| General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information | |
|---|---|
Gene ID | 3973 |
Name | LHCGR |
Synonymous | HHG|LCGR|LGR2|LH/CG-R|LH/CGR|LHR|LHRHR|LSH-R|ULG5;luteinizing hormone/choriogonadotropin receptor;LHCGR;luteinizing hormone/choriogonadotropin receptor |
Definition | hypergonadotropic hypogonadism|lutropin-choriogonadotropic hormone receptor|lutropin/choriogonadotropin receptor |
Position | 2p21 |
Gene Type | protein-coding |
Gene Mutation: | PCGP germline mutation PCGP somatic mutation COSMIC somatic mutation |
PCGP germline mutation [Top] | ||
There is no record for LHCGR | ||
PCGP somatic mutation [Top] | ||
Variant (Variant; Chr; Position) | Genotype (MutationType; MutationClass; ReferenceAllele; Genotype; Origin) | Disease (CancerType; ValidationStatus; SequencingType) |
|---|---|---|
LHCGR_L480S; chr2; 48915497 |
SUB; MISSENSE; A; A/G; SOMATIC | MB; VALID; WGS |
COSMIC somatic mutation [Top] | ||
Mutation (CDS; AA; Chr) | Site | Histology |
|---|---|---|
c.1660C>T; p.R554*; |
lung | carcinoma; undifferentiated_carcinoma |
c.1718T>A; p.I573N; |
breast | carcinoma; HER-positive_carcinoma |
c.1847C>T; p.S616F; |
NS | malignant_melanoma |
c.1847C>T; p.S616F; |
NS | malignant_melanoma |
c.76C>T; p.R26C; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.2050C>A; p.H684N; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1345G>A; p.A449T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.83C>T; p.A28V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1100G>C; p.W367S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.815C>T; p.T272M; |
pancreas | carcinoma |
c.1747G>A; p.A583T; |
pancreas | carcinoma |
c.1949T>A; p.L650H; |
lung | carcinoma; squamous_cell_carcinoma |
c.1400C>T; p.T467I; |
skin; shoulder | malignant_melanoma |
c.1345G>A; p.A449T; |
stomach | carcinoma; intestinal_adenocarcinoma |
c.227T>C; p.I76T; |
stomach | carcinoma; intestinal_adenocarcinoma |
c.675A>C; p.K225N; |
oesophagus | carcinoma; adenocarcinoma |
c.1991A>C; p.K664T; |
oesophagus | carcinoma; adenocarcinoma |
c.1815A>C; p.K605N; |
oesophagus | carcinoma; adenocarcinoma |
c.1009T>C; p.L337L; |
oesophagus; lower_third | carcinoma; adenocarcinoma |
c.2082T>G; p.T694T; |
oesophagus | carcinoma; adenocarcinoma |
c.1162C>A; p.R388S; |
oesophagus | carcinoma; adenocarcinoma |
c.1436G>A; p.R479Q; |
oesophagus; lower_third | carcinoma; adenocarcinoma |
c.1690G>A; p.D564N; 2:48768750-48768750 |
breast | carcinoma; ductal_carcinoma |
c.1524C>T; p.Y508Y; |
liver | carcinoma |
c.967G>A; p.E323K; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.656G>A; p.R219H; |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma |
c.815C>T; p.T272M; |
pancreas | carcinoma; ductal_carcinoma |
c.1747G>A; p.A583T; |
pancreas | carcinoma; ductal_carcinoma |
c.1612G>A; p.A538T; |
ovary | carcinoma |
c.1183C>T; p.R395C; |
skin; trunk | malignant_melanoma; nodular |
c.1151T>C; p.L384P; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; hairy_cell_leukaemia |
c.1523A>T; p.Y508F; |
lung | carcinoma; adenocarcinoma |
c.178C>A; p.P60T; |
lung | carcinoma; adenocarcinoma |
c.682G>C; p.D228H; |
lung | carcinoma; adenocarcinoma |
c.2065G>T; p.A689S; |
lung | carcinoma; adenocarcinoma |
c.1390A>G; p.R464G; |
lung | carcinoma; adenocarcinoma |
c.460G>A; p.E154K; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; hairy_cell_leukaemia |
c.460G>A; p.E154K; |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; hairy_cell_leukaemia |
c.460G>A; p.E154K; |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; myelodysplastic_syndrome |
c.1513G>A; p.V505I; |
liver | carcinoma; hepatocellular_carcinoma |
c.1023C>T; p.P341P; |
breast | carcinoma |
c.1790C>A; p.P597H; |
