| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 4040 |
Name | LRP6 |
Synonymous | ADCAD2;low density lipoprotein receptor-related protein 6;LRP6;low density lipoprotein receptor-related protein 6 |
Definition | LRP-6|low-density lipoprotein receptor-related protein 6 |
Position | 12p13.2 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for LRP6 | ||
PCGP somatic mutation [Top] | ||
There is no record for LRP6 | ||
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.1657C>T; p.R553C; |
liver | carcinoma; hepatocellular_carcinoma |
c.1078C>T; p.R360C; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.1078C>T; p.R360C; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma |
c.76G>A; p.A26T; |
lung | carcinoma; squamous_cell_carcinoma |
c.1022G>A; p.R341H; |
lung | carcinoma; squamous_cell_carcinoma |
c.1930C>T; p.R644*; |
lung | carcinoma; squamous_cell_carcinoma |
c.1703T>C; p.I568T; |
ovary | other; neoplasm |
c.2600C>T; p.T867I; |
skin; arm | malignant_melanoma |
c.2601C>T; p.T867T; |
skin; arm | malignant_melanoma |
c.1913G>A; p.R638Q; |
haematopoietic_and_lymphoid_tissue; spleen | lymphoid_neoplasm; marginal_zone_lymphoma |
c.2099T>C; p.V700A; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3058A>G; p.S1020G; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.4505T>G; p.F1502C; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.647+3A>G; p.?; |
liver | carcinoma |
c.2739T>G; p.V913V; |
liver | carcinoma |
c.1646A>G; p.D549G; |
liver | carcinoma |
c.2995G>A; p.G999S; 12:12193354-12193354 |
skin | malignant_melanoma |
c.915T>C; p.F305F; |
oesophagus | carcinoma; adenocarcinoma |
c.938G>T; p.G313V; |
oesophagus; lower_third | carcinoma; adenocarcinoma |
c.2165C>A; p.A722E; |
oesophagus | carcinoma; adenocarcinoma |
c.2164G>A; p.A722T; |
oesophagus | carcinoma; adenocarcinoma |
c.2954G>A; p.R985Q; |
liver | carcinoma |
c.1441C>T; p.R481C; |
liver | carcinoma |
c.4559A>G; p.Y1520C; |
liver | carcinoma; hepatocellular_carcinoma |
c.1255T>C; p.W419R; |
large_intestine; colon | carcinoma |
c.811A>T; p.I271L; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.1024A>G; p.I342V; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.4507G>T; p.G1503*; |
upper_aerodigestive_tract; larynx | carcinoma; squamous_cell_carcinoma |
c.976+2T>C; p.?; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.2947G>A; p.D983N; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.3178C>G; p.R1060G; |
large_intestine; colon | carcinoma |
c.3022C>T; p.P1008S; |
skin; arm | malignant_melanoma |
c.1992T>A; p.A664A; |
skin; leg | malignant_melanoma; nodular |
c.3926G>A; p.G1309E; |
lung | carcinoma; adenocarcinoma |
c.3133G>T; p.G1045W; |
lung | carcinoma; adenocarcinoma |
c.169G>T; p.D57Y; |
lung | carcinoma; adenocarcinoma |
c.287C>G; p.S96C; |
lung | carcinoma; adenocarcinoma |
c.4583C>A; p.P1528H; |
lung | carcinoma; adenocarcinoma |
c.4711C>T; p.P1571S; |
lung | carcinoma; adenocarcinoma |
c.2641G>C; p.V881L; |
central_nervous_system; medulla | primitive_neuroectodermal_tumour-medulloblastoma; classic |
c.844+5G>A; p.?; 12:12231119-12231119 |
skin | malignant_melanoma |
c.2408G>T; p.R803M; |
autonomic_ganglia | neuroblastoma |
c.2993A>G; p.Q998R; 12:12195038-12195038 |
lung | carcinoma; non_small_cell_carcinoma |
c.217G>T; p.E73*; |
bone | osteosarcoma |
c.2515A>G; p.T839A; |
prostate | carcinoma |
c.2539T>C; p.W847R; |
pancreas | carcinoma; ductal_carcinoma |
c.674C>G; p.P225R; 12:12231294-12231294 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.4086G>T; p.P1362P; |
breast | carcinoma; ductal_carcinoma |
c.2418T>G; p.Y806*; |
liver | carcinoma |
c.1802A>G; p.H601R; |
liver | carcinoma |
c.94C>T; p.R32*; |
lung | carcinoma; small_cell_carcinoma |
c.1399G>C; p.E467Q; |
breast | carcinoma; basal_(triple-negative)_carcinoma |
c.1574G>A; p.R525Q; |
breast | carcinoma; basal_(triple-negative)_carcinoma |
c.3524G>A; p.R1175Q; |
prostate | adenoma |
c.3241C>G; p.P1081A; |
prostate | adenoma |
c.2853A>C; p.E951D; |
autonomic_ganglia | neuroblastoma |
c.1023C>T; p.R341R; |
autonomic_ganglia | neuroblastoma |
c.2613C>A; p.G871G; |
ovary | carcinoma; serous_carcinoma |
c.217G>T; p.E73*; |
ovary | carcinoma; serous_carcinoma |
c.4838C>A; p.S1613Y; 12:12165331-12165331 |
ovary | carcinoma; serous_carcinoma |
c.3408G>A; p.R1136R; |
lung | carcinoma; squamous_cell_carcinoma |
c.4360G>A; p.G1454R; |
lung | carcinoma; squamous_cell_carcinoma |
c.2206G>T; p.G736W; |
lung | carcinoma; squamous_cell_carcinoma |
c.949C>T; p.L317L; |
lung | carcinoma; squamous_cell_carcinoma |
c.2570G>A; p.R857H; |
lung | carcinoma; squamous_cell_carcinoma |
c.2826T>C; p.S942S; |
lung | carcinoma; squamous_cell_carcinoma |
c.2570G>T; p.R857L; |
lung | carcinoma; adenocarcinoma |
c.2794C>T; p.P932S; |
lung | carcinoma; squamous_cell_carcinoma |
c.700G>A; p.E234K; |
lung | carcinoma; adenocarcinoma |
c.1114G>A; p.G372S; |
lung | carcinoma; adenocarcinoma |
c.3077G>A; p.R1026H; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.4255G>T; p.A1419S; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.2780G>T; p.R927M; |
lung | carcinoma; squamous_cell_carcinoma |
c.2953C>G; p.R985G; |
ovary | carcinoma; serous_carcinoma |
c.4401A>T; p.G1467G; |
ovary | carcinoma; serous_carcinoma |
c.1904T>G; p.L635W; |
lung | carcinoma; squamous_cell_carcinoma |
c.3668A>G; p.D1223G; |
lung | carcinoma; adenocarcinoma |
c.4557A>G; p.P1519P; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.2058C>T; p.I686I; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.318A>G; p.G106G; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2608C>A; p.Q870K; |
breast | carcinoma |
c.1060C>T; p.L354L; |
breast | carcinoma |
