| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 5578 |
Name | PRKCA |
Synonymous | AAG6|PKC-alpha|PKCA|PRKACA;protein kinase C, alpha;PRKCA;protein kinase C, alpha |
Definition | PKC-A|aging-associated gene 6|protein kinase C alpha type |
Position | 17q22-q23.2 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for PRKCA | ||
PCGP somatic mutation [Top] | ||
Variant (Variant; Chr; Position) | Genotype (MutationType; MutationClass; ReferenceAllele; Genotype; Origin) | Disease (CancerType; ValidationStatus; SequencingType) |
|---|---|---|
PRKCA_E17_UTR_3; chr17; 64803889 |
SUB; UTR_3; G; G/A; SOMATIC | HYPO; VALID; WGS |
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.815G>A; p.S272N; |
breast | carcinoma; HER-positive_carcinoma |
c.1922A>G; p.D641G; |
lung | carcinoma; squamous_cell_carcinoma |
c.196C>T; p.Q66*; |
NS | malignant_melanoma |
c.196C>T; p.Q66*; |
NS | malignant_melanoma |
c.1825G>C; p.E609Q; |
oesophagus | carcinoma; adenocarcinoma |
c.1068C>T; p.A356A; |
oesophagus | carcinoma; adenocarcinoma |
c.178T>C; p.F60L; |
oesophagus | carcinoma; adenocarcinoma |
c.173G>T; p.W58L; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.1459G>A; p.E487K; |
pancreas | other; adenoma |
c.1855-6C>T; p.?; |
skin; arm | malignant_melanoma |
c.1567G>T; p.A523S; |
lung | carcinoma; adenocarcinoma |
c.137A>C; p.Q46P; |
lung | carcinoma; adenocarcinoma |
c.1016T>A; p.F339Y; |
ovary | carcinoma |
c.1691A>G; p.E564G; |
pancreas | carcinoma; ductal_carcinoma |
c.540delA; p.N182fs*2; 17:62113701-62113701 |
stomach | carcinoma; adenocarcinoma |
c.1399G>A; p.D467N; 17:62169215-62169215 |
central_nervous_system; brain | glioma |
c.1399G>A; p.D467N; 17:62169215-62169215 |
central_nervous_system; brain | glioma |
c.292C>T; p.P98S; 17:62067938-62067938 |
large_intestine | carcinoma; adenocarcinoma |
c.532C>T; p.R178*; |
breast | carcinoma |
c.1331C>T; p.A444V; |
breast | carcinoma; basal_(triple-negative)_carcinoma |
c.1405G>A; p.V469I; |
prostate | adenoma |
c.1837C>T; p.P613S; 17:62215542-62215542 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.1837C>T; p.P613S; 17:62215542-62215542 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.120C>A; p.I40I; |
lung | carcinoma; adenocarcinoma |
c.1053A>G; p.G351G; |
lung | carcinoma; adenocarcinoma |
c.1576G>A; p.V526I; |
lung | carcinoma; adenocarcinoma |
c.699T>C; p.P233P; |
lung | carcinoma; adenocarcinoma |
c.1779G>A; p.E593E; 17:62215484-62215484 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.1779G>A; p.E593E; 17:62215484-62215484 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV |
c.482G>A; p.R161Q; 17:62072044-62072044 |
ovary | carcinoma; serous_carcinoma |
c.97G>A; p.E33K; |
lung | carcinoma; squamous_cell_carcinoma |
c.1894C>T; p.R632*; |
ovary | carcinoma; serous_carcinoma |
c.1620T>G; p.G540G; |
ovary | carcinoma; serous_carcinoma |
c.32C>T; p.T11M; |
lung | carcinoma; squamous_cell_carcinoma |
c.1796_1797GG>TT; p.R599I; |
lung | carcinoma; adenocarcinoma |
c.1875C>A; p.N625K; |
lung | carcinoma; adenocarcinoma |
c.1404C>G; p.N468K; |
lung | carcinoma; squamous_cell_carcinoma |
c.397G>A; p.D133N; |
lung | carcinoma; squamous_cell_carcinoma |
c.507T>C; p.A169A; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.770G>T; p.G257V; |
lung | carcinoma; adenocarcinoma |
c.1996C>T; p.P666S; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.857A>G; p.Y286C; |
endometrium | carcinoma; endometrioid_carcinoma |
c.645C>T; p.I215I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1515C>T; p.I505I; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.254C>A; p.S85Y; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1779G>A; p.E593E; 17:62215484-62215484 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.294C>T; p.P98P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1741C>T; p.L581L; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1443C>A; p.D481E; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.362T>C; p.L121P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.225C>A; p.H75Q; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1895G>A; p.R632Q; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.346G>A; p.D116N; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.547C>A; p.L183I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1554T>C; p.S518S; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1970C>T; p.S657L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1540delC; p.P514fs*59; |
endometrium | carcinoma; endometrioid_carcinoma |
c.915C>T; p.F305F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1331C>T; p.A444V; |
endometrium | carcinoma; endometrioid_carcinoma |
c.294C>A; p.P98P; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.915C>T; p.F305F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1304T>G; p.F435C; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1508A>G; p.D503G; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1166G>A; p.R389Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1245C>T; p.F415F; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.294C>T; p.P98P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1149C>T; p.C383C; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1164G>A; p.K388K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1854G>A; p.V618V; |
endometrium | carcinoma; endometrioid_carcinoma |
c.280G>A; p.D94N; |
endometrium | carcinoma; endometrioid_carcinoma |
c.513A>C; p.E171D; |
endometrium | carcinoma; endometrioid_carcinoma |
c.293C>T; p.P98L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1756G>C; p.E586Q; |
cervix | carcinoma; squamous_cell_carcinoma |
c.405C>T; p.C135C; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.291delC; p.R99fs*32; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.254C>T; p.S85F; |
skin | malignant_melanoma |
c.880G>A; p.D294N; |
skin | malignant_melanoma |
c.520C>T; p.H174Y; |
skin | malignant_melanoma |
c.558G>A; p.M186I; |
skin | malignant_melanoma |
c.1864G>A; p.G622R; |
skin | malignant_melanoma |
c.540delA; p.N182fs*2; 17:62113701-62113701 |
stomach | adenocarcinoma |
c.810G>A; p.P270P; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; diffuse_large_B_cell_lymphoma |