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Pediatric cancer database
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

161742

Name

SPRED1

Synonymous

NFLS;sprouty-related, EVH1 domain containing 1;SPRED1;sprouty-related, EVH1 domain containing 1

Definition

EVH1/Sprouty domain containing protein|hSpred1|spred-1|sprouty-related, EVH1 domain-containing protein 1|suppressor of Ras/MAPK activation

Position

15q14

Gene Type

protein-coding

Gene Mutation:

PCGP germline mutation
PCGP somatic mutation
COSMIC somatic mutation

PCGP germline mutation   [Top]

Variant (Variant; Chr; Position)

Genotype (MutationType; MutationClass; ReferenceAllele; Genotype; Origin)

Disease (CancerType; ValidationStatus; SequencingType)

SPRED1_Q104*; chr15; 38614544

 SUB; NONSENSE; C; C/T; GERMLINEHYPO; PUTATIVE-HQ;

SPRED1_Q104*; chr15; 38614544

 SUB; NONSENSE; C; C/T; GERMLINEHYPO; PUTATIVE-HQ; EXOME

PCGP somatic mutation   [Top]

Variant (Variant; Chr; Position)

Genotype (MutationType; MutationClass; ReferenceAllele; Genotype; Origin)

Disease (CancerType; ValidationStatus; SequencingType)

SPRED1_Q104*; chr15; 38614544

 SUB; NONSENSE; C; C/T; SOMATICHYPO; VALID;

SPRED1_Q104*; chr15; 38614544

 SUB; NONSENSE; C; C/T; SOMATICHYPO; VALID; EXOME

SPRED1_E7_UTR_3; chr15; 38643896

 SUB; UTR_3; C; C/T; SOMATICMB; VALID; WGS

SPRED1_Y420*; chr15; 38643790

 SUB; NONSENSE; C; C/A; SOMATICRHB; PUTATIVE-HQ; EXOME

COSMIC somatic mutation   [Top]

Mutation (CDS; AA; Chr)

Site

Histology

c.878T>A; p.L293Q;

livercarcinoma; hepatocellular_carcinoma

c.686T>C; p.V229A;

large_intestine; coloncarcinoma; adenocarcinoma

c.863A>C; p.K288T;

large_intestine; coloncarcinoma; adenocarcinoma

c.818G>T; p.R273I;

lungcarcinoma; adenocarcinoma

c.982G>T; p.E328*;

lungcarcinoma; adenocarcinoma

c.148C>T; p.Q50*;

skin; handmalignant_melanoma

c.959_966delTTAAGAAG; p.K322fs*7;

oesophagus; lower_thirdcarcinoma; adenocarcinoma

c.80C>G; p.S27*;

upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinoma

c.473A>C; p.Q158P;

lungcarcinoma; adenocarcinoma

c.1122C>T; p.S374S;

lungcarcinoma; adenocarcinoma

c.1304G>T; p.C435F;

lungcarcinoma; adenocarcinoma

c.303_304insA; p.T102fs*7;

skin; facemalignant_melanoma

c.124G>A; p.V42I;

haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myeloma

c.821A>C; p.D274A; 15:36430643-36430643

 ovarycarcinoma; serous_carcinoma

c.738C>G; p.V246V; 15:36430560-36430560

 ovarycarcinoma; serous_carcinoma

c.322G>A; p.D108N;

lungcarcinoma; squamous_cell_carcinoma

c.71G>C; p.R24P;

lungcarcinoma; squamous_cell_carcinoma

c.47G>T; p.R16L;

lungcarcinoma; adenocarcinoma

c.550A>G; p.R184G;

lung; left_upper_lobecarcinoma; adenocarcinoma

c.1053A>C; p.K351N;

lung; right_upper_lobecarcinoma; adenocarcinoma

c.151G>T; p.E51*;

lungcarcinoma; squamous_cell_carcinoma

c.1188C>T; p.S396S;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.966G>A; p.K322K;

large_intestine; coloncarcinoma; adenocarcinoma

c.1121G>T; p.S374I;

large_intestine; coloncarcinoma; adenocarcinoma

c.161G>A; p.G54D;

large_intestine; coloncarcinoma; adenocarcinoma

c.350G>A; p.R117Q;

large_intestine; coloncarcinoma; adenocarcinoma

c.110G>A; p.S37N;

large_intestine; coloncarcinoma; adenocarcinoma

c.430G>T; p.E144*;

large_intestine; coloncarcinoma; adenocarcinoma

c.591T>C; p.F197F;

large_intestine; rectumcarcinoma; adenocarcinoma

c.71G>A; p.R24Q;

large_intestine; rectumcarcinoma; adenocarcinoma

c.71G>A; p.R24Q;

endometriumcarcinoma; endometrioid_carcinoma

c.781T>C; p.Y261H;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.395A>G; p.N132S;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.201C>G; p.D67E;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.440C>A; p.S147Y;

endometriumcarcinoma; endometrioid_carcinoma

c.1283G>A; p.R428H;

endometriumcarcinoma; endometrioid_carcinoma

c.337G>A; p.D113N;

breastcarcinoma

c.582+1G>T; p.?;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.123C>T; p.S41S;

kidneycarcinoma; clear_cell_renal_cell_carcinoma

c.182G>A; p.R61H;

breastcarcinoma

c.279G>C; p.K93N;

breastcarcinoma

c.53G>A; p.R18Q;

large_intestine; coloncarcinoma; adenocarcinoma

c.185G>A; p.G62E;

urinary_tract; bladdercarcinoma

c.1188_1190delCGA; p.D398delD;

large_intestine; coloncarcinoma; adenocarcinoma

c.821A>G; p.D274G;

large_intestine; coloncarcinoma; adenocarcinoma

c.1117G>A; p.E373K;

urinary_tract; bladdercarcinoma

c.633C>T; p.Y211Y;

prostatecarcinoma

c.1093C>T; p.Q365*;

skinmalignant_melanoma

c.1057C>T; p.Q353*;

skinmalignant_melanoma

c.613C>T; p.Q205*;

skinmalignant_melanoma

c.766C>T; p.R256C;

stomachadenocarcinoma

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