breast | carcinoma; lobular_carcinoma |
c.1388A>G; p.E463G; |
breast | carcinoma; ductal_carcinoma |
c.1160G>T; p.S387I; |
NS | NS |
c.771A>C; p.K257N; |
bone | chondrosarcoma |
c.1698G>A; p.K566K; |
liver | carcinoma |
c.1813A>G; p.K605E; |
lung | carcinoma; small_cell_carcinoma |
c.490A>G; p.I164V; |
lung | carcinoma; small_cell_carcinoma |
c.167T>C; p.L56P; |
breast | carcinoma; basal_(triple-negative)_carcinoma |
c.1300C>A; p.Q434K; |
large_intestine; caecum | adenoma |
c.1439T>C; p.L480S; |
central_nervous_system; brain | primitive_neuroectodermal_tumour-medulloblastoma |
c.665C>T; p.T222I; |
endometrium | carcinoma; serous_carcinoma |
c.496G>A; p.G166R; |
lung | carcinoma; adenocarcinoma |
c.836G>T; p.C279F; |
lung | carcinoma; adenocarcinoma |
c.1745T>C; p.M582T; 2:48768695-48768695 |
ovary | carcinoma; serous_carcinoma |
c.607G>A; p.E203K; |
lung | carcinoma; squamous_cell_carcinoma |
c.1822C>T; p.L608L; |
lung | carcinoma; squamous_cell_carcinoma |
c.816G>T; p.T272T; |
lung | carcinoma; squamous_cell_carcinoma |
c.1929C>A; p.C643*; |
lung | carcinoma; squamous_cell_carcinoma |
c.1337C>A; p.T446N; |
lung | carcinoma; squamous_cell_carcinoma |
c.732C>A; p.S244S; |
lung | carcinoma; squamous_cell_carcinoma |
c.1213G>A; p.D405N; |
ovary | carcinoma; serous_carcinoma |
c.1583T>C; p.I528T; 2:48768857-48768857 |
ovary | carcinoma; serous_carcinoma |
c.1845T>A; p.N615K; |
ovary | carcinoma; serous_carcinoma |
c.1562C>A; p.T521N; |
lung | carcinoma; squamous_cell_carcinoma |
c.1041A>G; p.P347P; |
lung | carcinoma; adenocarcinoma |
c.1660C>T; p.R554*; |
lung | carcinoma; adenocarcinoma |
c.1484C>T; p.S495F; |
lung | carcinoma; squamous_cell_carcinoma |
c.583A>C; p.N195H; |
lung | carcinoma; adenocarcinoma |
c.1150C>A; p.L384I; |
lung | carcinoma; squamous_cell_carcinoma |
c.1930T>G; p.C644G; |
lung | carcinoma; squamous_cell_carcinoma |
c.454A>G; p.I152V; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.1988G>C; p.C663S; |
lung | carcinoma; squamous_cell_carcinoma |
c.1482T>C; p.S494S; |
lung | carcinoma; squamous_cell_carcinoma |
c.1016A>T; p.K339M; |
lung | carcinoma; squamous_cell_carcinoma |
c.737A>C; p.Q246P; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.1517G>T; p.S506I; |
lung; right_upper_lobe | carcinoma; adenocarcinoma |
c.1906C>A; p.L636I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1612G>T; p.A538S; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1764_1765insT; p.A589fs*17; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.186A>C; p.K62N; |
breast | carcinoma |
c.1690G>T; p.D564Y; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.950A>G; p.Y317C; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1481C>T; p.S494F; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.453C>T; p.F151F; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.656G>A; p.R219H; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1646T>G; p.I549S; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.621C>T; p.N207N; |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia |
c.1691A>G; p.D564G; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1922T>G; p.F641C; |
endometrium | carcinoma; endometrioid_carcinoma |
c.712C>T; p.P238S; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1030G>C; p.A344P; |
breast | carcinoma |
c.1725C>A; p.I575I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1864C>A; p.L622M; |
endometrium | carcinoma; endometrioid_carcinoma |
