| General information | Literature | Expression | Regulation | Mutation | Homolog | Interaction |
Basic Information | |
|---|---|
Gene ID | 5604 |
Name | MAP2K1 |
Synonymous | mitogen-activated protein kinase kinase 1;MAP2K1;mitogen-activated protein kinase kinase 1 |
Definition | ERK activator kinase 1|MAPK/ERK kinase 1|MAPKK 1|MEK 1|dual specificity mitogen-activated protein kinase kinase 1|protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) |
Position | 15q22.1-q22.33 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors [Top] |
Regulation From TransFac database | MEK1(h) + ATP --H-Ras(h):GTP:NO:Raf-1(h)--> MEK1(h){p} + ADP (phosphorylation) | Raf-1(h) + MEK1(h) <==> Raf-1(h):MEK1(h) (binding) | MEK1(h) + ATP --> MEK1(h){p} + ADP (phosphorylation) | MEK1(h) + ATP --Lck(m.s.)--> MEK1(h){pY} + ADP (phosphorylation) | MEK1(h) + Raf-1(h) <==> MEK1(h):Raf-1(h) (binding) | Grb10zeta(h) + MEK1(h) <==> Grb10zeta(h):MEK1(h) (binding) | MEK1(h) --> E47(h){p} (increase of phosphorylation) | MEK1(h) --> E47(m){p} (increase of phosphorylation) | MEK1(h) --/ E47(h) (decrease of abundance) | MEK1(h) --> E47(h){p}:Skp2(h) (increase of binding) | MEK1(h) --> BIRC3(h) (transactivation) | MEK1(h) --> MICA(h) (increase of abundance) | MEK1(h) + PPARgamma(h) <==> MEK1(h):PPARgamma(h) (binding) | MEK1(h) + ATP --> MEK1(h){pS} + ADP (phosphorylation) | MEK1(h) --/ NOTCH1(h) (transrepression) | MAP2K1(h) --> MEK1(h) (expression). | CSE1(h) + ATP --MEK1(h)--> CSE1(h){pY} + ADP (phosphorylation) | ERK1(m) + ATP --MEK1(h)--> ERK1(m){p} + ADP (phosphorylation) | ERK2(m) + ATP --MEK1(h)--> ERK2(m){p} + ADP (phosphorylation) | ERK1(h) + ATP --MEK1(h)--> ERK1(h){p} + ADP (phosphorylation) | ERK2(h) + ATP --MEK1(h)--> ERK2(h){p} + ADP (phosphorylation) | MEK1(h) + 2 ATP --> MEK1(h){pS218}{pS222} + 2 ADP (phosphorylation) | MEK1(h) + ATP --Cot(h){p}--> MEK1(h){p} + ADP (phosphorylation) | MEK1(h) + PPARgamma1(m.s.) <==> MEK1(h):PPARgamma1(m.s.) (binding) | MEK1(h) + PPARgamma1(h) <==> MEK1(h):PPARgamma1(h) (binding) | MEK1(h) + PPARgamma(m.s.) <==> MEK1(h):PPARgamma(m.s.) (binding) | MEK1(h) + ATP --Cdk5(h)--> MEK1(h){p} + ADP (phosphorylation) | ERK2(r) + MEK1(h) <==> ERK2(r):MEK1(h) (binding) | ERK1(h) + MEK1(h) <==> ERK1(h):MEK1(h) (binding) | ERK2(r) + MEK1(h) <==> ERK2(r):MEK1(h) (binding) | MAP2K1(h) --> MEK1(h) (expression). | HCV-NS5A(HCV) + ATP --MEK1(h)--> HCV-NS5A(HCV){p} + ADP (phosphorylation) | ERK2(r) + ATP --MEK1(h)--> ERK2(r){p} + ADP (phosphorylation) |
|---|
Post Transcriptional Modification [Top] | |||
Location (AA) | PTM type | Literature | Database | 218 | Phosphoserine (by RAF). | Swiss-Prot 53.0 | 222 | Phosphoserine (by RAF). | Swiss-Prot 53.0 | 221 | Phosphoserine (MAP3K8;MAP3K) | 94178255;15175348;7624324;8039496;15466476;8131746 | Phospho.ELM 6.0 | 217 | Phosphoserine (MAP3K8;MAP2K) | 94178255;7873542;7936666;7624324;15466476;8131746 | Phospho.ELM 6.0 | 385 | Phosphothreonine (MAPK1) | 10567369 | Phospho.ELM 6.0 | 211 | Phosphoserine | 12506122 | Phospho.ELM 6.0 | 291 | Phosphothreonine (MAPK1) | 10567369;9351825 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
Chromosome | Location | Source |
|---|---|---|
chr15 |
Promoter: 64465179 - 64467179 | Agilent_014791 |
chr15 |
Promoter: 64465179 - 64467179 | GSE27584 |
chr15 |
Promoter: 64465179 - 64467179 | Agilent_014791_44K |