAPKAPK2;MAP) | 9829964;7958915;11969286;8887554;15733869;12356771 | Phospho.ELM 6.0 | 111 | Phosphoserine (ATM) | 15073328 | Phospho.ELM 6.0 | 121 | Phosphoserine (ATM;ATR) | 15073328;16293623 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr2 |
Promoter: 208101431 - 208103431 | Agilent_014791 |
chr2 |
Promoter: 208101431 - 208103431 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 208101431 - 208103431 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 208101431 - 208103431 | GSE27584 |
chr2 |
Promoter: 208101431 - 208103431 | GSE27584 |
chr2 |
Promoter: 208101431 - 208103431 | Agilent_014791_44K |