c.3289T>C; p.F1097L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1441C>T; p.R481C; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3891T>C; p.S1297S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1148C>T; p.A383V; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1913G>A; p.R638Q; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.112_113delAA; p.N38fs*23; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2527G>T; p.D843Y; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.291C>T; p.P97P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2024G>A; p.R675Q; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.307G>T; p.D103Y; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.235G>T; p.E79*; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3076C>T; p.R1026C; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2543C>T; p.T848M; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.454A>G; p.M152V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3932C>T; p.A1311V; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.2641G>A; p.V881I; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.229C>T; p.R77*; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.2024G>A; p.R675Q; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.3446G>A; p.G1149E; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.2024G>A; p.R675Q; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.1937C>A; p.S646Y; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.543T>G; p.I181M; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.675A>G; p.P225P; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.260A>T; p.Q87L; |
breast | carcinoma |
c.976G>A; p.G326S; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3428A>C; p.N1143T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1423G>A; p.A475T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.820T>G; p.F274V; |
endometrium | carcinoma; endometrioid_carcinoma |
c.94C>T; p.R32*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1682G>A; p.R561Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2024G>A; p.R675Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3917G>A; p.R1306Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2106C>T; p.F702F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2211G>C; p.Q737H; |
endometrium | carcinoma; endometrioid_carcinoma |
c.4162G>A; p.G1388R; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2568G>A; p.E856E; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1526C>T; p.A509V; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1157G>A; p.R386H; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2178G>A; p.T726T; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1244G>A; p.R415Q; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.4011G>A; p.Q1337Q; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.4837T>C; p.S1613P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3974T>G; p.L1325R; |
endometrium | carcinoma; endometrioid_carcinoma |
c.994C>A; p.L332I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.985G>T; p.E329*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.235G>T; p.E79*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3916C>T; p.R1306*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.4674T>C; p.S1558S; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3811G>C; p.D1271H; |
endometrium | carcinoma; endometrioid_carcinoma |
c.4137C>A; p.G1379G; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3773C>T; p.T1258M; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3849C>A; p.L1283L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1931G>A; p.R644Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.840A>T; p.P280P; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2657G>A; p.R886Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.95G>A; p.R32Q; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1329G>T; p.E443D; |
urinary_tract; bladder | carcinoma |
c.297G>A; p.G99G; |
breast | carcinoma |
c.3712C>A; p.Q1238K; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3260C>T; p.A1087V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2987G>A; p.G996D; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.674C>T; p.P225L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.646C>T; p.R216W; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.109A>G; p.T37A; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.4839C>A; p.S1613S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2996G>T; p.G999V; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1133A>T; p.D378V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.448G>A; p.G150R; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.3550C>T; p.R1184*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3127T>G; p.L1043V; |
endometrium | carcinoma; endometrioid_carcinoma |
c.3076C>T; p.R1026C; |
endometrium | carcinoma; endometrioid_carcinoma |
c.4837T>C; p.S1613P; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.3679A>C; p.R1227R; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1600C>A; p.H534N; |
urinary_tract; bladder | carcinoma |
c.202A>G; p.S68G; |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.3023C>T; p.P1008L; |
prostate | carcinoma; adenocarcinoma |
c.94C>A; p.R32R; |
prostate | carcinoma; adenocarcinoma |
c.4219G>A; p.E1407K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.4838C>A; p.S1613Y; 12:12165331-12165331 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.4838C>A; p.S1613Y; 12:12165331-12165331 |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.2993A>G; p.Q998R; 12:12195038-12195038 |
large_intestine; rectum | carcinoma; adenocarcinoma |
c.3253C>T; p.R1085W; |
breast | carcinoma |
c.17G>A; p.R6K; |
skin | malignant_melanoma |
c.4487C>T; p.S1496L; |
skin | malignant_melanoma |
c.1105C>T; p.P369S; |
skin; face | carcinoma; squamous_cell_carcinoma |
c.2689A>G; p.N897D; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.3551G>T; p.R1184L; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1821T>C; p.P607P; |
stomach | adenocarcinoma |