c.731C>T; p.S244F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.611T>G; p.L204R; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1980C>T; p.T660T; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.457C>T; p.L153L; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1902C>A; p.F634L; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.774delA; p.K258fs*16; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1746G>A; p.M582I; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1890C>T; p.F630F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.946C>A; p.L316I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.370C>T; p.R124*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1484C>T; p.S495F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.855G>A; p.L285L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1583T>C; p.I528T; 2:48768857-48768857 |
endometrium | carcinoma; endometrioid_carcinoma |
c.752C>A; p.T251K; |
endometrium | carcinoma; endometrioid_carcinoma |
c.457C>T; p.L153L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1436G>T; p.R479L; |
endometrium | carcinoma; endometrioid_carcinoma |
c.94G>A; p.E32K; |
breast | carcinoma |
c.426G>A; p.T142T; |
cervix | carcinoma; squamous_cell_carcinoma |
c.390C>A; p.I130I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1150C>A; p.L384I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1027T>A; p.C343S; |
breast | carcinoma |
c.1746G>A; p.M582I; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.929A>C; p.K310T; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1745T>C; p.M582T; 2:48768695-48768695 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1281T>A; p.Y427*; |
prostate | carcinoma; adenocarcinoma |
c.1744A>G; p.M582V; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1582A>T; p.I528L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.158G>A; p.R53Q; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1746G>A; p.M582I; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1018A>G; p.T340A; |
kidney | carcinoma; clear_cell_renal_cell_carcinoma |
c.1660C>T; p.R554*; |
endometrium | carcinoma; endometrioid_carcinoma |
c.2021C>T; p.S674F; |
endometrium | carcinoma; endometrioid_carcinoma |
c.591G>A; p.T197T; |
endometrium | carcinoma; endometrioid_carcinoma |
c.425C>T; p.T142M; |
endometrium | carcinoma; endometrioid_carcinoma |
c.364C>A; p.L122I; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1584A>G; p.I528M; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1764_1765insT; p.A589fs*17; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1690G>A; p.D564N; 2:48768750-48768750 |
large_intestine; colon | carcinoma; adenocarcinoma |
c.669G>T; p.G223G; |
breast | carcinoma |
c.715A>G; p.S239G; |
endometrium | carcinoma; endometrioid_carcinoma |
c.1584A>T; p.I528I; |
large_intestine; caecum | carcinoma; adenocarcinoma |
c.1691A>G; p.D564G; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.994G>C; p.E332Q; |
breast | carcinoma |
c.1764delT; p.F588fs*14; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.464T>G; p.I155S; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.813C>T; p.A271A; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1691A>G; p.D564G; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1584A>C; p.I528I; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.1582A>T; p.I528L; |
large_intestine; colon | carcinoma; adenocarcinoma |
c.733A>G; p.I245V; |
urinary_tract; bladder | carcinoma |
c.263G>A; p.R88K; |
skin | malignant_melanoma |
c.2015A>C; p.K672T; |
skin | malignant_melanoma |
c.235G>A; p.E79K; |
skin | malignant_melanoma |
c.1730C>T; p.T577I; |
skin | malignant_melanoma |
c.512G>A; p.G171E; |
skin | malignant_melanoma |
c.736C>T; p.Q246*; |
skin; neck | malignant_melanoma |
c.235G>A; p.E79K; |
skin | malignant_melanoma |
c.187G>A; p.V63M; |
skin; mucosal | malignant_melanoma |
c.1847C>T; p.S616F; |
skin; scalp | carcinoma; squamous_cell_carcinoma |
c.616G>A; p.E206K; |
skin; scalp | carcinoma; squamous_cell_carcinoma |